General influence of biphasic calcium phosphate on osteoporotic bone density

Funding Information: The study was supported by the National Research Programme No. 2014.10-4/VPP-3/21 “Multifunctional Components and composites, photonics and nanotechnology”. Project No. 4 “Nanocomponents and nanotechnologies for medical applications”. Publisher Copyright: © 2019 Vladislavs Ananjevs et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.publishersversionPeer reviewe

Calcium Phosphate Bioceramic Material Local Influence on the Bone Biomechanical Properties at Rabbits with Experimental Osteoporosis

Biomechanical characteristicsof the rabbit cartilagecomponentfrom the femurwereinvestigated.The controlosteoporosishad beenactivatedby ovariectomy alongside theinjections of methylprednisolone. During the experiment defects in the femur’sgreater trochanter zonewas created andafterwardsfilled withthefragmentsof a hydroxyapatite as well astricalcium phosphate(HAP/TCP 70/30) or HAP/TCP 70/30mixedwith five percentstrontium. Threemonths lateranimals were euthanazed, squared samples werecut out from the femur’sbody andlatertested on a bend. The results ofthe research revealedthat the femurs becomemorestringentafter filling offdefects in the greater trochanter zonewith HAP/TCP 70/30or HAP/TCP 70/30mixed with fivepercentstrontium. The ultimate painfor the cartilagecomponentin the controlgroupswas less, than in thetest group.The flexure modulus of flexibilityof a cartilagecomponentin the test groupwas statistically reliable less, than the value of the flexure modulus of flexibilityof the cartilagecomponentin the controlgroups. Therefore, local usage ofcalcium –phosphatic bioceramic componentoverthe greater trochanter partincreasesbiomechanical characteristicsof the cartilagecomponentin the femurof animals.Peer reviewe