Peroxisome Proliferator-Activated Receptor (PPAR): Balance for Survival in Parasitic Infections

Parasitic infections induce a magnitude of host responses. At the opposite ends of the spectrum are those that ensure the host's needs to eliminate the invaders and to minimize damage to its own tissues. This review analyzes how parasites would manipulate immunity by activating the immunosuppressive nuclear factor, peroxisome proliferator-activated receptors (PPARs) with type 2 cytokines and free fatty acids from arachidonic acid metabolism. PPARs limit the action of type 1 immunity, in which classically activated macrophages act through the production of proinflammatory signals, to spare the parasites. They also favor the development of alternately activated macrophages which control inflammation so the host would not be destroyed. Possibly, the nuclear factors hold a pivotal role in the establishment of chronic infection by delicately balancing the pro- and anti-inflammatory signaling mechanisms and their ligands may be used as combination therapeutics to limit host pathology

The formation of ultra-compact dwarf galaxies and nucleated dwarf galaxies

Ultra compact dwarf galaxies (UCDs) have similar properties as massive globular clusters or the nuclei of nucleated galaxies. Recent observations suggesting a high dark matter content and a steep spatial distribution within groups and clusters provide new clues as to their origins. We perform high-resolution N-body / smoothed particle hydrodynamics simulations designed to elucidate two possible formation mechanisms for these systems: the merging of globular clusters in the centre of a dark matter halo, or the massively stripped remnant of a nucleated galaxy. Both models produce density profiles as well as the half light radii that can fit the observational constraints. However, we show that the first scenario results to UCDs that are underluminous and contain no dark matter. This is because the sinking process ejects most of the dark matter particles from the halo centre. Stripped nuclei give a more promising explanation, especially if the nuclei form via the sinking of gas, funneled down inner galactic bars, since this process enhances the central dark matter content. Even when the entire disk is tidally stripped away, the nucleus stays intact and can remain dark matter dominated even after severe stripping. Total galaxy disruption beyond the nuclei only occurs on certain orbits and depends on the amount of dissipation during nuclei formation. By comparing the total disruption of CDM subhaloes in a cluster potential we demonstrate that this model also leads to the observed spatial distribution of UCDs which can be tested in more detail with larger data sets.Comment: 8 pages, 8 figures, final version accepted for publication in MNRA

Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis

The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone. Enthesis pathologies are common, and surgical repair of tendon to bone is plagued by high failure rates. At the root of these failures is a gap in knowledge of how the tendon enthesis is formed and maintained. We tested the hypothesis that the primary cilium is a hub for transducing biophysical and hedgehog (Hh) signals to regulate tendon enthesis formation and adaptation to loading. Primary cilia were necessary for enthesis development, and cilia assembly was coincident with Hh signaling and enthesis mineralization. Cilia responded inversely to loading; increased loading led to decreased cilia and decreased loading led to increased cilia. Enthesis responses to loading were dependent on Hh signaling through cilia. Results imply a role for tendon enthesis primary cilia as mechanical responders and Hh signal transducers, providing a therapeutic target for tendon enthesis pathologies

Temporal Migration Patterns Between Natal Locations of Ruby-Throated Hummingbirds (\u3ci\u3eArchilochus colubris\u3c/i\u3e) and Their Gulf Coast Stopover Site

Background Autumn latitudinal migrations generally exhibit one of two different temporal migration patterns: type 1 where southern populations migrate south before northern populations, or type 2 where northern populations overtake southern populations en route. The ruby-throated hummingbird (Archilochus colubris) is a species with an expansive breeding range, which allows opportunities to examine variation in the timing of migration. Our objective was to determine a relationship between natal origin of ruby-throated hummingbirds and arrival at a Gulf coast stopover site; and if so, what factors, such as differences in body size across the range as well as the cost of migration, might drive such a pattern. To carry out our objectives, we captured hummingbirds at a coastal stopover site during autumn migration, at which time we collected feathers from juveniles for analysis of hydrogen stable isotopes. Using the hydrogen stable isotope gradient of precipitation across North America and published hydrogen isotope values of feathers from populations of breeding ruby-throated hummingbirds, we assigned migrants to probable natal latitudes. Results Our results confirm that individuals from across the range (30–50° N) stopover along the Gulf of Mexico and there is a positive relationship between arrival day and latitude, suggesting a type 1 migration pattern. We also found no relationship between fuel load (proxy for migration cost) or fat-free body mass (proxy for body size) and natal latitude. Conclusions Our results, coupled with previous work on the spatial migration patterns of hummingbirds, show a type 1 chain migration pattern. While the mechanisms we tested do not seem to influence the evolution of migratory patterns, other factors such as resource availability may play a prominent role in the evolution of this migration system

The origin of polar ring galaxies: evidence for galaxy formation by cold accretion

Polar ring galaxies are flattened stellar systems with an extended ring of gas and stars rotating in a plane almost perpendicular to the central galaxy. We show that their formation can occur naturally in a hierarchical universe where most low mass galaxies are assembled through the accretion of cold gas infalling along megaparsec scale filamentary structures. Within a large cosmological hydrodynamical simulation we find a system that closely resembles the classic polar ring galaxy NGC 4650A. How galaxies acquire their gas is a major uncertainty in models of galaxy formation and recent theoretical work has argued that cold accretion plays a major role. This idea is supported by our numerical simulations and the fact that polar ring galaxies are typically low mass systems.Comment: 4 pages, 5 figures, stability of the ring discussed, minor changes to match the accepted version by ApJL. A preprint with high-resolution figures is available at http://krone.physik.unizh.ch/~andrea/PolarRing/PolarRing.p

The infrared imaging spectrograph (IRIS) for TMT: the science case

The InfraRed Imaging Spectrograph (IRIS) is a first-light instrument being designed for the Thirty Meter Telescope (TMT). IRIS is a combination of an imager that will cover a 16.4" field of view at the diffraction limit of TMT (4 mas sampling), and an integral field unit spectrograph that will sample objects at 4-50 mas scales. IRIS will open up new areas of observational parameter space, allowing major progress in diverse fields of astronomy. We present the science case and resulting requirements for the performance of IRIS. Ultimately, the spectrograph will enable very well-resolved and sensitive studies of the kinematics and internal chemical abundances of high-redshift galaxies, shedding light on many scenarios for the evolution of galaxies at early times. With unprecedented imaging and spectroscopy of exoplanets, IRIS will allow detailed exploration of a range of planetary systems that are inaccessible with current technology. By revealing details about resolved stellar populations in nearby galaxies, it will directly probe the formation of systems like our own Milky Way. Because it will be possible to directly characterize the stellar initial mass function in many environments and in galaxies outside of the the Milky Way, IRIS will enable a greater understanding of whether stars form differently in diverse conditions. IRIS will reveal detailed kinematics in the centers of low-mass galaxies, allowing a test of black hole formation scenarios. Finally, it will revolutionize the characterization of reionization and the first galaxies to form in the universe.Comment: to appear in Proc. SPIE 773

Marine mammal necropsy : an introductory guide for stranding responders and field biologists

This necropsy manual is designed to establish a base level of profiency in marine mammal necropsy techniques. It is written for stranding network members who do not have a formal pathobiological training and have limited knowledge of anatomy. Anatomical and pathological jargon has been kept to a minimum. This manual is divided into six sections: preliminary data, sample management, pinniped, small ceetacean, large whale (at sea and on the beach), and multiple appendices (A-H). A well-illustrated, carefully written gross necropsy report is essential to an adequate diagnostic investigation. Gross reports with significant detail and description tend to engender useful histopathological findings. A sample blank gross necropsy report and guidelines in writing a report can be found in Appendices A & B. Overall, this guide aims to lead the enquiring mind through the necessary steps to produce such reports. While this manual focuses on process and interpretation, it is important to understand that the gross necropsy is primarily about making detailed, descriptive observations without bias as to possible etiology. The necropsy should establish a list of differential diagnoses and the sampling be directed by an attempt to discriminate between them.Funding was provided by the National Oceanic and Atmospheric Administration under Cooperative Grant No. NA05NMF4391165

Construction of Papaya Male and Female BAC Libraries and Application in Physical Mapping of the Sex Chromosomes

Papaya is a major fruit crop in the tropics and has recently evolved sex chromosomes. Towards sequencing the papaya sex chromosomes, two bacterial artificial chromosome (BAC) libraries were constructed from papaya male and female genomic DNA. The female BAC library was constructed using restriction enzyme BstY I and consists of 36,864 clones with an average insert size of 104 kb, providing 10.3x genome equivalents. The male BAC library was constructed using restriction enzyme EcoR I and consists of 55,296 clones with an average insert size of 101 kb, providing 15.0x genome equivalents. The male BAC library was used in constructing the physical map of the male-specific region of the male Y chromosome (MSY) and in filling gaps and extending the physical map of the hermaphrodite-specific region of the Yh chromosome (HSY) and the X chromosome physical map. The female BAC library was used to extend the X physical map gap. The MSY, HSY, and X physical maps offer a unique opportunity to study chromosomal rearrangements, Y chromosome degeneration, and dosage compensation of the papaya nascent sex chromosomes

Modular Invariant Partition Functions in the Quantum Hall Effect

We study the partition function for the low-energy edge excitations of the incompressible electron fluid. On an annular geometry, these excitations have opposite chiralities on the two edges; thus, the partition function takes the standard form of rational conformal field theories. In particular, it is invariant under modular transformations of the toroidal geometry made by the angular variable and the compact Euclidean time. The Jain series of plateaus have been described by two types of edge theories: the minimal models of the W-infinity algebra of quantum area-preserving diffeomorphisms, and their non-minimal version, the theories with U(1)xSU(m) affine algebra. We find modular invariant partition functions for the latter models. Moreover, we relate the Wen topological order to the modular transformations and the Verlinde fusion algebra. We find new, non-diagonal modular invariants which describe edge theories with extended symmetry algebra; their Hall conductivities match the experimental values beyond the Jain series.Comment: Latex, 38 pages, 1 table (one minor error has been corrected