3 research outputs found
Multidentate Block-Copolymer-Stabilized Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Enhanced Colloidal Stability for Magnetic Resonance Imaging
Ultrasmall superparamagnetic iron
oxide nanoparticles (USPIOs)
with diameters <5 nm hold great promise as <i>T</i><sub>1</sub>-positive contrast agents for in vivo magnetic resonance imaging.
However, control of the surface chemistry of USPIOs to ensure individual
colloidal USPIOs with a ligand monolayer and to impart biocompatibility
and enhanced colloidal stability is essential for successful clinical
applications. Herein, an effective and versatile strategy enabling
the development of aqueous colloidal USPIOs stabilized with well-defined
multidentate block copolymers (MDBCs) is reported. The multifunctional
MDBCs are designed to consist of an anchoring block possessing pendant
carboxylates as multidentate anchoring groups strongly bound to USPIO
surfaces and a hydrophilic block having pendant hydrophilic oligo(ethylene
oxide) chains to confer water dispersibility and biocompatibility.
The surface of USPIOs is saturated with multiple anchoring groups
of MDBCs, thus exhibiting excellent long-term colloidal stability
as well as enhanced colloidal stability at biologically relevant electrolyte,
pH, and temperature conditions. Furthermore, relaxometric properties
as well as in vitro and in vivo MR imaging results demonstrate that
the MDBC-stabilized USPIO colloids hold great potential as an effective <i>T</i><sub>1</sub> contrast agent
Histogram metrics of DTI-derived indices in control subjects and SCA2 patients.
<p>Median (interquartile range) data are reported. MD/AD/RD median and peak location are expressed in ×10<sup>−3</sup> mm<sup>2</sup>/s, while FA/MO median and peak location are unitless.</p
Processing pipeline for T<sub>1</sub>-weighted and diffusion-weighted images of a single subject.
<p>Processing pipeline for T<sub>1</sub>-weighted and diffusion-weighted images of a single subject.</p