The Veterans Affairs Neuropathy Scale: A Reliable, Remote Polyneuropathy Exam.

Introduction: Polyneuropathy (PN) complaints are common, prompting many referrals for neurologic evaluation. To improve access of PN care in distant community clinics, we developed a telemedicine service (patient-clinician interactions using real-time videoconference technology) for PN. The primary goal of this study was to construct a remote exam for PN that is feasible, reliable, and concordant with in-person assessments for use in our tele-PN clinics. Methods: To construct the VA Neuropathy Scale (VANS), we searched the literature for existing, validated PN assessments. From these assessments, we selected a parsimonious set of exam elements based on literature-reported sensitivity and specificity of PN detection, with modifications as necessary for our teleneurology setting (i.e., a technician examination under the direction of a neurologist). We recruited 28 participants with varying degrees of PN to undergo VANS testing under 5 scenarios. The 5 scenarios differed by mode of VANS grading (in-person vs. telemedicine) and by the in-person examiner type (neurologist vs. technician) in telemedicine scenarios. We analyzed concordance between the VANS and a person's medical chart-derived PN status by modeling the receiver operating characteristic (ROC) curve. We analyzed reliability of the VANS by mixed effects regression and computing the intraclass correlation coefficient (ICC) of scores across the 5 scenarios. Results: The VA Neuropathy Scale (VANS) tests balance, gait, reflexes, foot inspection, vibration, and pinprick. Possible scores range from 0 to 50 (worst). From the ROC curve, a cutoff of >2 points on the VANS sets the sensitivity and specificity of detecting PN at 98 and 91%, respectively. There is a small (1.3 points) but statistically significant difference in VANS scoring between in-person and telemedicine grading scenarios. For telemedicine grading scenarios, there is no difference in VANS scores between neurologist and technician examinations. The ICC is 0.89 across all scenarios. Discussion: The VANS, informed by existing PN instruments, is a promising clinical assessment tool for diagnosing and monitoring the severity of PN in telemedicine settings. This pilot study indicates acceptable concordance and reliability of the VANS with in-person examinations

Melanism as a potential thermal benefit in eastern fox squirrels (Sciurus niger)

Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas. The selective advantage of melanism is currently unknown, but thermal advantages have been hypothesized, especially in winter. No difference in metabolic response curves were measured between melanistic (black) and rufus (orange) fox squirrels. When exposed to sunny skies, both melanistic and rufus squirrels had higher surface (skin and fur) temperature as ambient temperatures increased. Melanistic squirrel surface temperatures did not differ when squirrels were exposed to sunny or cloudy skies. However, rufus individuals showed significantly lower increases in surface temperatures when under cloudy skies. During fall months, rufus individuals were about 1.5 times more active throughout the day than melanistic individuals. However, in winter, melanistic fox squirrels were approximately 30% more active in the mornings (before 13:00) compared to rufus squirrels. Pre-winter body condition was higher in melanistic (25.5 ± 1.8 g/cm) compared to rufus (20.30 ± 3.6 g/cm) fox squirrels; however, there were no significant differences between melanistic (22.8 ± 1.4 g/cm) and rufus (23.9 ± 0.8 g/cm) fox squirrel post-winter body condition. The results of this study indicate that melanistic fox squirrels may have a slight winter thermal advantage over rufus fox squirrels by maintaining higher skin temperatures

Generalized Wilson Chain for solving multichannel quantum impurity problems

The Numerical Renormalization Group is used to solve quantum impurity problems, which describe magnetic impurities in metals, nanodevices, and correlated materials within DMFT. Here we present a simple generalization of the Wilson Chain, which improves the scaling of computational cost with the number of channels/bands, bringing new problems within reach. The method is applied to calculate the t-matrix of the three-channel Kondo model at T=0, which shows universal crossovers near non-Fermi liquid critical points. A non-integrable three-impurity problem with three bands is also studied, revealing a rich phase diagram and novel screening/overscreening mechanisms.Comment: 5 pages + 5 pages supplementary materia

Animal Management and Population Control, What Progress Have We Made?

Evaluations of animal population problems and their solutions by ten regional animal control and humane society shelters.https://www.wellbeingintlstudiesrepository.org/ebooks/1002/thumbnail.jp

Role of Peptide Backbone Conformation on Biological Activity of Chemotactic Peptides

To investigate the role of peptide backbone conformation on the biological activity of chemotactic peptides, we synthesized a unique analog of N-formyl-Met-Leu-Phe-OH incorporating the C α,α disubstituted residue, dipropylglycine (Dpg) in place of Leu. The conformation of the stereochemically constrained Dpg analog was examined in the crystalline state by x-ray diffraction and in solution using NMR, IR, and CD methods. The secretagogue activity of the peptide on human neutrophils was determined and compared with that of a stereochemically constrained, folded type II β-turn analog incorporating 1-aminocyclohexanecarboxylic acid (Ac6c) at position 2 (f-Met- Ac6c -Phe-OMe), the parent peptide (f-Met-Leu-Phe-OH) and its methyl ester derivative (f-Met-Leu-Phe-OMe). In the solid state, the Dpg analog adopts an extended β-sheet-like structure with an intramolecular hydrogen bond between the NH and CO groups of the Dpg residue, thereby forming a fully extended (C5) conformation at position 2. The ϕ and ψ values for Met and Phe residues are significantly lower than the values expected for an ideal antiparallel beta conformation causing a twist in the extended backbone both at the N and C termini. Nuclear magnetic resonance studies suggest the presence of a significant population of the peptide molecules in an extended antiparallel β conformation and the involvement of Dpg NH in a C5 intramolecular hydrogen bond in solutions of deuterated chloroform and deuterated dimethyl sulfoxide. IR studies provide evidence for the presence of an intramolecular hydrogen bond in the molecule and the antiparallel extended conformation in chloroform solution. CD spectra in methanol, trifluoroethanol, and trimethyl phosphate indicate that the Dpg peptide shows slight conformational flexibility, whereas the folded Ac6c analog is quite rigid. The extended Dpg peptide consistently shows the highest activity in human peripheral blood neutrophils, being approximately 8 and 16 times more active than the parent peptide and the folded Ac6c analog, respectively. However, the finding that all four peptides have ED50 (the molar concentration of peptide to induce half-maximal enzyme release) values in the 10(-8)-10(-9) M range suggests that an induced fit mechanism may indeed be important in this ligand-receptor interaction. Moreover, it is also possible that alterations in the backbone conformation at the tripeptide level may not significantly alter the side chain topography and/or the accessibility of key functional groups important for interaction with the receptor

Unsteady flow of a thixotropic fluid in a slowly varying pipe

We analyse the unsteady axisymmetric flow of a thixotropic or antithixotropic fluid in a slowly varying cylindrical pipe. We derive general perturbation solutions in regimes of small Deborah numbers, in which thixotropic or antithixotropic effects enter as perturbations to generalised Newtonian flow. We present results for the viscous Moore–Mewis–Wagner model and the viscoplastic Houška model, and we use these results to elucidate what can be predicted in general about the behaviour of thixotropic and antithixotropic fluids in lubrication flow. The range of behaviour we identify casts doubt on the efficacy of model reduction approaches that postulate a generic cross-pipe flow structure

Testing the robustness of optimal operating plans under various future hydro-climatic scenarios

A key challenge for water resources planning processes around the world is to develop operating plans that are optimal under a range of hydro-climatic conditions. The consequences of such long term planning decisions can vary in terms of the social, economic, and environmental impacts. Given these potential impacts, it is important that operating plans are tested under a range of hydro-climatic conditions to ensure that they are sufficiently robust to withstand future changes in climate. The aim of this study is to present a procedure for testing the robustness of optimal operating plans for complex water resources systems using a combined multi-objective optimisation and sustainability assessment approach. The approach embeds an optimisation-simulation (O-S) model which is applied to an 18-objective function multi-objective optimisation problem of the Wimmera-Mallee Water Supply System (WMWSS). The WMWSS is a multi-reservoir system located in Western Victoria (Australia) which is operated to meet a range of competing interests for water using complex operating rules. The O-S model is applied to the WMWSS to search for optimal operating plans over a 100-year period into the future assuming two plausible greenhouse gas (GHG) emission levels. The two GHG emission scenarios represent lower and higher ends of the estimated range of projected GHG emissions, providing a wide range of future hydro-climatic conditions. A robustness test is used to evaluate the validity of the most sustainable optimal operating plans under the two GHG emmission scenarios and also those found previously under a historic hydro-climatic sequence. The test results show that the status quo or base case operating plan is optimal but is neither the highest nor the lowest in terms of the level of sustainability that could be achieved in the WMWSS, under historic and the higher GHG emission scenario. Moreover, the results show that the most sustainable optimal operating plans found under the three hydro-climatic scenarios are sufficiently robust to withstand the full range of hydro-climatic conditions considered whereas the base case operating plan is not as robust. The risks involved in the implementation of operating plans which exhibit large deviations from the base case operating plan are discussed. These risks highlight the importance of problem formulation and sensitivity analysis of the optimal operating plans in order to find real world solutions to real world problems. © CURRAN-CONFERENCE. All rights reserved

Deep dielectric charging of regolith within the Moon\u27s permanently shadowed regions

Abstract Energetic charged particles, such as galactic cosmic rays (GCRs) and solar energetic particles (SEPs), can penetrate deep within the lunar surface, resulting in deep dielectric charging. This charging process depends on the GCR and SEP currents, as well as on the regolith\u27s electrical conductivity and permittivity. In permanently shadowed regions (PSRs) near the lunar poles, the discharging timescales are on the order of a lunation (∼20 days). We present the first predictions for deep dielectric charging of lunar regolith. To estimate the resulting subsurface electric fields, we develop a data-driven, one-dimensional, time-dependent model. For model inputs, we use GCR data from the Cosmic Ray Telescope for the Effects of Radiation on board the Lunar Reconnaissance Orbiter and SEP data from the Electron, Proton, and Alpha Monitor on the Advanced Composition Explorer. We find that during the recent solar minimum, GCRs create persistent electric fields up to ∼700 V/m. We also find that large SEP events create transient but strong electric fields (≥106 V/m) that may induce dielectric breakdown. Such breakdown would likely result in significant modifications to the physical and chemical properties of the lunar regolith within PSRs. Key Points Energetic charged particles deep dielectrically charge the lunar regolithWe model the resulting subsurface electric fieldsThe electric fields may be great enough to induce dielectric breakdown

Generation of strongly-coupled plasma using Argon-based capillary discharge lasers

Argon based capillary discharge lasers operate in the extreme ultra violet (EUV) at 46.9 nm with an output of up to 0.5 mJ energy per pulse and up to a 10 Hz repetition rate. Focussed irradiances of up to 1012 W cm-2 are achievable and can be used to generate plasma in the warm dense matter regime by irradiating solid material. To model the interaction between such an EUV laser and solid material, the 2D radiative-hydrodynamic code POLLUX has been modified to include absorption via direct photo-ionisation, a super-configuration model to describe the ionisation dependant electronic configurations and a calculation of plasma refractive indices for ray tracing of the incident EUV laser radiation. A simulation study is presented, demonstrating how capillary discharge lasers of 1.2ns pulse duration can be used to generate strongly coupled plasma at close to solid density with temperatures of a few eV and energy densities up to 1×105 J cm-3. Plasmas produced by EUV laser irradiation are shown to be useful for examining the equation-of-state properties of warm dense matter. One difficulty with this technique is the reduction of the strong temperature and density gradients which are produced during the interaction. Methods to inhibit and control these gradients will be examined

The X-ray Emissions from the M87 Jet: Diagnostics and Physical Interpretation

We reanalyze the deep Chandra observations of the M87 jet, first examined by Wilson & Yang (2002). By employing an analysis chain that includes image deconvolution, knots HST-1 and I are fully separated from adjacent emission. We find slight but significant variations in the spectral shape, with values of $\alpha_x$ ranging from $\sim 1.2-1.6$. We use VLA radio observations, as well as HST imaging and polarimetry data, to examine the jet's broad-band spectrum and inquire as to the nature of particle acceleration in the jet. As shown in previous papers, a simple continuous injection model for synchrotron-emitting knots, in which both the filling factor, $f_{acc}$, of regions within which particles are accelerated and the energy spectrum of the injected particles are constant, cannot account for the X-ray flux or spectrum. Instead, we propose that $f_{acc}$ is a function of position and energy and find that in the inner jet, $f_{acc} \propto E_\gamma^{-0.4 \pm 0.2} \propto E_e^{-0.2 \pm 0.1}$, and in knots A and B, $f_{acc} \propto E_\gamma^{-0.7 \pm 0.2} \propto E_e^{-0.35 \pm 0.1}$, where $E_\gamma$ is the emitted photon energy and and $E_e$ is the emitting electron energy. In this model, the index $p$ of the injected electron energy spectrum ($n(E_{e}) \propto E_{e}^{-p}$) is $p=2.2$ at all locations in the jet, as predicted by models of cosmic ray acceleration by ultrarelativistic shocks. There is a strong correlation between the peaks of X-ray emission and minima of optical percentage polarization, i.e., regions where the jet magnetic field is not ordered. We suggest that the X-ray peaks coincide with shock waves which accelerate the X-ray emitting electrons and cause changes in the direction of the magnetic field; the polarization is thus small because of beam averaging.Comment: Accepted for publication in ApJ; 21 pages, 9 figures, 2 tables; abstract shortened for astro-ph; Figures 1, 7 and 8 at reduced resolutio