43 research outputs found
First Results from COPSS: The CO Power Spectrum Survey
We present constraints on the abundance of carbon monoxide in the early universe from the CO Power Spectrum Survey. We utilize a data set collected between 2005 and 2008 using the SunyaevâZel'dovich Array (SZA), which was previously used to measure arcminute-scale fluctuations of the cosmic microwave background. This data set features observations of 44 fields, covering an effective area of 1.7 square degrees, over a frequency range of 27â35 GHz. Using the technique of intensity mapping, we are able to probe the CO(1â0) transition, with sensitivity to spatial modes between k = 0.5â2 h Mpc^(â1) over a range in redshift of z = 2.3â3.3, spanning a comoving volume of 3.6 Ă 10^6 h^(â3) Mpc^3. We demonstrate our ability to mitigate foregrounds, and present estimates of the impact of continuum sources on our measurement. We constrain the CO power spectrum to P_(CO) < 2.6 Ă 10^4 ÎŒK^2 (h^(â1) Mpc)^3, or Î^2_(CO)(k = 1 h Mpc^(â1)) < 1.3 Ă 10^3 ÎŒK^2, at 95% confidence. This limit resides near optimistic predictions for the CO power spectrum. Under the assumption that CO emission is proportional to halo mass during bursts of active star formation, this corresponds to a limit on the ratio of CO(1â0) luminosity to host halo mass of A_(CO) < 1.2 Ă 10^(â5) Lâ_ M_â^(â1). Further assuming a Milky Way-like conversion factor between CO luminosity and molecular gas mass (α_(CO) = 4.3 M_â (K km s^(â1) pc^(â2))^(â1)), we constrain the global density of molecular gas to Ï_(z~3) (M_H_2) â©œ 2.8 x 10^8 M_â Mpc^(-3)
The Allen Telescope Array Twenty-centimeter Survey - A 690-Square-Degree, 12-Epoch Radio Dataset - I: Catalog and Long-Duration Transient Statistics
We present the Allen Telescope Array Twenty-centimeter Survey (ATATS), a
multi-epoch (12 visits), 690 square degree radio image and catalog at 1.4GHz.
The survey is designed to detect rare, very bright transients as well as to
verify the capabilities of the ATA to form large mosaics. The combined image
using data from all 12 ATATS epochs has RMS noise sigma = 3.94mJy / beam and
dynamic range 180, with a circular beam of 150 arcsec FWHM. It contains 4408
sources to a limiting sensitivity of S = 20 mJy / beam. We compare the catalog
generated from this 12-epoch combined image to the NRAO VLA Sky Survey (NVSS),
a legacy survey at the same frequency, and find that we can measure source
positions to better than ~20 arcsec. For sources above the ATATS completeness
limit, the median flux density is 97% of the median value for matched NVSS
sources, indicative of an accurate overall flux calibration. We examine the
effects of source confusion due to the effects of differing resolution between
ATATS and NVSS on our ability to compare flux densities. We detect no
transients at flux densities greater than 40 mJy in comparison with NVSS, and
place a 2-sigma upper limit on the transient rate for such sources of 0.004 per
square degree. These results suggest that the > 1 Jy transients reported by
Matsumura et al. (2009) may not be true transients, but rather variable sources
at their flux density threshold.Comment: 41 pages, 19 figures, ApJ accepted; corrected minor typo in Table
The Allen Telescope Array Pi GHz Sky Survey I. Survey Description and Static Catalog Results for the Bootes Field
The Pi GHz Sky Survey (PiGSS) is a key project of the Allen Telescope Array.
PiGSS is a 3.1 GHz survey of radio continuum emission in the extragalactic sky
with an emphasis on synoptic observations that measure the static and
time-variable properties of the sky. During the 2.5-year campaign, PiGSS will
twice observe ~250,000 radio sources in the 10,000 deg^2 region of the sky with
b > 30 deg to an rms sensitivity of ~1 mJy. Additionally, sub-regions of the
sky will be observed multiple times to characterize variability on time scales
of days to years. We present here observations of a 10 deg^2 region in the
Bootes constellation overlapping the NOAO Deep Wide Field Survey field. The
PiGSS image was constructed from 75 daily observations distributed over a
4-month period and has an rms flux density between 200 and 250 microJy. This
represents a deeper image by a factor of 4 to 8 than we will achieve over the
entire 10,000 deg^2. We provide flux densities, source sizes, and spectral
indices for the 425 sources detected in the image. We identify ~100$ new flat
spectrum radio sources; we project that when completed PiGSS will identify 10^4
flat spectrum sources. We identify one source that is a possible transient
radio source. This survey provides new limits on faint radio transients and
variables with characteristic durations of months.Comment: Accepted for publication in ApJ; revision submitted with extraneous
figure remove
The Allen Telescope Array Pi GHz Sky Survey I. Survey Description and Static Catalog Results for the Bootes Field
The Pi GHz Sky Survey (PiGSS) is a key project of the Allen Telescope Array.
PiGSS is a 3.1 GHz survey of radio continuum emission in the extragalactic sky
with an emphasis on synoptic observations that measure the static and
time-variable properties of the sky. During the 2.5-year campaign, PiGSS will
twice observe ~250,000 radio sources in the 10,000 deg^2 region of the sky with
b > 30 deg to an rms sensitivity of ~1 mJy. Additionally, sub-regions of the
sky will be observed multiple times to characterize variability on time scales
of days to years. We present here observations of a 10 deg^2 region in the
Bootes constellation overlapping the NOAO Deep Wide Field Survey field. The
PiGSS image was constructed from 75 daily observations distributed over a
4-month period and has an rms flux density between 200 and 250 microJy. This
represents a deeper image by a factor of 4 to 8 than we will achieve over the
entire 10,000 deg^2. We provide flux densities, source sizes, and spectral
indices for the 425 sources detected in the image. We identify ~100$ new flat
spectrum radio sources; we project that when completed PiGSS will identify 10^4
flat spectrum sources. We identify one source that is a possible transient
radio source. This survey provides new limits on faint radio transients and
variables with characteristic durations of months.Comment: Accepted for publication in ApJ; revision submitted with extraneous
figure remove
Observing the Evolution of the Universe
How did the universe evolve? The fine angular scale (l>1000) temperature and
polarization anisotropies in the CMB are a Rosetta stone for understanding the
evolution of the universe. Through detailed measurements one may address
everything from the physics of the birth of the universe to the history of star
formation and the process by which galaxies formed. One may in addition track
the evolution of the dark energy and discover the net neutrino mass.
We are at the dawn of a new era in which hundreds of square degrees of sky
can be mapped with arcminute resolution and sensitivities measured in
microKelvin. Acquiring these data requires the use of special purpose
telescopes such as the Atacama Cosmology Telescope (ACT), located in Chile, and
the South Pole Telescope (SPT). These new telescopes are outfitted with a new
generation of custom mm-wave kilo-pixel arrays. Additional instruments are in
the planning stages.Comment: Science White Paper submitted to the US Astro2010 Decadal Survey.
Full list of 177 author available at http://cmbpol.uchicago.ed
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.</p
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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Brief Report
BackgroundHIV infection is associated with low bone mineral density (BMD) and alterations in adipokines, which may mediate the relationship between fat and bone.ObjectiveTo evaluate the relationship of adiponectin and leptin with BMD in HIV-infected and uninfected women.MethodsWe measured BMD over 5 years at the lumbar spine, total hip (TH), and femoral neck (FN) using dual-energy X-ray absorptiometry in 318 HIV-infected and 122 HIV-uninfected participants of the multicenter Women's Interagency HIV Study (WIHS). Total adiponectin and leptin were assayed on stored sera. Multivariable linear mixed models assessed the effects of adipokines and HIV status on BMD.ResultsHIV-infected women had higher adiponectin (median 6.2 vs. 5.6 ÎŒg/mL,) but lower leptin (11.7 vs. 19.8 ng/mL) levels at baseline (both P < 0.05) compared with HIV-uninfected women. HIV infection was associated with lower BMD at the lumbar spine (-0.074 g/cm), FN (-0.049 g/cm), and TH (-0.047 g/cm) (all P < 0.05) after adjusting for demographic, behavioral, and metabolic factors. HIV infection remained associated with lower BMD at each site, with little change in the effect sizes after additional adjustment for adiponectin or leptin. Among HIV-infected women, higher adiponectin was associated with lower TH BMD (-0.025 g/cm per 10-fold increase, P = 0.035), whereas higher leptin was associated with higher BMD at FN (+0.027 g/cm per 10-fold increase, P = 0.005) and TH (+0.019 g/cm, P = 0.028). After multivariable adjustment, the adipokines showed little association with BMD at any site (P > 0.8 for adiponectin; P > 0.2 for leptin).ConclusionsAlterations in serum adiponectin and leptin do not explain low BMD in HIV-infected women