Implementing epilepsy guidelines within a learning disability service

SummaryPurposeTo investigate the usefulness of the implementation of NICE guidelines when reviewing care within an outpatient learning disability service.MethodsWe set up a multi disciplinary specialist epilepsy clinic and reviewed all patients with a diagnosis of epilepsy using a specific assessment document based on NICE guidance. We then audited clinical documentation prior to and after the implementation of the clinic.ResultsWe reviewed 23 patients and found that implementing NICE guidelines showed improvements to individuals’ seizure assessments and epilepsy management. When comparing specific areas related to NICE implementation we found that 83% compared to 6% of patients had accurate name and detailed seizure descriptions. We made changes to seizure diagnosis in 76% of patients and improved the level of recording of seizure frequency and severity. Finally 91% compared to 50% of consultations led to changes in treatment plans.ConclusionWe found that implementing the NICE guidelines allowed us to use a systematic approach to epilepsy management, which in turn led to identifiable improvement in documentation and patient care

Putting Theory into Practice: Market Failure and Market Based Instruments (MBIs)

The use of market-based instruments (MBIs) to provide and protect ecosystem services has gained significant attention in Australia. Despite their popularity, MBIs are not appropriate for the provision of all ecosystem services. Rather, MBIs must be carefully designed given the ecosystem service outcomes desired, while meeting the needs of participants. In this paper we detail the importance of a robust theoretical structure to underpin the selection and design of an MBI. In particular, we demonstrate the role of identifying and analysing the nature of the market failures present, and their implications for instrument design. Our conclusions are illustrated using several regional MBI case studies.Market Based Instruments (MBIs), ecosystem services, conservation

Two practical Java software tools for small-angle X-ray scattering analysis of biomolecules

Small-angle X-ray scattering has established itself as a common technique in structural biology research. Here, two novel Java applications to aid modelling of three-dimensional macromolecular structures based on small-angle scattering data are described. MolScat is an application that computes small-angle scattering intensities from user-provided three-dimensional models. The program can fit the theoretical scattering intensities to experimental X-ray scattering data. SAFIR is a program for interactive rigid-body modelling into low-resolution shapes restored from small-angle scattering data. The program has been designed with an emphasis on ease of use and intuitive handling. An embedded version of MolScat is used to enable quick evaluation of the fit between the model and experimental scattering data. SAFIR also provides options to refine macromolecular complexes with optional user-specified restraints against scattering data by means of a Monte Carlo approach

Decentralized planning for autonomous agents cooperating in complex missions

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 121-125).Planning for autonomous vehicles remains an important and challenging research topic. This thesis focuses on decentralized planning for autonomous agents performing complex missions. These types of missions often involve a set of tasks, each representing a component of the mission. Task planning algorithms may be used as part of the mission planner to assign agents to tasks; however, the decentralized task assignment problem becomes increasingly difficult when there exists coupling in the task set. Coupling may be in the form of assignment relationships, where the value of a task is condition on whether or not another task has been assigned, or temporal relationships where the value of a task is conditioned on when it is performed relative to other tasks. In this work, task coupling is treated as a constraint, and a task planning framework is introduced which is specifically designed to ensure that all coupled constraints are satisfied by the assignment. The new algorithm is developed from a baseline Consensus-Based Bundle Algorithm (CBBA) and is called Coupled- Constraint CBBA, or CCBBA. The new algorithm is compared to the baseline in a complex mission simulation and is found to outperform the baseline by up to a factor of 3 with respect to assignment score. A separate extension to CBBA is also developed for satisfying refuel constraints in the task assignment process, and the technique is verified through numerical simulation. Lastly, this thesis examines the autonomous search problem where a fleet of sensor-equipped agents are deployed to find objects of interest in an environment. A local search strategy developed for the Onboard Planning System for UAVs in Support of Expeditionary Reconnaissance and Surveillance (OPS-USERS) program is described, which is a receding horizon optimization technique. A global search strategy is also described which extends the planning horizon of the local search strategy by incorporating larger amounts of information into the planning. The two strategies are compared both with and without an artificially simulated human operator, and the global search strategy is shown to outperform the local search strategy in terms of number of targets found.by Andrew Whitten.S.M

Experiments with regulations & markets linking upstream tree plantations with downstream water users

Land-use change in upper catchments impact downstream water flows. As trees use large amounts of water the expansion of upstream plantations can substantially reduce water availability to downstream users. There can also be impacts on downstream salinity due to reduced dilution flows. In some jurisdictions afforestation requires the purchase of water rights from downstream holders, while in others it does not, effectively handing the water rights to the upstream landholders. We consider the economic efficiency and equity (profitability and distributional) consequences of upstream land use change in the presence of a water market under alternate property rights regimes and different salinity scenarios.experimental-economics, tree-plantations, environmental-services, urban, irrigation, stock & domestic, water use, land use,

Decentralized Task Allocation with Coupled Constraints in Complex Missions

This paper presents a decentralized algorithm that creates feasible assignments for a network of autonomous agents in the presence of coupled constraints. The coupled constraints address complex mission characteristics that include assignment relationships, where the value of a task is conditioned on whether or not another task has been assigned, and temporal relationships, where the value of a task is conditioned on when it is performed relative to other tasks. The new algorithm is developed as an extension to the Consensus-Based Bundle Algorithm (CBBA), introducing the notion of pessimistic or optimistic bidding strategies and the relative timing constraints between tasks. This extension, called Coupled-Constraint CBBA (CCBBA), is compared to the baseline in a complex mission simulation and is found to outperform the baseline, particularly for task-rich scenarios.United States. Air Force Office of Scientific Research (Grant FA9550-08-1-0086)United States. Air Force Office of Scientific Research. Multidisciplinary University Research Initiative (Grant FA9550-08-1-0356

De‐municipalisation? Legacies of austerity for England's urban parks

Parks are important urban infrastructures that contribute a broad range of health, environmental, social, and economic benefits. Despite this, UK parks' status as non‐statutory services makes them particularly vulnerable to local authority budget cuts. This paper focuses on parks in English cities as these were particularly affected by severe cuts to local government budgets 2010–2019. This period of austerity affected parks provision in various ways, including service reductions, increased reliance on volunteer labour, and pressure to generate commercial revenue. Combined with a series of other factors, including ongoing neoliberalisation, austerity‐driven changes left a range of physical, social, and institutional legacies. This paper explores these using the notion of de‐municipalisation to frame the discussion. The paper is based on an innovative synthesis of research conducted by the authors 2016–2022 and presented at the RGS‐IBG Annual Conference in 2021. The paper identifies that austerity‐driven changes included an experimental ‘shaking up’ of park governance, away from local authorities and with greater involvement from national‐level NGOs. Changes also involved a ‘breaking down’ of municipal management, with responsibility delegated to dedicated parks trusts but also to community groups and volunteers. Ultimately, austerity 2010–2019 altered parks governance, transforming the stewardship and condition of parks, reducing accountability and accessibility, and exacerbating inequities in parks provision. Rather than representing new directions, these changes perpetuate those instigated in previous austerity eras. The noted trend towards de‐municipalisation also reduces parks' capacity to serve as integrated infrastructures – something that may hinder efforts to make cities more sustainable and resilient

Charge density analysis of two polymorphs of antimony(III) oxide

High-resolution X-ray diffraction data have been collected on the cubic polymorph of antimony(III) oxide (senarmontite) to determine the charge distribution in the crystal. The results are in quantitative agreement with crystal Hartree–Fock calculations for this polymorph, and have been compared with theoretical calculations on the orthorhombic polymorph (valentinite). Information about the nature of bonding and relative bond strengths in the two polymorphs has been extracted in a straightforward manner via topological analysis of the electron density. All the close contacts in both polymorphs are found to be similar in nature based on the value of the Laplacian, the magnitude of the electron density and the local energy density at the bond critical points, and these characterise the observed interactions as substantially polar covalent, similar to molecular calculation results on Si–O and Ge–O. Electrostatic potential isosurfaces reveal the octopolar nature of this function for senarmontite, and shed light on the observed packing arrangement of Sb4O6 molecules in the crystal

Dimensions and Global Twist of Single-Layer DNA Origami Measured by Small-Angle X-ray Scattering

The rational design of complementary DNA sequences can be used to create nanostructures that self-assemble with nanometer precision. DNA nanostructures have been imaged by atomic force microscopy and electron microscopy. Small-angle X-ray scattering (SAXS) provides complementary structural information on the ensemble-averaged state of DNA nanostructures in solution. Here we demonstrate that SAXS can distinguish between different single-layer DNA origami tiles that look identical when immobilized on a mica surface and imaged with atomic force microscopy. We use SAXS to quantify the magnitude of global twist of DNA origami tiles with different crossover periodicities: these measurements highlight the extreme structural sensitivity of single-layer origami to the location of strand crossovers. We also use SAXS to quantify the distance between pairs of gold nanoparticles tethered to specific locations on a DNA origami tile and use this method to measure the overall dimensions and geometry of the DNA nanostructure in solution. Finally, we use indirect Fourier methods, which have long been used for the interpretation of SAXS data from biomolecules, to measure the distance between DNA helix pairs in a DNA origami nanotube. Together, these results provide important methodological advances in the use of SAXS to analyze DNA nanostructures in solution and insights into the structures of single-layer DNA origami