Influence of combined physical and cognitive training on cognition: a systematic review

Background: Numerous daily activities require simultaneous application of motor and cognitive skills (dual-tasking). The execution of such tasks is especially difficult for the elderly and for people with (neuro-) degenerative disorders. Training of physical and cognitive abilities helps prevent or slow down the age-related decline of cognition. The aim of this review is to summarise and assess the role of combined physical-and-cognitive-training characteristics in improving cognitive performance and to propose an effective training scheme within the frame of a suitable experimental design. Methods: A systematic electronic literature search was conducted in selected databases. The following criteria were compulsory for inclusion in the study: 1. A (Randomized) Controlled Trial (RCT or CT) design; 2. Implementation of combined physical and cognitive training, either simultaneously (dual task) or subsequently - at least one hour per weekly over four weeks or more; 3. Cognitive outcomes as a study’s endpoint. Results: Twenty articles met the inclusion criteria. It appears that either simultaneous or subsequently combined physical and cognitive training is more successful compared to single physical or single cognitive exercise. Training characteristics like length, frequency, duration, intensity and level of task difficulty seem to determine cognitive performance. However, the articles show that cognitive improvement seems to remain somewhat confined to trained cognitive functions rather than generalising to other cognitive or daily-living skills. Conclusion: Due to methodological heterogeneity among studies, results need to be treated with caution. We critically discuss the role of training characteristics and propose a potentially effective training intervention within an appropriate experimental design

Comparison of postural stability and regulation among male athletes from different sports

The purpose of this study was to assess the postural control of 50 male athletes (age: 24.9 ± 4.55 years) who participate in different elite-level competitive sports. Athletes from two team sports from the third German league (ice hockey: n = 16; soccer: n = 23), and one individual sports (diving: n = 11) were included. These athletes were investigated using posturography under different conditions (e.g., stable surface, unstable surface; eyes open, eyes closed) to determine postural stability and regulation. Most of the performance maxima were found among the divers (6), followed by ice hockey (5) and soccer (4). The biggest effect of sport was found in the stability indicator, where the subject was standing on a stable surface and their eyes were closed (NC; p = 0.001, ηp2 = 0.273). This significance was observed between the soccer (17.3 ± 5.66) and diving (24.9 ± 6.98) subjects. The stability indicator had the largest significant effect (50%, 2/4). These results provide coaches and athletes insight into the postural stability and regulation of male athletes in sports with different demands on postural control. Especially for soccer players, it may be beneficial to address muscular imbalances to reduce the risk of lower extremity injuries

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

Objectives Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenz pharmacokinetics. Since the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) correlate with CYP2B6 in liver, and a CAR polymorphism (rs2307424) and smoking correlate with efavirenz plasma concentrations, we investigated their association with early (<3 months) discontinuation of efavirenz therapy. Methods Three hundred and seventy-three patients initiating therapy with an efavirenz-based regimen were included (278 white patients and 95 black patients; 293 male). DNA was extracted from whole blood and genotyping for CYP2B6 (516G → T, rs3745274), CAR (540C → T, rs2307424) and PXR (44477T → C, rs1523130; 63396C → T, rs2472677; and 69789A → G, rs763645) was conducted. Binary logistic regression using the backwards method was employed to assess the influence of SNPs and demographics on early discontinuation. Results Of the 373 patients, 131 withdrew from therapy within the first 3 months. Black ethnicity [odds ratio (OR) = 0.27; P = 0.0001], CYP2B6 516TT (OR = 2.81; P = 0.006), CAR rs2307424 CC (OR = 1.92; P = 0.007) and smoking status (OR = 0.45; P = 0.002) were associated with discontinuation within 3 months. Conclusions These data indicate that genetic variability in CYP2B6 and CAR contributes to early treatment discontinuation for efavirenz-based antiretroviral regimens. Further studies are now required to define the clinical utility of these association

Definitions and methods of measuring and reporting on injurious falls in randomised controlled fall prevention trials: a systematic review

<p>Abstract</p> <p>Background</p> <p>The standardisation of the assessment methodology and case definition represents a major precondition for the comparison of study results and the conduction of meta-analyses. International guidelines provide recommendations for the standardisation of falls methodology; however, injurious falls have not been targeted. The aim of the present article was to review systematically the range of case definitions and methods used to measure and report on injurious falls in randomised controlled trials (RCTs) on fall prevention.</p> <p>Methods</p> <p>An electronic literature search of selected comprehensive databases was performed to identify injurious falls definitions in published trials. Inclusion criteria were: RCTs on falls prevention published in English, study population ≥ 65 years, definition of injurious falls as a study endpoint by using the terms "injuries" and "falls".</p> <p>Results</p> <p>The search yielded 2089 articles, 2048 were excluded according to defined inclusion criteria. Forty-one articles were included. The systematic analysis of the methodology applied in RCTs disclosed substantial variations in the definition and methods used to measure and document injurious falls. The limited standardisation hampered comparability of study results. Our results also highlight that studies which used a similar, standardised definition of injurious falls showed comparable outcomes.</p> <p>Conclusions</p> <p>No standard for defining, measuring, and documenting injurious falls could be identified among published RCTs. A standardised injurious falls definition enhances the comparability of study results as demonstrated by a subgroup of RCTs used a similar definition. Recommendations for standardising the methodology are given in the present review.</p

Schwindel (Campus-Report)

Wenn sich alles um einen herum dreht, kann das an der letzten Party liegen oder am Verliebtsein. Muss es aber nicht. Schwindel gehört zu den häufigsten Beschwerden, die Menschen zum Arzt führen. Dr. Andreas Lauenroth, Wissenschaftler am Netzwerk Alternsforschung der Universität Heidelberg, hat herausgefunden, wie man vielen Schwindel-Patienten ohne Nebenwirkungen helfen kann. "Campus-Report" heißt die Radiosendung der Universitäten Heidelberg, Mannheim, Karlsruhe und Freiburg. Die Reportagen über aktuelle Themen aus Forschung und Wissenschaft werden montags bis freitags jeweils um ca. 19.10h im Programm von Radio Regenbogen gesendet

Testanzug „GERT“

Für eine Studie zu den Auswirkungen körperlicher Beeinträchtigungen im Alter untersucht das Netzwerk AlternsfoRschung Veränderungen des Gangbilds mit Hilfe eines Alterssimulationsanzugs. "Campus-Report" heißt die Radiosendung der Universitäten Heidelberg, Mannheim, Karlsruhe und Freiburg. Die Reportagen über aktuelle Themen aus Forschung und Wissenschaft werden montags bis freitags jeweils um ca. 19.10h im Programm von Radio Regenbogen gesendet. (Empfang in Nordbaden: UKW 102,8. In Mittelbaden: 100,4 und in Südbaden: 101,1

Schwindel: Durch Training wieder ins Gleichgewicht

Schwindel stellt für betroffene Patienten ein ernstes, aber kein lebensbedrohliches Phänomen dar. Bis zur genauen Diagnose vergehen nicht selten Wochen oder sogar Monate. Die auftretenden Gleichgewichtsstörungen und Begleiterscheinungen wie z.B. Übelkeit oder dauerhafter Drehschwindel führen in der Zwischenzeit oft zu Unsicherheiten und einer erhöhten Sturzgefahr. Bei einigen Schwindelformen hilft ein körperliches Training, das Sturzrisiko zu senken und damit auch die Alltagskompetenz und Sicherheit der betroffenen Patienten zu erhöhen. Im Vortrag werden die gut behandelbaren Schwindelformen erläutert und Wege aufgezeigt, wie man mit körperlichem Training – auch als Heimtraining - dem Schwindel begegnen kann. Der Referent dieses Vortrags ist der Sportwissenschaftler Dr. Andreas Lauenroth. Er leitet das Projekt "Age-Simulator" am Netzwerk Alternsforschung der Universität Heidelberg

Enhanced sprint performance analysis in soccer: New insights from a GPS-based tracking system.

The aim of this investigation was to establish the validity of a GPS-based tracking system (Polar Team Pro System, PTPS) for estimating sprint performance and to evaluate additional diagnostic indices derived from the temporal course of the movement velocity. Thirty-four male soccer players (20 ± 4 years) performed a 20 m sprint test measured by timing gates (TG), and while wearing the PTPS. To evaluate the relevance of additional velocity-based parameters to discriminate between faster and slower athletes, the median-split method was applied to the 20-m times. Practical relevance was estimated using standardized mean differences (d) between the subgroups. Differences between the criterion reference (TG) and PTPS for the 10 and 20 m splits did not vary from zero (dt10: -0.01 ± 0.07 s, P = 0.7, d < -0.1; dt20: -0.01 ± 0.08 s, P = 0.4, d < -0.2). Although subgroups revealed large differences in their sprint times (d = -2.5), the average accelerations between 5 and 20 km/h as well as 20 and 25 km/h showed merely small effects (d < 0.5). Consequently, analyses of velocity curves derived from PTPS may help to clarify the occurrence of performance in outdoor sports. Thus, training consequences can be drawn which contribute to the differentiation and individualization of sprint training

Do We Preach What We Practice? Investigating the Practical Relevance of Requirements Engineering Syllabi - The IREB Case

Nowadays, there exist a plethora of different educational syllabi for Requirements Engineering (RE), all aiming at incorporating practically relevant educational units (EUs). Many of these syllabi are based, in one way or the other, on the syllabi provided by the International Requirements Engineering Board (IREB), a non-profit organisation devoted to standardised certification programs for RE. IREB syllabi are developed by RE experts and are, thus, based on the assumption that they address topics of practical relevance. However, little is known about to what extent practitioners actually perceive those contents as useful. We have started a study to investigate the relevance of the EUs included in the IREB Foundation Level certification programme. In the first phase reported in this paper, we have surveyed practitioners mainly from DACH countries (Germany, Austria and Switzerland) who participated in the IREB certification. Later phases will widen the scope both by including other countries and by not requiring IREB-certified participants. The results shall foster a critical reflection on the practical relevance of EUs built upon the de-facto standard syllabus of IREB