ПРИНЦИПЫ МЕЖКУЛЬТУРНОЙ КООПЕРАЦИИ РОССИИ И КИТАЯ

This review is an attempt to systematically outline the main principles of cultural interaction between Russia and China. One of the most significant aspects is the cooperation of the states in the field of education, which is actual, in particular, for the Peoples’ Friendship Uneversity of Russia, within the walls of which intercultural communication programs between students of both countries are being implemented.В статье дается краткий обзор основных направлений культурного взаимодействия между Россией и Китаем. Один из наиболее значимых аспектов - сотрудничество государств в области образования, актуальное, в частности, для Российского университета дружбы народов, в стенах которого реализуются программы межкультурной коммуникации обеих стран

Restoration of Housing and Communal services of Leningrad from 1942-1944: the Temporal Experience of the Besieged City

In their article, the author analyzes a critical point for the Soviet culture of the 1940s. This study is based on published sources, including data from periodicals, and unpublished materials from the archives of Moscow and St. Petersburg. The purpose of it is to determine the features of the temporal characteristics of the restoration stages of Leningrad’s housing and communal services during the years of the siege. The research tools used including those investigating concrete-historical issues, problem-chronological methods, historical reconstruction, as well as linguo-culturological analysis. The identification and systematization of temporal concepts are implemented through three blocks (typological, structural, semiotic) in the paper, concepts which have contributed to the study of the relationship between material culture and the temporal dimensions of the era. There were two stages of the revival of Leningrad’s urban economy during the war years which should be singled out. The specific character of the first stage (January 1942 - January 1943) was the combination of restoration with continued emergency activities, and the second stage (January 1943 - January 1944), when the government began introducing, the restoration of housing and communal services, while taking into account the plans for the development of Leningrad in the post-war period. The temporal characteristics of the first period were colored by “siege time,” broad aspirations for the future largely marred due the establishment of unrealistic deadlines for the implementation of decisions and plans, as well as determination of restoration priorities in accordance with the seasonality of tasks. The second period was also characterized by acceleration in the pace of work carried out in the city due to a release of increased labor and funding, however, there was a discrepancy between real and assumed time in the perception of the Leningrad authorities, and understanding of time in terms of the realistic limits of under their control

Influence of pharmacogenetically determined treatment on parameters of peripheral hemodynamics in patients with arterial hypertension

Aim: To evaluate daily blood pressure monitoring (DBPM) data changes in patients with essential arterial hypertension (EAH) under the influence of pharmacogenetically determined treatment depending on genes polymorphisms of angiotensin-converting enzyme (ACE, I/D), angiotensin II fifirst type receptor (AGTR1, А1166С), endothelial NO-synthase (eNOS, T894G), peroxisome proliferators-activated receptor-γ2 (PPAR-γ2, Pro12Ala), β1-adrenergic receptor (ADRB1, Arg389Gly). Material and Methods: 249 patients with EAH І-ІІІ stages (48.2% – women, 51.8% – men, mean ages 50.5±10.4 years) and 50 practically healthy persons were observed. Alleles of polymorphic locus were assessed by polymerase chain reaction (PCR) based method. DBPM was performed according to standard protocol. Patients were split by genotypes and treatment type into 6 groups: 1st group: I-allele of ACE gene carriers (n=60) took Hydrochlorothiazide (HCTZ) and angiotensin II receptor blocker (ARB II); 2nd group: I/D-genotype carriers (n=34) took HCTZ+β1-adrenobloker (β1-АB); 3rd group: I/D-genotype carriers (n=50) took HCTZ+ACE-inhibitor (ACEI); 4th group: DD-genotype carriers (n=15) took calcium channels bloker (CCB)+ ARB II; 5th group: DD-genotype carriers (n=15) took CCB+β1-АB; 6th group: DD-genotype carriers (n=27) took CCB+ACEI. Treatment efficacy was analyzed according to European Guidelines (2007). Results: Pharmacogenetically determined treatment of EAH patients during 9-12 months caused daily, day, and night blood pressure (BP) decrease below the “threshold” level in 154 (76.6%) patients. That did not significantly differ from the frequency of “target” office BP achievement: 149 (74.1%). The number of patients with normal BP daily profile “dipper” increased reliably by 10.1% (р<0.001), with “non-dipper” and “night-peaker” patients amount diminishing (р<0.05). Longterm combined therapy caused achievement of “target” average daily BP24 (DBPM) depending on types of treatment combination: after HCTZ+ARB ІІ – in 55 (91.7%) patients; after HCTZ+β1-AB – in 25 (73.5%) persons; after HCTZ+ACEI – in 33 (66.0%) patients; after CCB+ARB II – in 11 (73.3%) persons, without a reliable difference between genotypes; after CCB+β1-AB – in 11 (73.3%) patients (easier in Ala-allele carriers of PPAR-γ2 gene, р=0.002); after CCB+ACEI – in 19 (70.4%) patients (easier in AlaAla-genotype carriers of PPAR-γ2 gene, р=0.007). Conclusions: Prescription of HCTZ+ARB II drugs combination is more effective in treatment of EAH І-allele carriers of ACE gene patients than HCTZ+β1-АB or HCTZ+ACEI – 91.7% vs 66.0 or 73.5%, accordingly (р<0.001); for DD-genotype carrier hypertensive patients the combination of CCB+ARB II and CCB+β1-АB is more effective than CCB+ACEI – 73.3% vs 70.4%, accordingly

Features of the hemostasis system state in patients with pulmonary tuberculosis detected by the method of low-frequency vibration piezoelectric hemocoagulography

Objective: to estimate the state of the hemostasis system in patients with tuberculosis by the method of LPHC. Methods: the state of the hemostasis system in patients with tuberculosis was evaluated with the aid of the analyzer of the blood rheological properties ARP - 01 “Mednord” as well as by the use of a standard complex of laboratory coagulation tests. The indices characterizing the initial stages of the blood coagulation, the intensity of thrombin formation and fibrin polymerization was evaluated by the LPHC method as well as the indices, which characterize the intensity of the clot retraction and fibrinolytic activity. Results: the comparative analysis of the state of the hemostasis system with the use of a standard coagulogram and LPHC express method in patients with tuberculosis revealed the presence of the processes of the moderate hyper-coagulation shift and suppression of fibrinolysis in them. Conclusion: the comparative estimation of the state of the hemostasis system in patients with tubercular infection with the aid of the method of low-frequency vibration piezoelectric hemocoagulography and standard coagulation tests revealed unidirectionality of the processes. The determination of changes in the components of the regulation of aggregation of the blood condition (RABC) system by the LPHC method allows to diagnose the development of complications in the blood coagulation system in patients with tuberculosis without manifestations of the corresponding clinical symptoms

Whole-genome experimental identification of insertion/deletion polymorphisms of interspersed repeats by a new general approach

A new experimental technique for genome-wide detection of integration sites of polymorphic retroelements (REs) is described. The technique allows one to reveal the absence of a retroelement in an individual genome provided that this retroelement is present in at least one of several other genomes under comparison. Since quite a number of genomes are compared simultaneously, the search for polymorphic REs insertions is very efficient. The technique includes two whole-genome selective PCR amplifications of sequences flanking REs: one for a particular genome and another one for a mixture of ten different genomes. A subsequent subtractive hybridization of the obtained amplicons with DNA of a particular genome as driver results in isolation of polymorphic insertions. The technique was successfully applied for identification of 41 new polymorphic human AluYa5/Ya8 insertions. Among them, 18 individual Alu elements first sequenced in this work were not found in the available human genome databases. This result suggests that significant part of polymorphic REs were not identified during genome sequencing and remain to be detected and characterized. The proposed method does not depend on preliminary knowledge of evolutionary history of retroelements and can be applied for identification of insertion/deletion polymorphic markers in genomes of different species

Linguistic Technologies of Discrediting on the Agenda of the English-Language Mass Media

В статье рассматриваются лингвистические технологии дискредитации на примере освещения событий, связанных с российским спортом, в авторитетных англоязычных средствах массовой информации.The article analyzes linguistic technologies of discrediting by the example of publications related to the Russian sports in quality English-language mass media. The research material comprises texts of print and electronic media and comments on them in the period 2014-2021

Клінічна значимість погіршення функції нирок у хворих з гострою декомпенсованою серцевою недостатністю в залежності від змін NGAL і вихідної функції нирок

Aim. To determine the value of the renal function worsening (RFW) depending on NGAL and initial renal dysfunction in so-called “wet and warm” patients with acute decompensated heart failure (ADHF).Materials and methods. The prospective study included 141 patients with ADHF 38–85 years old (mean age 66,4±2,2), successively admitted to cardiologic department of Olexandrivska clinical hospital in Kyiv during 2012–2014, 38 patients had RFW, 67 patients underwent the assessment of NGAL in blood serum using enzymatic immune analysis for D1 and last D.Results. RFW by creatinine was in 38 (27 %) of patients and it was absent in 103 (73 %) of patients. RFW group with the increased NGAL content differed from patients without RFW by the more occurrence of hypertonic disease, diabetes mellitus, ІHD and NYHA IV at admission (all p &lt;0,05). At the analysis of patients with RFW depending on MDRD it was established, that patients with MDRD &lt;60 and RFW were essentially older than patients with MDRD in both groups with MDRD &gt; 60 (р &lt;0,05-0,01).Conclusions. RFW in patients with ADHF is connected with the increased intensity of symptoms only at association with NGAL increase in 48 hours. Patients with RFW without NGAL increased didn’t essentially differ from ones without RFWГостра декомпенсована серцева недостатність (ГДСН) залишається провідною причиною госпіталізації хворих у всьому світі. Є достатньо підстав вважати, що погіршення функції нирок (ПФН) є досить гетерогенним за патофізіологією і прогнозом ускладненням ГДСН та репрезентована декількома фенотипами. Визначення таких патофізіологічно обґрунтованих фенотипів у так званих «вологих і теплих» хворих з ГДСН стало метою даного дослідженн

Introduction to a healthy lifestyle the population of Krasnoyarsk

The article discusses the results of sociological research in addressing one of the important tasks of social policy – the formation of a healthy lifestyle the population of Krasnoyarsk. The experience of involving the population to a healthy lifestyle as a social value of preservation of health, which is one of the most important areas of the social practices of the municipalityВ статье рассматриваются результаты социологического исследования в решении одной из важных задач социальной политики – формирование у населения г. Красноярска здорового стиля жизни. Представлен опыт приобщения населения к здоровому образу жизни как социальной ценности сохранения здоровья, что является одним из важнейших направлений социальной практики муниципалитет