La política de gestión de documentos electrónicos, otra vuelta de tuerca

Es reflexiona sobre la gestió dels documents electrònics en el context universitari espanyol de cooperació i es resumeix l'experiència de l'Àrea de Tecnologia i Comunicacions i l'Arxiu de la Universitat de Castilla-La Mancha en el desenvolupa-ment de la política de gestió documental institucional en els últims anys.This paper reflects on electronics records management in the Spanish university context and the recent experience of the IT Department and the Archives of University of Castilla-La Mancha developing a corporative records management policy.Se reflexiona sobre la gestión de los documentos electrónicos en el contexto universitario español de cooperación y se resume la experiencia del Área de Tecnología y Comunicaciones y el Archivo de la Universidad de Castilla-La Mancha en el desarrollo de la política de gestión documental institucional en los últimos años

“EVALUACIÓN DE LA SENSIBILIDAD Y ESPECIFICIDAD DE LA PROTEÍNA C REACTIVA, VELOCIDAD DE SEDIMENTACIÓN GLOBULAR Y EOSINOPENIA COMO MARCADORES DE INFECCIÓN EN EL SERVICIO DE MEDICINA INTERNA”

Evaluar la sensibilidad y especificidad diagnóstica de la Proteína C Reactiva, la Velocidad de Sedimentación Globular y la Eosinopenia como marcadores para detección de un proceso infeccioso en pacientes que ingresan al Servicio de Medicina Interna

Modelo computacional para la formación de clases de equivalencia

A computational model of neuronal net closely related with the formation of equivalence classes is developed. First the formal pattern of the neuronal net is presented and then its operation and its direct relationship with the phenomenon of the formation of the equivalence classes and with the derived relationships are explained. Later on, the validation of the pattern is described carrying out several simulations allowing verification of the pattern so it is able to generate relationships not explicitly trained, these results being adjusted to the basic results of this investigation line. These simulations were carried out using a training of classic conditioning and a test phase by means of conditional discriminations

Problemas antiplanos de mecánica de la fractura en materiales anisótropos

XV Congreso nacional de Ingeniería Mecánica, celebrado en Cádiz en 2002Se presenta la formulación mixta del Método de los Elementos de Contorno (MEC) para problemas de mecánica de fractura antiplanos en medios anisótropos. Se implementan las ecuaciones integrales (El) en desplazamientos y en tracciones. Las integrales hipersingulares asociadas a la El en tracciones se evalúan mediante un cambio de variable que permite su descomposición en integrales singulares con solución analítica conocida e integrales regulares de fácil integración numérica. Se consideran las soluciones fundamentales para plano completo y para semiplano.Ministerio de Ciencia y Tecnología DPI2000-12 l 7-C02-0

Effects of different error corrections on conditional discriminations acquisition

Se expuso a adultos a un procedimiento de discriminación condicional encadenada o uno con emparejamiento, con imágenes o nombres de pintores, sus nacionalidades y sus obras como estímulos muestra y de comparación. Después de las pruebas preliminares, se condujo el entrenamiento con las respuestas correctas seguidas por una consecuencia positiva y las incorrectas por una de cinco posibles correcciones por los errores. Estas podían ser: continuar con el siguiente ensayo (sin corrección), reiniciar el ensayo con la presentación señalada o no del estímulo muestra, reiniciar el ensayo en presencia del estímulo de comparación o una consecuencia de castigo positivo. Se asignó a seis participantes a cada una de las cinco condiciones de corrección durante 80 ensayos correctos o totales, dependiendo del tipo de corrección. Posteriormente, se condujeron las pruebas de las relaciones derivadas de reflexividad, simetría, transitividad y equivalencia. En general, hubo pocos aciertos en la condición de imágenes sin corrección. La ejecución fue mejor en el procedimiento de discriminación condicional con emparejamiento que en el procedimiento encadenado. Se concluyó que corregir los errores, así como los procedimientos de discriminación condicional con emparejamiento facilitan la adquisición de la discriminación condicional.Adults were exposed to a chained or a paired conditional discrimination procedure, with images or names of painters, their countries of origin, and their paintings as sample or comparison stimuli. After preliminary tests, training was conducted in which correct responses were followed by a positive outcome and incorrect ones by one out of five possible corrections. Corrections could be to continue to the next trial (no correction), to restart the trial with the signaled or not-signaled presentation of the sample stimulus, to restart the trial in the presence of the comparison stimuli, or a consequence of positive punishment. Six participants were assigned to each correction condition for 80 trials -correct or total trials, depending on the type of correction. Afterwards, derived-relation tests of reflexivity, symmetry, transitivity and equivalence were conducted. In general, participants had fewer correct esponses on the condition using images and no correction. Performance was better in the paired conditional discrimination procedure than in the chained procedure. It was concluded that correcting errors and using paired conditional discrimination tasks, facilitated the acquisition of conditional discriminations

An Extensive Validation of a SIR Epidemic Model to Study the Propagation of Jamming Attacks against IoT Wireless Networks.

This paper describes the utilization of an epidemic approach to study the propagation of jamming attacks, which can affect to different communication layers of all nodes in a variety of Internet of Things (IoT) wireless networks, regardless of the complexity and computing power of the devices. The jamming term considers both the more classical approach of interfering signals focusing on the physical level of the systems, and the cybersecurity approach that includes the attacks generated in upper layers like Medium Access Control (MAC), producing the same effect on the communication channel. In order to study the accuracy of the proposed epidemic model to estimate the propagation of jamming attacks, this paper uses the results of public simulations and experiments. It is of special interest the data obtained from experiments based on protocols such as Multi-Parent Hierarchical Protocol (MPH), Ad-hoc On-demand Distance Vector (AODV), and Dynamic Source Routing (DSR), working over the IEEE 802.15.4 standard. Then, using the formulation of the deterministic epidemiological model Susceptible–Infected–Recovered (SIR), together the abovementioned simulation, it has been seen that the proposed epidemic model could be used to estimate in that kind of IoT networks, the impact of the jamming attack in terms of attack severity and attack persistenceThis research has been partially supported by Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER, UE) under projects TIN2017-84844-C2-1-R and PGC2018-098813-B-C32

Comparison of error correction trials in conditional discriminations acquisition

El objetivo del estudio fue comparar diferentes métodos de corrección de errores en una tarea de discriminación condicional, en participantes de diferentes grupos de edad (7-8, 10-11, 15-16 y 19-20 años), para determinar el tipo de corrección más eficaz en el aprendizaje. Se diseñó un experimento en el que se usó una tarea de igualación a la muestra de primer orden. En la tarea, cuatro letras latinas funcionaron como estímulo muestra, y cuatro símbolos chinos funcionaron como estímulos de comparación. En caso de error en la respuesta de los participantes, se utilizó uno de los tipos de corrección contemplados en esta investigación: castigo positivo, seguimiento de regla, corrección llevada a la muestra y corrección llevada a las comparaciones. Además, se contó con un grupo control, que no recibió ninguna corrección ante los errores. Se contabilizó el número de ensayos necesarios para aprender la tarea. Los resultados mostraron diferencias entre los grupos que recibieron corrección con respecto al que no, siendo la ejecución peor en este último. Además, se encontró que la corrección con castigo positivo ralentizó el aprendizaje de la tarea. Los resultados resaltan la importancia del uso de corrección diferente del castigo positivo en las tareas de discriminación condicional.The aim of the study was to compare different methods of error correction in a conditional discrimination task presented to subjects of different age groups (7-8, 10-11, 15-16 and 19-20 years) to determine the most effective type of learning correction by this method. A first-order matching-to-sample task was used. In this task four Latin letters functioned as sample stimuli, and four Chinese symbols functioned as comparison stimuli. Whenever an error occurred, one of four types of correction was used: positive punishment, rule following, correction applied to sample and correction applied to comparisons. In addition, participants in a control group did not receive any correction following errors. The number of trials required for each participant to learn the task was analyzed. Differences in the execution between the groups that received different correction procedures revealed that performance was worse in the group that did not receive correction. Additionally, the number of trials required to learn the task was higher with positive punishment. The results emphasize the importance of use of correction procedures in conditional discrimination tasks

<i>In Situ </i>Studies of Arylboronic Acids/Esters and R₃SiCF₃ Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion–Ate Interface

[Image: see text] Reagent instability reduces the efficiency of chemical processes, and while much effort is devoted to reaction optimization, less attention is paid to the mechanistic causes of reagent decomposition. Indeed, the response is often to simply use an excess of the reagent. Two reaction classes with ubiquitous examples of this are the Suzuki–Miyaura cross-coupling of boronic acids/esters and the transfer of CF(3) or CF(2) from the Ruppert–Prakash reagent, TMSCF(3). This Account describes some of the overarching features of our mechanistic investigations into their decomposition. In the first section we summarize how specific examples of (hetero)arylboronic acids can decompose via aqueous protodeboronation processes: Ar–B(OH)(2) + H(2)O → ArH + B(OH)(3). Key to the analysis was the development of a kinetic model in which pH controls boron speciation and heterocycle protonation states. This method revealed six different protodeboronation pathways, including self-catalysis when the pH is close to the pK(a) of the boronic acid, and protodeboronation via a transient aryl anionoid pathway for highly electron-deficient arenes. The degree of “protection” of boronic acids by diol-esterification is shown to be very dependent on the diol identity, with six-membered ring esters resulting in faster protodeboronation than the parent boronic acid. In the second section of the Account we describe (19)F NMR spectroscopic analysis of the kinetics of the reaction of TMSCF(3) with ketones, fluoroarenes, and alkenes. Processes initiated by substoichiometric “TBAT” ([Ph(3)SiF(2)][Bu(4)N]) involve anionic chain reactions in which low concentrations of [CF(3)](−) are rapidly and reversibly liberated from a siliconate reservoir, [TMS(CF(3))(2)][Bu(4)N]. Increased TMSCF(3) concentrations reduce the [CF(3)](−) concentration and thus inhibit the rates of CF(3) transfer. Computation and kinetics reveal that the TMSCF(3) intermolecularly abstracts fluoride from [CF(3)](−) to generate the CF(2), in what would otherwise be an endergonic α-fluoride elimination. Starting from [CF(3)](−) and CF(2), a cascade involving perfluoroalkene homologation results in the generation of a hindered perfluorocarbanion, [C(11)F(23)](−), and inhibition. The generation of CF(2) from TMSCF(3) is much more efficiently mediated by NaI, and in contrast to TBAT, the process undergoes autoacceleration. The process involves NaI-mediated α-fluoride elimination from [CF(3)][Na] to generate CF(2) and a [NaI·NaF] chain carrier. Chain-branching, by [(CF(2))(3)I][Na] generated in situ (CF(2) + TFE + NaI), causes autoacceleration. Alkenes that efficiently capture CF(2) attenuate the chain-branching, suppress autoacceleration, and lead to less rapid difluorocyclopropanation. The Account also highlights how a collaborative approach to experiment and computation enables mechanistic insight for control of processes

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair

Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility, as it participates in different DNA repair and damage tolerance pathways in which gap-filling DNA synthesis is required. In this work we show that human Polλ is conjugated with Small Ubiquitin-like MOdifier (SUMO) proteins both in vitro and in vivo, with Lys27 being the main target of this covalent modification. Polλ SUMOylation takes place in the nuclear pore complex and is mediated by the E3 ligase RanBP2. This post-translational modification promotes Polλ entry into the nucleus, which is required for its recruitment to DNA lesions and stimulated by DNA damage induction. Our work represents an advance in the knowledge of molecular pathways that regulate cellular localization of human Polλ, which are essential to be able to perform its functions during repair of nuclear DNA, and that might constitute an important point for the modulation of its activity in human cells

Non uniform embedding based on relevance analysis with reduced computational complexity: application to the detection of pathologies from biosignal recordings

Nonlinear analysis tools for studying and characterizing the dynamics of physiological signals have gained popularity, mainly because tracking sudden alterations of the inherent complexity of biological processes might be an indicator of altered physiological states. Typically, in order to perform an analysis with such tools, the physiological variables that describe the biological process under study are used to reconstruct the underlying dynamics of the biological processes. For that goal, a procedure called time-delay or uniform embedding is usually employed. Nonetheless, there is evidence of its inability for dealing with non-stationary signals, as those recorded from many physiological processes. To handle with such a drawback, this paper evaluates the utility of non-conventional time series reconstruction procedures based on non uniform embedding, applying them to automatic pattern recognition tasks. The paper compares a state of the art non uniform approach with a novel scheme which fuses embedding and feature selection at once, searching for better reconstructions of the dynamics of the system. Moreover, results are also compared with two classic uniform embedding techniques. Thus, the goal is comparing uniform and non uniform reconstruction techniques, including the one proposed in this work, for pattern recognition in biomedical signal processing tasks. Once the state space is reconstructed, the scheme followed characterizes with three classic nonlinear dynamic features (Largest Lyapunov Exponent, Correlation Dimension and Recurrence Period Density Entropy), while classification is carried out by means of a simple k-nn classifier. In order to test its generalization capabilities, the approach was tested with three different physiological databases (Speech Pathologies, Epilepsy and Heart Murmurs). In terms of the accuracy obtained to automatically detect the presence of pathologies, and for the three types of biosignals analyzed, the non uniform techniques used in this work lightly outperformed the results obtained using the uniform methods, suggesting their usefulness to characterize non-stationary biomedical signals in pattern recognition applications. On the other hand, in view of the results obtained and its low computational load, the proposed technique suggests its applicability for the applications under study