Hematological and Biochemical Alterations due to Over Dosage of Enrofloxacin in Cats

Enrofloxacin, an antimicrobial agent used to treat bacterial diseases is well tolerated by cats at recommended dosage (5 mg/kg). To investigate the tolerance of high-dose of the Hipralona Enro-I® (5% enrofloxacin solution) in cats, 28 urban cats (11 males and 17 females) between the weight of 1.3 and 2.4 kg were randomly assigned to a control group (n=4) and three treatment groups (n=8). Each treatment groups were injected low-dose enrofloxacin (5 mg/kg, IM), high-dose enrofloxacin (15 mg/kg, IM), and very high-dose enrofloxacin (25 mg/kg, IM) once daily for seven consecutive days. Blood samples were collected from jugular vein before injection of enrofloxacin in the hind limb muscles of cats as self-control, and at 3rd, 7th, 14th, and 21st days after first drug injection. Samples were tested for various hematological and serum biochemical parameters. The systemic tolerance during experiment was investigated via monitoring of behavior and general physical examination. Hematological and serum biochemical parameters were not significantly different between groups. In addition, there was no statistically difference between various sampling days for any treatment group in each parameter. Furthermore, there was no change in the behavior and the general health condition of cats in the control and the three experimental groups. As serum biochemical indications of hepatotoxication and nephrotoxication were not observed. It was concluded that muscular injection of enrofloxacin in doses up to 25 mg/kg (5ED50) for seven consecutive days was tolerated by cats

Impact of Management Accounting Techniques on Achieve Competitive Advantage

Presently, economic and technological developments are growing faster in an unparalleled way. In that regard, it has made intense competitive and significant role in supporting the economy. Also, it is considered as the most affected one by technological developments such information technology. The study covers seven Iraqi for soft drink firms a survey was conducted using a quantitative approach where the researchers distributed 64 questionnaires to select respondents. The response rate was 78 percent out of the total questionnaires distributed. Management accounting techniques is an independent variable which consists of six tools, namely, TQM (1)BPR(2)ABM (3)ABC (4)TC (5)JIT (6)and was examined in relation to competitive advantage factors as a dependent variable which comprises cost leadership, differentiation and focus. The value of the study is that it points out the influence of Management Accounting Techniques on competitive advantage factors in Iraqi soft drink firms in order to improve firm performance and efficiency. The second aim of this study is to address this gap between the theory and practice of management accounting by exploring the extent of the application of managerial accounting techniques and influence on strategic competitive advantage factor in (ISDFs). The aim of study is to determining the influential role of information systems upon the competitive strategies, in (ISDFs) that follows the competitive advantage which they seek to achieve. The entropy maximum general method has been used to analyze the questionnaire survey. The findings reveal that there is a significant positive relationship between Management Accounting Techniques and competitive advantage.Keywords:, Management Accounting Techniques, Competitive Advantage, entropy, Iraqi Soft Drinks Firms.(1) Total Quality Management (2) Business Process Reengineering (3) Activity Based Management (4) Activity basic cost (5) Target Costing (6) Just in Tim

Investigation of the influence of the properties of the work and tool materials on performance level of Electrical Discharge Machining (EDM) process

Influence of the properties of work and tool materials on material removal rate (MRR), wear ratio (WR), thickness of the recast layer, surface roughness and accuracy of machining in EDM process was investigated. Copper, brass, stainless steel, mild steel and grey cast iron were used in various combinations as work and tool materials. From the experimental results it was observed that the curves of MRR versus machining time show convex behavior, specially after long duration of machining. It was also observed that the MRR and WR are inversely proportional to the melting points of the work and tool materials respectively. Though electrical conductivity of the tool material was found to have influence on tool wear ratio but brass tool was found to have minimum wear ratio although its electrical conductivity was next to copper. From the bar chart of the recast layer thickness it was observed that for all combinations of work and tool material the thickest recast layer was formed in the case of copper electrode. Photo micrographs of the machined surface reveal that micro cavities formed in the cases of lower melting point electrode materials like copper and brass having higher electrical conductivity are comparatively smaller in size (2-3 μm) as compared to the sizes of the micro cavities (8-20 μm) formed in the cases of high melting point electrodes also having lower electrical conductivity. Consequently the machined surface roughness in the latter cases is higher. It was also observed that the tendency of debris concentration is at the middle of the tool job interface resulting in high bottom surface inaccuracy, specially when high melting point work material are machined by low melting point electrodes like brass. On the basis of material removal rate, wear ratio and job surface finish brass electrodes were found to be most suitable

Phytochemistry and Ethnopharmacology of Some Medicinal Plants Used in the Kurdistan Region of Iraq.

The majority of Kurds inhabit a region that includes adjacent parts of Iran, Iraq, Syria and Turkey. This review shows that the traditional medicine is still used by Kurdish peoples and underlines the medicinal value of a great number of plants used locally. The medicinal uses include the treatment of a variety of diseases, ranging from simple stomach-ache to highly complicate male and female disorders; even sexual weakness and kidney stones are treated by plants. The majority of the plants that are used are for curing gastro-intestinal disorders and inflammation, followed by urinary tract disorders, skin burns, irritations and liver problems. In the last part of this paper, we also report the first results of our ongoing research project on the constituents of some uninvestigated Kurdish medicinal plants. The C-glycosylflavone embinin, the α-methylene acyl derivative 6-tuliposide A, and the iridoids aucubin and ajugol were isolated for the first time from Iris persica, Tulipa systole and Verbascum calvum, respectively. These plants are traditionally used against inflammation, pain, and skin burns

Beyond metropolitanism and nativism: Re-grounding media theory

While de-Westernisation is an interesting political intervention in media theory, analytically it offers little. We critique this approach through six inter-related arguments. The first point of critique challenges the putative singularity of the West. The second line of enquiry raises questions about the emergence of new academic disciplines and their intellectual offerings. Our third point is that the call to de-Westernise Media Studies is naïve, ignores history and the long patterns of global interconnectedness that have mutually formed the West/Rest. The fourth argument is that "de- Westernisation" suggests that the theory and methods of Media Studies offer nothing of use outside their original birthplaces, while the fifth argument is the conceptual danger of nativism. The sixth critique centres on the problem of essentialising culture as a determinate object. Examining the contemporary media practices of the Islamic Republic of Iran, we suggest that the true alternative to a repressive theocracy is its internal challenge by women, students and other parts of civil society that offers a critical third way beyond the binary divide

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability