Deep Neural Networks Generalization and Fine-Tuning for 12-lead ECG Classification

Numerous studies are aimed at diagnosing heart diseases based on 12-lead electrocardiographic (ECG) records using deep learning methods. These studies usually use specific datasets that differ in size and parameters, such as patient metadata, number of doctors annotating ECGs, types of devices for ECG recording, data preprocessing techniques, etc. It is well-known that high-quality deep neural networks trained on one ECG dataset do not necessarily perform well on another dataset or clinical settings. In this paper, we propose a methodology to improve the quality of heart disease prediction regardless of the dataset by training neural networks on a variety of datasets with further fine-tuning for the specific dataset. To show its applicability, we train different neural networks on a large private dataset TIS containing various ECG records from multiple hospitals and on a relatively small public dataset PTB-XL. We demonstrate that training the networks on a large dataset and fine-tuning it on a small dataset from another source outperforms the networks trained only on one small dataset. We also show how the ability of a deep neural networks to generalize allows to improve classification quality of more diseases

Artificial Intelligence Assists in the Detection of Blood Vessels in Whole Slide Images: Practical Benefits for Oncological Pathology

The analysis of the microvasculature and the assessment of angiogenesis have significant prognostic value in various diseases, including cancer. The search for invasion into the blood and lymphatic vessels and the assessment of angiogenesis are important aspects of oncological diagnosis. These features determine the prognosis and aggressiveness of the tumor. Traditional manual evaluation methods are time consuming and subject to inter-observer variability. Blood vessel detection is a perfect task for artificial intelligence, which is capable of rapid analyzing thousands of tissue structures in whole slide images. The development of computer vision solutions requires the segmentation of tissue regions, the extraction of features and the training of machine learning models. In this review, we focus on the methodologies employed by researchers to identify blood vessels and vascular invasion across a range of tumor localizations, including breast, lung, colon, brain, renal, pancreatic, gastric and oral cavity cancers. Contemporary models herald a new era of computational pathology in morphological diagnostics