46,664 research outputs found

    Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

    Get PDF
    Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism

    Is Alice burning or fuzzing?

    Full text link
    Recently, Almheiri, Marolf, Polchinski and Sully (AMPS) have suggested a Gedankenexperiment to test black hole complementarity. They claim that the postulates of black hole complementarity are mutually inconsistent and choose to give up the "absence of drama" for an infalling observer. According to them the black hole is shielded by a firewall no later than Page time. This has generated some controversy. We find that an interesting picture emerges when we take into account objections from the advocates of fuzzballs. We reformulate AMPS' Gedankenexperiment in the decoherence picture of quantum mechanics and find that low energy wave packets interact with the radiation quanta rather violently while high energy wave packets do not. This is consistent with Mathur's recent proposal of fuzzball complementarity for high energy quanta falling into fuzzballs.Comment: 14 pages, 6 figures; v3: References added, discussions of some parts changed substantially, conclusions unaltere

    W' signatures with odd Higgs particles

    Full text link
    We point out that W' bosons may decay predominantly into Higgs particles associated with their broken gauge symmetry. We demonstrate this in a renormalizable model where the W' and W couplings to fermions differ only by an overall normalization. This "meta-sequential" W' boson decays into a scalar pair, with the charged one subsequently decaying into a W boson and a neutral scalar. These scalars are odd under a parity of the Higgs sector, which consists of a complex bidoublet and a doublet. The W' and Z' bosons have the same mass and branching fractions into scalars, and may show up at the LHC in final states involving one or two electroweak bosons and missing transverse energy.Comment: 24 page

    Solving the More Difficult Aspects of Electric Motor Thermal Analysis in Small and Medium Size Industrial Induction Motors

    Get PDF
    With the ever-increasing pressure on electric motor manufacturers to develop smaller and more efficient electric motors, there is a need for more thermal analysis in parallel with the traditional electromagnetic design. Attention to the thermal design can be rewarded by major improvements in the overall performance. Technical papers published to date highlight a number of thermal design issues that are difficult to analyze. This paper reviews some of these issues and gives advice on how to deal with them when developing algorithms for inclusion in design software
    corecore