560 research outputs found
X marks the spot: catheter aspiration using the Inari FlowTriever device to debulk defibrillator lead vegetations prior to transvenous lead extractionâa case report
Background: When cardiac implantable electronic device infection occurs, standard therapy is usually total system extraction. Transvenous lead extraction is preferable to open heart surgical extraction, unless contraindicated because of the presence of very large vegetations on the intravenous leads according to the European Society of Cardiology guidelines. Extraction of transvenous leads with vegetations risks distal embolism resulting in obstruction and/or infection in the pulmonary arteries. Catheter aspiration of vegetations or thrombi has been performed prior to transvenous lead extraction using a partial veno-venous extracorporeal bypass circuit. We report the use of a single-access aspiration system using the Inari FlowTriever 24 French system to debulk a defibrillator lead before percutaneous extraction. Case summary: A 79-year-old male presented with fever 18 years after his first implantable cardioverter defibrillator implant and 9 years after his most recent pulse generator change. Two large vegetations were identified on his transvenous defibrillator lead on the atrial aspect, near the tricuspid annulus, which were aspirated using the Inari Medical 24Fr FlowTriever aspiration catheter. We describe anatomical considerations during the approach and a technique to localize the vegetations based on a combination of fluoroscopy and transoesophageal echocardiogram guidance. Discussion: This case demonstrates the safe and effective use of the Inari Medical 24Fr FlowTriever aspiration catheter in debulking a defibrillator lead before transvenous lead extraction. This method uses a single venous puncture and is not dependent on extracorporeal bypass. Apart from reducing complexity, this technique may be advantageous in patients where anticoagulation needs to be minimised
The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database
Background
Percutaneous coronary intervention (PCI) is increasingly utilized for treatment of coronary disease involving the unprotected left main stem (ULMS). However, no studies to date have examined the outcomes of such interventions when complicated by coronary perforation (CP).
Methods
Using the British Cardiovascular Intervention society (BCIS) database, data were analyzed on all ULMSâPCI procedures complicated by CP in England and Wales between 2007 and 2014. Multivariate logistic regressions were used to identify predictors of ULMS CP and to evaluate the association between this complication and outcomes.
Results
During 10,373 ULMSâPCI procedures, CP occurred more frequently than in nonâULMSâPCI (0.9 vs. 0.4%, pâ<â.001) with a stable annual incidence. Covariates associated with CP included number of stents used, female gender, use of rotational atherectomy and chronic total occlusion (CTO) intervention. Adjusted odds of adverse outcomes for ULMSâPCI complicated by CP were higher for periâprocedural complications including cardiogenic shock, tamponade, sideâbranch loss, DC cardioversion, inâhospital major bleeding, transfusion requirement, and periâprocedural myocardial infarction. There were also significantly increased odds for inâhospital major adverse cardiac events (MACCE, OR 8.961, 95% CI [4.902â16.383]) and 30âday mortality (OR 5.301, 95% CI [2.741â10.251]).
Conclusions
CP is an infrequent event during ULMSâPCI and is predicted by female gender, rotational atherectomy, CTO interventions or number of stents used. CP was associated with significantly higher odds of mortality and morbidity, but at rates similar to previously published allâcomer PCI complicated by CP
Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT PE)
BACKGROUND
Prior clinical trials have demonstrated the efficacy of ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk pulmonary embolism (PE) using reduced thrombolytic doses and shorter infusion durations. However, utilization and safety of such strategies in broader PE populations remain unclear. The KNOCOUT PE (The EKoSoNic Registry of the Treatment and Clinical Outcomes of Patients With Pulmonary Embolism) registry is a multicenter international registry designed to study the treatment of acute PE with USCDT, with focus on safety outcomes.
METHODS
The KNOCOUT PE prospective cohort included 489 patients (64 sites internationally) with acute intermediate-high or high-risk PE treated with USCDT between March 2018 and June 2020. Principal safety outcomes were independently adjudicated International Society on Thrombosis and Haemostasis major bleeding at 72 hours post-treatment and mortality within 12 months of treatment. Additional outcomes included change in right ventricular/left ventricular ratio and quality of life measures over 12 months.
RESULTS
Mean alteplase (r-tPA [recombinant tissue-type plasminogen activator]) infusion duration was 10.5 hours. Mean total r-tPA dose was 18.1 mg, with 31.0% of patients receiving â€12 mg. Major bleeding events within 72 hours occurred in 1.6% (8/489) of patients. One patient experienced worsening of a preexisting subdural hematoma after USCDT and therapeutic anticoagulation, which ultimately required surgery. All-cause mortality at 30 days was 1.0% (5/489). Improvement in PE quality of life score was observed with a 41.1% (243/489, 49.7%) and 44.2% (153/489, 31.3%) mean relative reduction by 3 and 12 months, respectively.
CONCLUSIONS
In a prospective observational cohort study of patients with intermediate-high and high-risk PE undergoing USCDT, mean r-tPA dose was 18 mg, and the rates of major bleeding and mortality were low.
REGISTRATION
URL: https://www.clinicaltrials.gov; Unique identifier: NCT03426124
Thermal stress induces glycolytic beige fat formation via a myogenic state.
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of ÎČ-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival
GAMA: towards a physical understanding of galaxy formation
The Galaxy And Mass Assembly (GAMA) project is the latest in a tradition of
large galaxy redshift surveys, and is now underway on the 3.9m Anglo-Australian
Telescope at Siding Spring Observatory. GAMA is designed to map extragalactic
structures on scales of 1kpc - 1Mpc in complete detail to a redshift of z~0.2,
and to trace the distribution of luminous galaxies out to z~0.5. The principal
science aim is to test the standard hierarchical structure formation paradigm
of Cold Dark Matter (CDM) on scales of galaxy groups, pairs, discs, bulges and
bars. We will measure (1) the Dark Matter Halo Mass Function (as inferred from
galaxy group velocity dispersions); (2) baryonic processes, such as star
formation and galaxy formation efficiency (as derived from Galaxy Stellar Mass
Functions); and (3) the evolution of galaxy merger rates (via galaxy close
pairs and galaxy asymmetries). Additionally, GAMA will form the central part of
a new galaxy database, which aims to contain 275,000 galaxies with
multi-wavelength coverage from coordinated observations with the latest
international ground- and space-based facilities: GALEX, VST, VISTA, WISE,
HERSCHEL, GMRT and ASKAP. Together, these data will provide increased depth
(over 2 magnitudes), doubled spatial resolution (0.7"), and significantly
extended wavelength coverage (UV through Far-IR to radio) over the main SDSS
spectroscopic survey for five regions, each of around 50 deg^2. This database
will permit detailed investigations of the structural, chemical, and dynamical
properties of all galaxy types, across all environments, and over a 5 billion
year timeline.Comment: GAMA overview which appeared in the October 2009 issue of Astronomy &
Geophysics, ref: Astron.Geophys. 50 (2009) 5.1
Galaxy and mass assembly (GAMA): The connection between metals, specific SFR and Hi gas in galaxies: The Z-SSFR relation
We study the interplay between gas phase metallicity (Z), specific star formation rate (SSFR) and neutral hydrogen gas (HI) for galaxies of different stellar masses. Our study uses spectroscopic data from Galaxy and Mass Assembly and Sloan Digital Sky Su
Infrequent Detection of KI, WU and MC Polyomaviruses in Immunosuppressed Individuals with or without Progressive Multifocal Leukoencephalopathy
Conflicting prevalence of newly identified KI(KIPyV), WU(WUPyV) and Merkel Cell Carcinoma(MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy(PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence of these polyomaviruses in cerebrospinal fluid(CSF), peripheral blood mononuclear cells(PBMC), and bone marrow samples from PML patients, immunosuppressed individuals with or without HIV, and multiple sclerosis(MS) patients. Distinct PCR tests for KIPyV, WUPyV and MCPyV DNA performed in two independent laboratories detected low levels of MCPyV DNA only in 1/269 samples. The infrequent detections of these viruses in multiple samples from immunosuppressed individuals including those with PML suggest that their reactivation mechanisms may be different from that of JC polyomavirus (JCPyV) and that they do not play a role in the pathogenesis of PML
Can Interventional Cardiologists Help Deliver the UK Mechanical Thrombectomy Interventional Programme for Patients with Acute Ischaemic Stroke? A Discussion Paper from the British Cardiovascular Interventional Society Stroke Thrombectomy Focus Group
There is a willingness among UK interventional cardiologists to contribute to provision of a 24/7 mechanical thrombectomy (MT) service for all suitable stroke patients if given the appropriate training. This highly effective intervention remains unavailable to the majority of patients who might benefit, partly because there is a limited number of trained specialists. As demonstrated in other countries, interdisciplinary working can be the solution and an opportunity to achieve this is outlined in this article
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