COMPLACENT OR COMPETITIVE? BRITISH EXPORTERS AND THE DRIFT TO EMPIRE

The belief that Britain’s empire markets were soft is well entrenched in the literature. It is, however, a belief that has been largely untested. Indeed, the literature does not even offer an explicit definition of softness. This paper attempts to fill this gap by discussing the meaning of the term and, then, posing the question whether between 1870 and 1914 Britain’s fastest growing markets – Australasia and Canada – can in fact be reasonably labelled soft, as has often been assumed. The paper concludes that the demand for British imports in these markets were driven more by income and price considerations than by colonial sentiment or preference.Empire markets, soft markets, British exports, imperial sentiments

High-resolution Spectroscopy of Extremely Metal-poor Stars in the Least Evolved Galaxies: Leo IV

We present high-resolution Magellan/MIKE spectroscopy of the brightest star in the ultra-faint dwarf galaxy Leo IV. We measure an iron abundance of [Fe/H] = –3.2, adding to the rapidly growing sample of extremely metal-poor (EMP) stars being identified in Milky Way satellite galaxies. The star is enhanced in the α elements Mg, Ca, and Ti by ~0.3 dex, very similar to the typical Milky Way halo abundance pattern. All of the light and iron-peak elements follow the trends established by EMP halo stars, but the neutron-capture elements Ba and Sr are significantly underabundant. These results are quite similar to those found for stars in the ultra-faint dwarfs Ursa Major II, Coma Berenices, Boötes I, and Hercules, suggesting that the chemical evolution of the lowest-luminosity galaxies may be universal. The abundance pattern we observe is consistent with predictions for nucleosynthesis from a Population III supernova explosion. The extremely low metallicity of this star also supports the idea that a significant fraction (≳10%) of the stars in the faintest dwarfs have metallicities below [Fe/H] = –3.0

Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?

Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60-70% of the 50 million worldwide cases of dementia and is characterised by cognitive impairments, many of which have long been associated with dysfunction of the cholinergic system. Although the M muscarinic acetylcholine receptor (mAChR) is considered a promising drug target for AD, ligands targeting this receptor have so far been unsuccessful in clinical trials. As modulatory receptors to cholinergic transmission, the endocannabinoid system may be a promising drug target to allow fine tuning of the cholinergic system. Furthermore, disease-related changes have been found in the endocannabinoid system during AD progression and indeed targeting the endocannabinoid system at specific disease stages alleviates cognitive symptoms in numerous mouse models of AD. Here we review the role of the endocannabinoid system in AD, and its crosstalk with mAChRs as a potential drug target for cholinergic dysfunction. [Abstract copyright: Copyright © 2019. Published by Elsevier Inc.

Environmental, developmental, and genetic factors controlling root system architecture

A better understanding of the development and architecture of roots is essential to develop strategies to increase crop yield and optimize agricultural land use. Roots control nutrient and water uptake, provide anchoring and mechanical support and can serve as important storage organs. Root growth and development is under tight genetic control and modulated by developmental cues including plant hormones and the environment. This review focuses on root architecture and its diversity and the role of environment, nutrient, and water as well as plant hormones and their interactions in shaping root architecture

A Puzzle Involving Galactic Bulge Microlensing Events

We study a sample of 16 microlensed Galactic bulge main sequence turnoff region stars for which high dispersion spectra have been obtained with detailed abundance analyses. We demonstrate that there is a very strong and highly statistically significant correlation between the maximum magnification of the microlensed bulge star and the value of the [Fe/H] deduced from the high resolution spectrum of each object. Physics demands that this correlation, assuming it to be real, be the result of some sample bias. We suggest several possible explanations, but are forced to reject them all,and are left puzzled. To obtain a reliable metallicity distribution in the Galactic bulge based on microlensed dwarf stars it will be necessary to resolve this issue through the course of additional observations.Comment: Submitted to ApJL, table 2 (quite long) will only appear in the on-line version of ApJ

The Neutron Star Crust: Nuclear Physics Input

A fully self-consistent model of the neutron star inner crust based upon models of the nucleonic equation of state at zero temperature is constructed. The results nearly match those of previous calculations of the inner crust given the same input equation of state. The extent to which the uncertainties in the symmetry energy, the compressibility, and the equation of state of low-density neutron matter affect the composition of the crust are examined. The composition and pressure of the crust is sensitive to the description of low-density neutron matter and the nuclear symmetry energy, and the latter dependence is non-monotonic, giving larger nuclei for moderate symmetry energies and smaller nuclei for more extreme symmetry energies. Future nuclear experiments may help constrain the crust and future astrophysical observations may constrain the nuclear physics input.Comment: 9 pages, 8 figures. Submitted to PR

Perceptual integration for qualitatively different 3-D cues in the human brain.

The visual system's flexibility in estimating depth is remarkable: We readily perceive 3-D structure under diverse conditions from the seemingly random dots of a "magic eye" stereogram to the aesthetically beautiful, but obviously flat, canvasses of the Old Masters. Yet, 3-D perception is often enhanced when different cues specify the same depth. This perceptual process is understood as Bayesian inference that improves sensory estimates. Despite considerable behavioral support for this theory, insights into the cortical circuits involved are limited. Moreover, extant work tested quantitatively similar cues, reducing some of the challenges associated with integrating computationally and qualitatively different signals. Here we address this challenge by measuring fMRI responses to depth structures defined by shading, binocular disparity, and their combination. We quantified information about depth configurations (convex "bumps" vs. concave "dimples") in different visual cortical areas using pattern classification analysis. We found that fMRI responses in dorsal visual area V3B/KO were more discriminable when disparity and shading concurrently signaled depth, in line with the predictions of cue integration. Importantly, by relating fMRI and psychophysical tests of integration, we observed a close association between depth judgments and activity in this area. Finally, using a cross-cue transfer test, we found that fMRI responses evoked by one cue afford classification of responses evoked by the other. This reveals a generalized depth representation in dorsal visual cortex that combines qualitatively different information in line with 3-D perception