A Bundled Approach to Explaining Technological Change: The Case of E-estonia

Explaining change is an abstract endeavor. Many management scholars have adopted metaphors to explain change. In this paper, we discuss technological change. We use a historical and theoretical approach to review and elaborate on concepts and context about a specific case. We discuss the limitations of each approach proffered and the implications thusly on technological change. We present plurality and multiplicity of perspectives through socio-technical lens to explain technological change contextually on an organizational level. We show by using our model how technology absorption and diffusion can be accelerated through artefactual institutions to engineer social change. The multiplicity of perspectives and plurality of our arguments creates a fine explanation of the e-Estonia case as an example. Keywords: artefactual institutions, e-Estonia, social change, technological trajectorie

Heterogeneous returns and the persistence of agricultural technology adoption

In this paper we explore whether low rates of sustained technology use can be explained by heterogeneity in returns to adoption. To do so we evaluate impacts of the Cocoa Abrabopa Association, which provided a package of fertilizer and other inputs on credit to cocoa farmers in Ghana. High estimated average productive impacts for treated farmers are found to be consistent with negative economic profits for a substantial proportion of the treated population. By constructing an individual specific measure of returns,we demonstrate that low realized returns among adopters are associated with low retention rates, even after conditioning on output levels and successful repayment. The results are consistent with the hypothesis that high average returns mask substantial and persistent heterogeneity, and that farmers experiment in order to learn about their idiosyncratic returns.

Strategies to Reduce the Impact of Resource Consumption in the Ghanaian Construction Industry

With a growing priority on resolving environmental issues and managing resources more effectively in line with Sustainable Development Goal 12, this research aims to assess solutions to minimize resource consumption in the Ghanaian construction sector. In the Ghanaian cities of Accra and Kumasi, questionnaires were utilized to solicit responses from construction stakeholders. Mean score ranking was used to rank these techniques. A reliability analysis using Cronbach's alpha coefficient found a high level of internal consistency. A high level of agreement was found after testing using Kendall's concordance. A one-sample t-test was also employed to examine the relative importance of the variables. Properties should be built to be disassembled; sections of existing building structures should be reused; prefabricated components should be utilized for on-site assembly; demolition components should be re-used or recycled, and existing buildings should be renovated to prevent destruction. This research is valuable because it adds to a checklist of measures for minimizing the effect of resource consumption in the Ghanaian construction sector, as well as to the achievement of the SDG goal. Project managers, architects, engineers, subcontractors, and other key stakeholders are encouraged to use innovative approaches to decrease resource consumption

Strategies to Reduce the Impact of Resource Consumption in the Ghanaian Construction Industry

With a growing priority on resolving environmental issues and managing resources more effectively in line with Sustainable Development Goal 12, this research aims to assess solutions to minimize resource consumption in the Ghanaian construction sector. In the Ghanaian cities of Accra and Kumasi, questionnaires were utilized to solicit responses from construction stakeholders. Mean score ranking was used to rank these techniques. A reliability analysis using Cronbach's alpha coefficient found a high level of internal consistency. A high level of agreement was found after testing using Kendall's concordance. A one-sample t-test was also employed to examine the relative importance of the variables. Properties should be built to be disassembled; sections of existing building structures should be reused; prefabricated components should be utilized for on-site assembly; demolition components should be re-used or recycled, and existing buildings should be renovated to prevent destruction. This research is valuable because it adds to a checklist of measures for minimizing the effect of resource consumption in the Ghanaian construction sector, as well as to the achievement of the SDG goal. Project managers, architects, engineers, subcontractors, and other key stakeholders are encouraged to use innovative approaches to decrease resource consumption

The Challenges of Sustainable Development on Facilities Management Outsourcing Services: An Investigation in Educational Facilities

((1) Background: Generally, firms are reluctant to report outsourcing failures, no matter what industry they operate within. To eliminate poor performance of outsourced service providers, it is necessary to establish a specific outsourcing relationship model for facilities management (FM). The purpose of this paper is to study the concept of outsourcing relationships in relation to FM and to investigate the design of the critical success factors on sustainable outsourcing strategies through a discussion of four dimensions (ownership of FM assets, control of FM assets, competitive position and long-term plan). (2) Methods: Based on two questionnaire surveys, data were collected from 38 clients and 34 service providers. The study evaluated the FM outsourcing strategies from critical success factors in educational facilities in Hong Kong. (3) Results: This study explains the impact of FM outsourcing strategies on Hong Kong’s four commonly outsourced FM contracts including building maintenance, security, cleaning and catering from the clients’ and service providers’ point of view. (4) Conclusions: This is the outsourcing way forward in order to create a better working environment conducive for all the parties that would result in better sustainability of FM’s future and thus impact the economic objectives of sustainable development, in parallel with adding social and environmental value

Triterpenoids from Protorhus longifolia exhibit hypocholesterolemic potential via regulation of cholesterol biosynthesis and stimulation of low-density lipoprotein uptake in HepG2 cells

The increasing incidence of hypercholesterolemia-related diseases even in the presence of the currently available cholesterol-lowering drugs indicates a need to discover new therapeutic drugs. This study aimed to investigate the hypocholesterolemic potential of two triterpenoids isolated from Protorhus longifolia stem bark. In silico techniques and in vitro enzyme assays were used to evaluate the potential inhibition of cholesterol esterase and HMGCoA reductase by the triterpenoids (ARM-2 and RA-5). The toxicity, modulation of low-density lipoprotein (LDL) uptake, and associated gene expression were determined in HepG2 hepatocytes. In silico molecular docking revealed that ARM-2 compared with RA-5 has a relatively stronger binding affinity for both enzymes. Both triterpenoids further demonstrated promising in silico drug-likeness properties and favorable ADMET profiles characterized by high intestinal absorption and lack of CYP450 enzyme inhibition. The compounds further showed, to varying degrees of efficacy, inhibition of cholesterol micellization as well as both cholesterol esterase and HMG-CoA reductase activities with IC50 values ranging from 16.4 to 41.1 μM. Moreover, enhanced hepatic cellular LDL uptake and the associated upregulation of the LDL-R and SREBP-2 gene expression were observed in the triterpenoid-treated HepG2 cells. It is evident that the triterpenoids, especially ARM-2, possess hypocholesterolemic properties, and these molecules can serve as leads or structural templates for the development of new hypocholesterolemic drugs.http://pubs.acs.org/journal/acsodfam2024AnatomyBiochemistryGeneticsMicrobiology and Plant PathologyNon

In vitro antioxidant and antidiabetic potential of crude extracts from the seed coat and fruit pulp of Strychnos madagascariensis

Please read abstract in the article.The Research Office, University of Zululand, South Africahttps://www.phcogj.comhj2021Biochemistr

The need for communication between researchers and policymakers for the deployment of bioengineered carbon capture and sequestration crops

Bioengineered/genome-edited carbon capture and sequestration (BE/GEd-CCS) crops are being developed to mitigate climate change. This paper explores how technology, regulation, funding, and social implications, could shape the development and deployment of these crops. We conclude that some of the technological efforts to create BE/GEd-CCS crops may work. Still, stakeholders must agree on generally accepted methods of measuring how much carbon is captured in the soil and its value. The regulatory space for BE/GEd-CCS crops remains fluid until the first crops are reviewed. BE/GEd-CCS crops have received considerable initial funding and may benefit financially more from other federal programs and voluntary carbon markets. BE/GEd-CCS crops may continue perpetuating social equity concerns about agricultural biotechnology due to a lack of oversight. We argue that stakeholders need to pursue a multidisciplinary view of BE/GEd-CCS crops that draw in varying perspectives for effective development and deployment. Communication is needed between researchers and policymakers involved in either developing BE/GEd-CCS crops or developing voluntary carbon markets. We argue for the start of a conversation both across disciplines and between researchers and policymakers about the development and deployment of BE/GEd-CCS crops

SAVVY® (C31G) Gel for Prevention of HIV infection in Women: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Ghana

The objective of this trial was to determine the effectiveness of 1.0% C31G (SAVVY) in preventing male-to-female vaginal transmission of HIV infection among women at high risk.This was a Phase 3, double-blind, randomized, placebo-controlled trial. Participants made up to 12 monthly visits for HIV testing, adverse event reporting, and study product supply. The study was conducted between March 2004 and February 2006 in Accra and Kumasi, Ghana. We enrolled 2142 HIV-negative women at high risk of HIV infection, and randomized them to SAVVY or placebo gel. Main outcome measures were the incidence of HIV-1 and HIV-2 infection as determined by detection of HIV antibodies from oral mucosal transudate specimens and adverse events. We accrued 790 person-years of follow-up in the SAVVY group and 772 person-years in the placebo group. No clinically significant differences in the overall frequency of adverse events, abnormal pelvic examination findings, or abnormal laboratory results were seen between treatment groups. However, more participants in the SAVVY group reported reproductive tract adverse events than in the placebo group (13.0% versus 9.4%). Seventeen HIV seroconversions occurred; eight in participants randomized to SAVVY and nine in participants receiving placebo. The Kaplan-Meier estimates of the cumulative probability of HIV infection through 12 months were 0.010 in the SAVVY group and 0.011 in the placebo group (p = 0.731), with a hazard ratio (SAVVY versus placebo) of 0.88 (95% confidence interval 0.33, 2.27). Because of a lower-than-expected HIV incidence, we were unable to achieve the required number of HIV infections (66) to obtain the desired study power.SAVVY was not associated with increased adverse events overall, but was associated with higher reporting of reproductive adverse events. Our data are insufficient to conclude whether SAVVY is effective at preventing HIV infection relative to placebo.ClinicalTrials.gov NCT00129532

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London