The Role of Wearable Sensors in the Future Primary Healthcare - Preferences of the Adult Swiss Population: A Mixed Methods Approach.

Wearable sensors have the potential to increase continuity of care and reduce healthcare expenditure. The user concerns and preferences regarding wearable sensors are the least addressed topic in related literature. Therefore, this study aimed first, to examine the preferences of the adult Swiss population regarding the use of wearable sensors in primary healthcare. Second, the study aimed to explain and learn more about these preferences and why such wearable sensors would or would not be used. An explanatory sequential design was used to reach the two aims. In the initial quantitative phase preferences of a nationwide survey were analyzed descriptively and a multivariable ordered logistic regression was used to identify key characteristics, that influence the preferences. In the second phase, eight semi-structured interviews were conducted. The cleaned study sample of the survey included 687 participants, 46% of whom gave a positive rating regarding the use of wearable sensors. In contrast, 44% gave a negative rating and 10% were neutral. The interviews showed that sensors should be small, not flashy and be compatible with everyday activities. Individuals without a current health risk or existing chronic disease showed lower preferences for using wearable sensors, particularly because they fear losing control over their own body. In contrast, individuals with increased risk or with an existing chronic disease were more likely to use wearable sensors as they can increase the personal safety and provide real-time health information to physicians. Therefore, an important deciding factor for and against the use of wearable sensors seems to be the perceived personal susceptibility for potential health problems

Cognitive Representations and Cognitive Processing of Team-Specific Tactics in Soccer

Lex H, Essig K, Knoblauch A, Schack T. Cognitive Representations and Cognitive Processing of Team-Specific Tactics in Soccer. PLoS ONE. 2015;10(2): e0118219.Two core elements for the coordination of different actions in sport are tactical information and knowledge about tactical situations. The current study describes two experiments to learn about the memory structure and the cognitive processing of tactical information. Experiment 1 investigated the storage and structuring of team-specific tactics in humans’ long-term memory with regard to different expertise levels. Experiment 2 investigated tactical decision-making skills and the corresponding gaze behavior, in presenting participants the identical match situations in a reaction time task. The results showed that more experienced soccer players, in contrast to less experienced soccer players, possess a functionally organized cognitive representation of team-specific tactics in soccer. Moreover, the more experienced soccer players reacted faster in tactical decisions, because they needed less fixations of similar duration as compared to less experienced soccer players. Combined, these experiments offer evidence that a functionally organized memory structure leads to a reaction time and a perceptual advantage in tactical decision-making in soccer. The discussion emphasizes theoretical and applied implications of the current results of the study

Inquilinus limosus in Patients with Cystic Fibrosis, Germany

We identified Inquilinus limosus, a recently described α-proteobacterium, in sputum of 2 patients with cystic fibrosis whose respiratory tracts were persistently colonized for >9 months. We present data on the epidemiology, antimicrobial susceptibility, and molecular characteristics of I. limosus

Performance-based contracting in business markets

The aim of this Special Issue is to advance our understanding of performance-based contracting (PBC) in business markets. PBC has the potential for aligning incentives among buyers and sellers and fostering innovation. This paper critically reflects on extant research in order to develop a systematic knowledge map of PBC research. On that basis four major research gaps are identified and addressed, drawing out specific avenues for further PBC research. The knowledge map is also used to illustrate the focus and main arguments of the articles featuring in this Special Issue

Virtual 3D tumor marking-exact intraoperative coordinate mapping improve post-operative radiotherapy

The quality of the interdisciplinary interface in oncological treatment between surgery, pathology and radiotherapy is mainly dependent on reliable anatomical three-dimensional (3D) allocation of specimen and their context sensitive interpretation which defines further treatment protocols. Computer-assisted preoperative planning (CAPP) allows for outlining macroscopical tumor size and margins. A new technique facilitates the 3D virtual marking and mapping of frozen sections and resection margins or important surgical intraoperative information. These data could be stored in DICOM format (Digital Imaging and Communication in Medicine) in terms of augmented reality and transferred to communicate patient's specific tumor information (invasion to vessels and nerves, non-resectable tumor) to oncologists, radiotherapists and pathologists

Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae

O-Mannosylation is a vital protein modification conserved from fungi to humans. Yeast is a perfect model to study this post-translational modification, because in contrast to mammals O-mannosylation is the only type of O-glycosylation. In an essential step toward the full understanding of protein O-mannosylation we mapped the O-mannose glycoproteome in baker's yeast. Taking advantage of an O-glycan elongation deficient yeast strain to simplify sample complexity, we identified over 500 O-glycoproteins from all subcellular compartments for which over 2300 O-mannosylation sites were mapped by electron-transfer dissociation (ETD)-based MS/MS. In this study, we focus on the 293 O-glycoproteins (over 1900 glycosylation sites identified by ETD-MS/MS) that enter the secretory pathway and are targets of ER-localized protein O-mannosyltransferases. We find that O-mannosylation is not only a prominent modification of cell wall and plasma membrane proteins, but also of a large number of proteins from the secretory pathway with crucial functions in protein glycosylation, folding, quality control, and trafficking. The analysis of glycosylation sites revealed that O-mannosylation is favored in unstructured regions and β-strands. Furthermore, O-mannosylation is impeded in the proximity of N-glycosylation sites suggesting the interplay of these types of post-translational modifications. The detailed knowledge of the target proteins and their O-mannosylation sites opens for discovery of new roles of this essential modification in eukaryotes, and for a first glance on the evolution of different types of O-glycosylation from yeast to mammals

Particle Physics Implications for CoGeNT, DAMA, and Fermi

Recent results from the CoGeNT collaboration (as well as the annual modulation reported by DAMA/LIBRA) point toward dark matter with a light (5-10 GeV) mass and a relatively large elastic scattering cross section with nucleons (\sigma ~ 10^{-40} cm^2). In order to possess this cross section, the dark matter must communicate with the Standard Model through mediating particles with small masses and/or large couplings. In this Letter, we explore with a model independent approach the particle physics scenarios that could potentially accommodate these signals. We also discuss how such models could produce the gamma rays from the Galactic Center observed in the data of the Fermi Gamma Ray Space Telescope. We find multiple particle physics scenarios in which each of these signals can be accounted for, and in which the dark matter can be produced thermally in the early Universe with an abundance equal to the measured cosmological density.Comment: 4 pages, 2 figure

The kinetic dark-mixing in the light of CoGENT and XENON100

Several string or GUT constructions motivate the existence of a dark U(1)_D gauge boson which interacts with the Standard Model only through its kinetic mixing. We compute the dark matter abundance in such scenario and the constraints in the light of the recent data from CoGENT, CDMSII and XENON100. We show in particular that a region with relatively light WIMPS, M_{Z_D}< 40 GeV and a kinetic mixing 10^-4 < delta < 10^-3 is not yet excluded by the last experimental data and seems to give promising signals in a near future. We also compute the value of the kinetic mixing needed to explain the DAMA/CoGENT/CRESST excesses and find that for M_{Z_D}< 30 GeV, delta ~ 10^-3 is sufficient to fit with the data.Comment: 6 pages, 5figure

Gamma Ray Line Constraints on Effective Theories of Dark Matter

A monochromatic gamma ray line results when dark matter particles in the galactic halo annihilate to produce a two body final state which includes a photon. Such a signal is very distinctive from astrophysical backgrounds, and thus represents an incisive probe of theories of dark matter. We compare the recent null results of searches for gamma ray lines in the galactic center and other regions of the sky with the predictions of effective theories describing the interactions of dark matter particles with the Standard Model. We find that the null results of these searches provide constraints on the nature of dark matter interactions with ordinary matter which are complementary to constraints from other observables, and stronger than collider constraints in some cases.Comment: 20 pages, 9 figure

Abelian Hidden Sectors at a GeV

We discuss mechanisms for naturally generating GeV-scale hidden sectors in the context of weak-scale supersymmetry. Such low mass scales can arise when hidden sectors are more weakly coupled to supersymmetry breaking than the visible sector, as happens when supersymmetry breaking is communicated to the visible sector by gauge interactions under which the hidden sector is uncharged, or if the hidden sector is sequestered from gravity-mediated supersymmetry breaking. We study these mechanisms in detail in the context of gauge and gaugino mediation, and present specific models of Abelian GeV-scale hidden sectors. In particular, we discuss kinetic mixing of a U(1)_x gauge force with hypercharge, singlets or bi-fundamentals which couple to both sectors, and additional loop effects. Finally, we investigate the possible relevance of such sectors for dark matter phenomenology, as well as for low- and high-energy collider searches.Comment: 43 pages, no figures; v2: to match JHEP versio