A Positive Resampler for Monte Carlo events with negative weights

We propose the Positive Resampler to solve the problem associated with event samples from state-of-the-art predictions for scattering processes at hadron colliders typically involving a sizeable number of events contributing with negative weight. The proposed method guarantees positive weights for all physical distributions, and a correct description of all observables. A desirable side product of the method is the possibility to reduce the size of event samples produced by General Purpose Event Generators, thus lowering the resource demands for subsequent computing-intensive event processing steps. We demonstrate the viability and efficiency of our approach by considering its application to a next-to-leading order + parton shower merged prediction for the production of a W boson in association with multiple jets

Synthese und Anwendung eines photoschaltbaren zellgängigen Peptids & Struktur, Dynamik und Funktion der LIM2/3 Tandem-Domäne des Proteins Paxillin

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"So genau wie möglich und so frei wie nötig". Was ist beim Übersetzen des Neuen Testaments möglich und was ist nötig?

Prestel P. "So genau wie möglich und so frei wie nötig". Was ist beim Übersetzen des Neuen Testaments möglich und was ist nötig? Theologische Rundschau. 2011;76(3):361-387

Übersetzung und Interpretation der Epigramme 10, 23. 29. 55. 75.

Prestel P. Übersetzung und Interpretation der Epigramme 10, 23. 29. 55. 75. In: Damschen G, Heil A, eds. Martialis epigrammaton liber decimus. Das zehnte Epigrammbuch. Text, Übersetzung, Interpretationen. Studien zur klassischen Philologie. Vol 148. Frankfurt: Lang; 2004: 507

A new approach to metal- and polymer-recovery from metallized plastic waste using mechanical treatment and subcritical solvents: submitted, in review

Galvanized or “chromium-plated” plastics are well known to the consumer from the automotive sector and sanitary area. Polymers such as acrylonitrile butadiene styrene (ABS) are typically coated with a layer system of chromium, nickel and copper to obtain the characteristic optical surface and resistance properties. Due to the complex manufacturing process and high quality requirements, the production of these plastic metal composites generates 10–30% of rejects. We, therefore, developed an innovative process cascade for the recovery of both components (metal and polymer) applying established technologies (mechanical pre-treatment, classification, melt filtration, CreaSolv® Process) and were able to obtain ABS regranulate having excellent properties regarding the characteristic values for strength but slight compromises in impact characteristics. Blends with different amounts of virgin ABS, virgin PC and recycled ABS material as well as the pure cases were successfully re-metallized, all of them passing adhesion test, thermal shock resistance and CASS test. The high purity of the recovered materials led to increased redemption prices for metal and polymer by a factor of 6 and 2.5, respectively. Thus, the value added of metallized plastic waste is maximized, revealing a highly positive economic prognosis of a commercial implementation of the developed process—even at moderate scale

Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2

Slow conformational changes are often directly linked to protein function. It is however less clear how such processes may perturb the overall folding stability of a protein. We previously found that the stabilizing double mutant L49I/I57V in the small protein chymotrypsin inhibitor 2 from barley led to distributed increased nanosecond and faster dynamics. Here we asked what effects the L49I and I57V substitutions, either individually or together, have on the slow conformational dynamics of CI2. We used 15N CPMG spin relaxation dispersion experiments to measure the kinetics, thermodynamics, and structural changes associated with slow conformational change in CI2. These changes result in an excited state that is populated to 4.3% at 1°C. As the temperature is increased the population of the excited state decreases. Structural changes in the excited state are associated with residues that interact with water molecules that have well defined positions and are found at these positions in all crystal structures of CI2. The substitutions in CI2 have only little effect on the structure of the excited state whereas the stability of the excited state to some extent follows the stability of the main state. The minor state is thus most populated for the most stable CI2 variant and least populated for the least stable variant. We hypothesize that the interactions between the substituted residues and the well-ordered water molecules links subtle structural changes around the substituted residues to the region in the protein that experience slow conformational changes

Transcription of histone gene cluster by differential core-promoter factors

The 100 copies of tandemly arrayed Drosophila linker (H1) and core (H2A/B and H3/H4) histone gene cluster are coordinately regulated during the cell cycle. However, the molecular mechanisms that must allow differential transcription of linker versus core histones prevalent during development remain elusive. Here, we used fluorescence imaging, biochemistry, and genetics to show that TBP (TATA-box-binding protein)-related factor 2 (TRF2) selectively regulates the TATA-less Histone H1 gene promoter, while TBP/TFIID targets core histone transcription. Importantly, TRF2-depleted polytene chromosomes display severe chromosomal structural defects. This selective usage of TRF2 and TBP provides a novel mechanism to differentially direct transcription within the histone cluster. Moreover, genome-wide chromatin immunoprecipitation (ChIP)-on-chip analyses coupled with RNA interference (RNAi)-mediated functional studies revealed that TRF2 targets several classes of TATA-less promoters of >1000 genes including those driving transcription of essential chromatin organization and protein synthesis genes. Our studies establish that TRF2 promoter recognition complexes play a significantly more central role in governing metazoan transcription than previously appreciated

A study of multi-jet production in association with an electroweak vector boson

We consider the production of a single $Z$ or $W$ boson in association with jets at the LHC. We compute the corresponding cross sections by matching NLO QCD predictions with the Herwig++ and Pythia8 parton showers, and by merging all of the underlying matrix elements with up to two light partons at the Born level. We compare our results with several 7-TeV measurements by the ATLAS and CMS collaborations, and overall we find a good agreement between theory and data.We consider the production of a single Z or W boson in association with jets at the LHC. We compute the corresponding cross sections by matching NLO QCD predictions with the Herwig++ and Pythia8 parton showers, and by merging all of the underlying matrix elements with up to two light partons at the Born level. We compare our results with several 7-TeV measurements by the ATLAS and CMS collaborations, and overall we find a good agreement between theory and data.We consider the production of a single $Z$ or $W$ boson in association with jets at the LHC. We compute the corresponding cross sections by matching NLO QCD predictions with the Herwig++ and Pythia8 parton showers, and by merging all of the underlying matrix elements with up to two light partons at the Born level. We compare our results with several 7-TeV measurements by the ATLAS and CMS collaborations, and overall we find a good agreement between theory and data