Perfectionism as Predictor of Psychological Wellbeing among College Students

India is a collectivistic society that places considerable amount of importance on its members to strive for the best as every action desire accomplishment and failure has social connotations for family and other close members of society There are social pressures to achieve and to be perfect This has a direct implication on the wellbeing of an individual especially college students since they are in the transition phase wherein they are looking for meaning in life in terms of right career choices and making their parents proud The present study explored perfectionism and psychological wellbeing among college students and their interrelationship A total of 281 college students Males 174 Females 107 in the age range of 18-24 years participated in the study They were administered Multidimensional Perfectionism Scale and Ryff s Scale of Psychological Wellbeing Results revealed that all the three dimensions of perfectionism show significant relationship with all the six dimensions of psychological wellbeing Perfectionism both self oriented and socially prescribed accounted for a large variance in many dimensions of psychological wellbeing Others Oriented Perfectionism did not come out to be contributing to psychological wellbeing Perfectionism emerged to be one of the major contributors to psychological health and wellbein

Spirituality Scale: Development and Validation

The genesis of spirituality is challenging due to a wide variety of perspectives and assumptions underlying spirituality research. Spirituality is still an emerging concept in the developing countries such as India, although rich culture has enriched in the past. Confining to various definitions of spirituality, the study attempts to evolve a health oriented spirituality scale in an Indian context. With exploration of literature and expert reviews, various attributes of spirituality scale were initiated with a pool of 120 items. These items were subjected to experts’ opinion and were reduced to 77. The version I scale was then administered on a sample of 254 participants. After initial factor analyses, the scale was again administered on a sample of 104 participants. Principal component analyses were employed and 56 items were retained covering five factors for final version of Spirituality Scale. The reliability was 0.640 and validity was 0.491

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Sickle cell disease causes severe pain. We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS). Paw withdrawal threshold and withdrawal latency (to mechanical and thermal stimuli, respectively) and grip force were lower in homozygous and hemizygous Berkley mice (BERK and hBERK1, respectively) compared with control mice expressing human hemoglobin A (HbA-BERK), indicating deep/musculoskeletal and cutaneous hyperalgesia. Peripheral nerves and blood vessels were structurally altered in BERK and hBERK1 skin, with decreased expression of μ opioid receptor and increased calcitonin gene-related peptide and substance P immunoreactivity. Activators of neuropathic and inflammatory pain (p38 mitogen-activated protein kinase, STAT3, and mitogen-activated protein kinase/extracellular signal-regulated kinase) showed increased phosphorylation, with accompanying increase in COX-2, interleukin-6, and Toll-like receptor 4 in the spinal cord of hBERK1 compared with HbA-BERK. These neurochemical changes in the periphery and spinal cord may contribute to hyperalgesia in mice expressing HbS. In BERK and hBERK1, hyperalgesia was markedly attenuated by morphine and cannabinoid receptor agonist CP 55940. We show that mice expressing HbS exhibit characteristics of pain observed in sickle cell disease patients, and neurochemical changes suggestive of nociceptor and glial activation. Importantly, cannabinoids attenuate pain in mice expressing HbS