Pemberian Citicoline Pada Tikus Cedera Saraf Mentalis: Ekspresi Gen SIRT1 Ganglion Trigeminal: the Administration of Citicoline on Rat Model with Mental Nerve Crush Injury: Gene Expression of Trigeminal Ganglion SIRT1

Cedera saraf perifer menyebabkan jumlah neuron menurun di ganglion sensorik, sehingga regenerasinya tidak baik. Pemberian Citicoline telah dilaporkan dapat memperbaiki kondisi fungsi motorik dan mencegah nyeri neuropati pada model tikus cedera saraf perifer. Pada ganglion sensorik, peningkatan regenerasi terkait dengan SIRT1 yang mendorong kelangsungan hidup neuron. Penelitian ini bertujuam untuk menguji hipotesis bahwa pemberian citicoline meningkatkan ekspresi gen SIRT1 fase akut pada model tikus cedera saraf mentalis. Setelah dianestesi, saraf mentalis kanan dijepit dengan klem tanpa gerigi selama 30 detik. Tikus-tikus dibagi menjadi 3 kelompok, kelompok operasi sham, kelompok cedera dan kelompok citicoline. Citicoline diberikan secara i.p. 50 mg/kg BB/hari selama 7 hari. Tikus dinekropsi pada hari ke-1, 3 dan 7 setelah cedera. Pada hari ke-1,3,7 (3 tikus per kelompok), ganglion trigeminal kanan dipotong dan diekstraksi RNA, reverse transcriptase PCR dan qPCR untuk melihat ekspresi gen SIRT1. Hasil penelitian menunjukkan peningkatan ekspresi SIRT1 hari ke-7 setelah cedera saraf mentalis tikus yang diberikan terapi citicoline i.p. Sebagai kesimpulan, pemberian citicolin segera setelah cedera saraf mentalis meningkatkan ekspresi SIRT1 pada hari ke-7

Kajian Angin Ribut Berdasarkan Unsur Iklim dan Aspek Lahan di Wilayah Bandung

Tujuan dari penelitian ini yaitu mengetahui pola sebaran spasial dan temporal kejadian angin ribut di wilayah Bandung, serta mengetahui hubungan spasial antara kejadian angin ribut dengan faktor kondisi iklim dan lahan pada daerah terdampak kejadian angin ribut di wilayah Bandung.Morfologi wilayah Bandung memiliki morfologi dataran tinggi yang dikelilingi oleh deretan pegunungan dan perbukitan yang dapat mempengaruhi kondisi iklim wilayah Bandung. Data yang digunakan berupa data iklim dan lahan pada periode Juli 2012 – Juli 2013 yang meliputi data bulanan temperatur udara, tekanan udara, dan kelembaban udara, arah dan kecepatan angin harian, data kontur, serta tutupan lahan. Analisis dilakukan secara deskripsi, spasial, temporal, grafis, dan statistik. Analisis statistik diperoleh dari hasil overlay data yang dikonversi melalui klasifikasi, tabulasi silang digunakan untuk menentukan hubungan dari variabel pengaruh terhadap variabel terpengaruh.Hasil menunjukkan bahwa persebaran daerah terdampak angin ribut berada dekat dengan celah topografi yang terdapat di wilayah Bandung. Kejadian angin ribut lebih sering terjadi pada musim penghujan dengan total 78 kejadian. Kejadian angin ribut sering terjadi pada daerah dengan kondisi temperatur udara antara 21 – 24 ºC dengan dominasi 100% dalam 7 bulan, tekanan udara antara 895 – 932 mbar dengan dominasi 100% dalam 6 bulan, kelembaban udara 80 – 87 % dengan dominasi 100% dalam 7 bulan, kemiringan lereng datar dengan dominasi tertinggi 22,27%, arah hadap lereng yang rata dengan dominasi tertinggi 16,3%, dan tutupan lahan yang umumnya berupa sawah dengan dominasi tertinggi 14,13%

Kajian Efisiensi Desain Sirkulasi pada Fungsi Bangunan Mall dan Hotel BTC

Bandung Trade Center ( BTC ) is a commercial building that has two functions of building a Mall and Hotel . The building stands on the same region without any barrier to reach the second function of the building , so that the second function of this building is very interesting to study the sustainability of the design efficiency of circulation . Studies of both commercial buildings function is to know and understand the form of circulation space , zone function space , circulation space design patterns and some aspects of the circulation of such convenience of distance and time as well as the achievement of the application of circulation elements ( signage ) are efficient at building Mall and Hotel BTC . The study was conducted through descriptive analysis , so that the two functions in one area of the building , effectively and efficiently in the distance and travel time can be realized by minimizing the application of a circulating bridge design and the use of circulation elements ( signage ) for comfort and ease of circulation

Pola Hubungan Negara Dan Civil Society

Tulisan ini dikembangkan dari hasil penelitian dengan tema sentral strategi penguatan civil society pada aras lokal Sumatra Barat dengan menitikberatkan pada proses adaptasi dan respon civil society terhadap kebijakan/regulasi yang diintrodusir pemerintah sebagai penyelenggara negara. Gerakan civil society yang menakjubkan juga pernah menyentakkan mata masyarakat Sumatra Barat, terutama, melalui sepak terjang tiga gerakan berikut: Forum Peduli Sumatra Barat (FPSB) yang berhasil menghantarkan 42 dari 43 anggota DPRD Sumatra Barat ke meja hijau untuk mempertanggungjawabkan ‘korupsi berjamaah\u27 yang dilakukan anggota dewan yang terhormat itu. Penelitian ini dibangun di atas paradigma post-positivisme dan pendekatan kulitatif. Temuan penelitian menunjukkan, kebijakan/regulasi yang bermuara pada terbukanya ruang publik dalam penerapan demokrasi, telah mendorong Perubahan dalam metode dan strategi perjuangan civil society di daerah Sumatra Barat. This paper was developed from research with the central theme strategy strengthening civil society at the local level of West Sumatra with emphasis on the process of adaptation and response of civil society on the policies / regulations introduced as the organizer of the state government. Civil society movements were amazing also been jerked the eyes of the people of West Sumatra, in particular, through the exploits of three following movements: Concern Forum West Sumatra (FPSB), which managed to deliver 42 of the 43 legislators of West Sumatra to court to account ‘corruption congregation\u27 conducted board members are honored. This study built on the paradigm of post-positivism and qualitative approach to research findings indicate, policy / regulation which led to the opening of public space in the application of democracy, has prompted changes in the methods and strategies of struggle of civil society in the area of West Sumatra

Aplikasi Shrinking Core Model pada Sintesis Hidroksiapatit dari Kulit Kerang Darah (Anadara Granosa) dengan Menggunakan Metode Hidrotermal Suhu Rendah

Hydroxyapatite (HA) is a ceramic material that can be used as bone and dental implants. Hydroxyapatite can be synthesized from the cockle shell (Anadara granosa). The purpose of this study was to determine the effect of time and stirring rate on the characteristics of HA using a low temperature hydrothermal method as well as decide of the kinetics model with the approach of shrinking core models. There are 3 models that are used, namely diffusion through the liquid film control, diffusion through the layer results (HA) control, and chemical reaction control. Research procedures initiated by the reaction of 36.9 g NH4H2PO4 dissolved in 600 mL of water were then added as much as 39.37 g CaO at stirring rate of 100 rpm, 200 rpm, 300 rpm and reaction time of 5 minutes to 150 minutes. The mixture was reacted at a temperature of 90˚C to form a paste. The paste was dried in an oven at 120˚C for 12 hours and calcined at a temperature of 900˚C for 1 hour. The results showed that the product formed is 95% fraction massa of HA. Kinetics model that describes the events of the synthesis of HA for belong to model 2, i.e diffusion through the layer results (HA) control with the smallest error percentage of 16.15 % with the formula

Analisis Konsumsi Masyarakat Indonesia Sebelum Dan Setelah Krisis Ekonomi

This study aims to determine and analyze how big the marginal propensity to consume (MPC) and the average propensity to consume (APC) the people of Indonesia before and after the economic crisis and to find out and analyze what factors are affecting the consumption of Indonesian society. The method used in this research is descriptive and quantitative methods. From the research : 1) the marginal propensity to consume (MPC) the people of Indonesia after the economic crisis has decreased and the average propensity to consume (APC) the people of Indonesia after the economic crisis have increased. 2) Before the economic crisis affecting consume of Indonesian society is the national income and deposit rates. After the economic crisis affecting consume of Indonesian society is the national income and inflation. And overall, both before and after the economic crisis affecting consume of Indonesian society is the national income and deposit rates

Tingkat Ketergantungan Fiskal Dan Hubungannya Dengan Pertumbuhan Ekonomi Di Kota Jambi

This research aims to calculate Fiscal Needs in Jambi City and analyze the level of dependence on Fiscal relations with the Economic Growth in Jambi and see how much the rate dependence of the Fiscal Jambi City to the Central Government. These results indicate that the Fiscal Needs in Jambi city has increased significantly each year, the average growth of 46.28 %. Local Government Fiscal Dependence level of Jambi City to the Central Government is very High, the average in the past 11 years (2000 s / d 2010) the proportion of PAD to the total of the local revenue obtained an average of 9.6% and the proportion of average fund balance of the total of local revenues obtained an average of 90.4%, The relationship between the level of fiscal dependence with the Economic Growth in Jambi is very low, amounting to only 0.068

Graphene Nanosheets (GNs) addition on the Palm Oil Fuel Ash (POFA) based geopolymer with KOH activator

Graphene Nanosheets (GNs) have been successfully added to the palm oil fuel ash (POFA) based geopolymer with KOH activator to improve the geopolymer compressive strength. The graphene was synthesized using turbulence assisted shear exfoliation (TASE) method and identified using Raman spectroscopy. The influence of concentrations and weight percent of graphene against the compressive strength, porosity, and morphological properties were investigated. The crystallinity phases of geopolymer and graphene were also identified using XRD. Raman spectroscopy revealed that graphene produced by TASE method had ≥ 3 layers (graphene nanosheets, GNs). Furthermore, Raman maping constructed by the intensity D band showed the graphene had different atomic arrangements at the edge (armchair and zigzag). The compressive strength and the porosity tests showed that increasing the concentration and the weight percent of graphene increased the compressive strength and reduced the porosity. The highest compressive strength and the lowest porosity (10.8 MPa and 5.92%, respectively) were exhibited by the geopolymer synthesized using 0.7 wt% graphene with concentrations of 30 mg/ml. The SEM micrographs indicated that the graphene reduced the porosity of geopolymers with a pores fulfilling mechanism due to of very small of graphene nanosheets size (~60 - ~80 nm)