Body, performance and materiality: For a non-hermeneutical view in studies on sports

A partir da obra de Gumbrecht, mas não somente dela, pretendemos sinalizar as aproximações passíveis de serem feitas entre a teoria das materialidades e os estudos sobre o esporte. Em outras palavras, como investigar o esporte adotando como repertório teórico as possibilidades levantadas pela materialidade da comunicação. Nesse sentido, revisamos brevemente a mudança de paradigma teórico em curso no campo das Ciências Sociais, bem como apontamos, na conclusão, caminhos de pesquisa a partir das ideias debatidas ao longo deste trabalho.Palavras-chave: esporte, materialidade, corpo.From the work of Gumbrecht, but not only from it, we want to show the approaches that can be made between the theory of materialities and studies about sport. In other words, we intend to investigate sports adopting the possibilities given by the materiality of communication as a theoretical repertoire. In this sense, we briefly review the theoretical paradigm shift that is taking place in the field of Social Sciences and we point out, in the conclusion, research paths from the ideas discussed throughout this work.Key words: sport, materiality, body

Futebol, nação e representações: a importância do estilo “Futebol-arte” na construção da identidade nacional

In this article, we will highlight the importance of soccer in the construction of Brazil’s national identity in the 1930s. Our alleged style of play, “art soccer”, was built in dense narratives and surrounded by ideological disputes of different social currents in the 1920s and 1930s waging a debate to define a new ideology and what would be the national identity. We will present here the context that allowed the approach of miscegenation as something positive defining an important moment of the racial issue in Brazil, and to intensely associate such ideology with soccer, especially during the World Cup of 1938. Among the main authors and ideas discussed in this article are respectively Gilberto Freyre and his thinking about national identity and Serge Moscovici and his contribution to the study of social representation.Keywords: soccer, representations, nation.Neste artigo, destacaremos a importância do futebol na construção da identidade nacional nos anos 1930. Nosso suposto estilo de jogo, o futebol-arte, foi construído em densas narrativas e cercado de disputas ideológicas de diferentes correntes sociais nos anos 1920 e 1930, que travavam um debate para definir uma nova ideologia e o que viria a ser a identidade nacional. Apresentaremos aqui o contexto que permitiu a abordagem da miscigenação como algo positivo, demarcando um importante momento da questão racial no Brasil, além de associar tal ideologia de maneira intensa com o futebol, principalmente durante a Copa do Mundo de 1938. Dentre os principais autores e ideias abordados neste artigo, estão, respectivamente, Gilberto Freyre e seu pensamento acerca da identidade nacional, e Serge Moscovici e sua contribuição aos estudos da representação social.Palavras-chave: futebol, representações, nação

Futebol, nação e representações: a importância do estilo “Futebol-arte” na construção da identidade nacional

In this article, we will highlight the importance of soccer in the construction of Brazil’s national identity in the 1930s. Our alleged style of play, “art soccer”, was built in dense narratives and surrounded by ideological disputes of different social currents in the 1920s and 1930s waging a debate to define a new ideology and what would be the national identity. We will present here the context that allowed the approach of miscegenation as something positive defining an important moment of the racial issue in Brazil, and to intensely associate such ideology with soccer, especially during the World Cup of 1938. Among the main authors and ideas discussed in this article are respectively Gilberto Freyre and his thinking about national identity and Serge Moscovici and his contribution to the study of social representation.Keywords: soccer, representations, nation.Neste artigo, destacaremos a importância do futebol na construção da identidade nacional nos anos 1930. Nosso suposto estilo de jogo, o futebol-arte, foi construído em densas narrativas e cercado de disputas ideológicas de diferentes correntes sociais nos anos 1920 e 1930, que travavam um debate para definir uma nova ideologia e o que viria a ser a identidade nacional. Apresentaremos aqui o contexto que permitiu a abordagem da miscigenação como algo positivo, demarcando um importante momento da questão racial no Brasil, além de associar tal ideologia de maneira intensa com o futebol, principalmente durante a Copa do Mundo de 1938. Dentre os principais autores e ideias abordados neste artigo, estão, respectivamente, Gilberto Freyre e seu pensamento acerca da identidade nacional, e Serge Moscovici e sua contribuição aos estudos da representação social.Palavras-chave: futebol, representações, nação

Uma abordagem para avaliar o potencial de agroecossistemas em prover serviços ambientais

The objective of this work was to present an approach to evaluate soil functions in agroecosystems and their impact on environmental services (ES). An approach with case studies was proposed to assess the relationship between the establishment and management of agroecosystems, in three Brazilian biomes (Atlantic Forest, Cerrado, and Caatinga), and their environmental services provision, considering the specificities of each area. A set of soil parameters that can be used as indicators to monitor changes in the agroecosystem was also proposed. The environmental services types most affected by the establishment and management of the agroecosystems were the supporting and provisioning services, showing the potential of agricultural management in providing multiple services, besides food, fiber, and energy. “No fire use” and “agricultural consortium” were the criteria for the establishment and management of agroecosystems with greater potential to increase environmental services provision, whereas biomass stock in soil and litter was the most appropriate soil parameter to be used as an indicator to monitor the impact of agroecosystems in environmental services provision.O objetivo deste trabalho foi apresentar uma abordagem para avaliar as funções do solo em agroecossistemas e seus impactos sobre os serviços ambientais (SA). Uma abordagem com estudo de casos foi proposta para analisar a relação entre o estabelecimento e o manejo de agroecossistemas, em três biomas brasileiros (Floresta Atlântica, Cerrado e Caatinga), e a sua correlação com a prestação de serviços ambientais, tendo-se levado em consideração as especificidades de cada área. Também foi proposto um conjunto de parâmetros do solo que possam ser utilizados como indicadores para monitorar as alterações no agroecossistema. Observou-se que os tipos de serviços ambientais mais afetados pela implantação e pela gestão dos agroecossistemas são os desuporte e provisão, o que mostra o potencial que o manejo agrícola tem de fornecer múltiplos serviços, além de alimentos, fibras e energia. “Sem uso de fogo” e “consórcios agrícolas” foram os critérios usados na implantação e a gestão de agroecossistemas com maior potencial em aumentar a prestação de serviços ambientais, enquanto o estoque de biomassa no solo e na serapilheira foi o parâmetro do solo mais adequado para uso como indicador no monitoramento do impacto do agroecossistema na prestação de serviços ambientais

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive nuclear factor κB (NF-κB) is a common culprit in both cancers. Previously, we discovered that protein arginine methyltransferase 5 (PRMT5) methylated and activated NF-κB. Here, we show that PRMT5 is highly expressed in PDAC and CRC. Overexpression of PRMT5 promoted cancer progression, while shRNA knockdown showed an opposite effect. Using an innovative AlphaLISA high throughput screen, we discovered a lead compound, PR5-LL-CM01, which exhibited robust tumor inhibition effects in both cancers. An in silico structure prediction suggested that PR5-LL-CM01 inhibits PRMT5 by binding with its active pocket. Importantly, PR5-LL-CM01 showed higher anti-tumor efficacy than the commercial PRMT5 inhibitor, EPZ015666, in both PDAC and CRC. This study clearly highlights the significant potential of PRMT5 as a therapeutic target in PDAC and CRC, and establishes PR5-LL-CM01 as a promising basis for new drug development in the future

The construction of a soccer idol in the press: a case study

O artigo, perpassando as edições dos meses de abril, maio e junho de 2011 dos jornais O Globo (Rio de Janeiro) e O Estado de S. Paulo, procura investigar como a imprensa escrita está construindo a imagem do futebolista brasileiro Neymar(Neymar da Silva Santos Júnior). A pesquisa busca identificar quais recursos são acionados na tentativa de aproximar o jovem atleta à narrativa clássica do herói e/ou às “essencializações” que os brasileiros fazem de si mesmo. The article aims to investigate how the media is building the public image of soccer player Neymar. In order to do this we analyzed the O Globo and Estado de S. Paulo newpapers during the months of April, May and June of 2011. The research proposes to identify what sources are activated in attempting to bring the young athlete to the classic narrative of the hero and/or the “essentializations” that Brazilians usually make of themselves.El artículo, que repasa las ediciones de los meses de abril, mayo y junio de 2011 de los periódicos O Globo (Rio de Janeiro) y O Estado de S. Paulo, investiga cómo la prensa escrita está construyendo la imagen del futbolista brasileño Neymar (Neymar da Silva Santos Júnior). Se busca identificar qué recursos se accionan en el intento de aproximar al joven atleta a la narrativa clásica del héroe y/o a las “esencializaciones” que los brasileños hacen de si mismos

Multimessenger astronomy with pulsar timing and X-ray observations of massive black hole binaries

We demonstrate that very massive (>10^8\msun), cosmologically nearby (z<1) black hole binaries (MBHBs), which are primary targets for ongoing and upcoming pulsar timing arrays (PTAs), are particularly appealing multimessenger carriers. According to current models for massive black hole formation and evolution, the planned Square Kilometer Array (SKA) will collect gravitational wave signals from thousands of such massive systems, being able to individually resolve and locate in the sky several of them (maybe up to a hundred). By employing a standard model for the evolution of MBHBs in circumbinary discs, with the aid of dedicated numerical simulations, we characterize the gas-binary interplay, identifying possible electromagnetic signatures of the PTA sources. We concentrate our investigation on two particularly promising scenarios in the high energy domain, namely, the detection of X-ray periodic variability and of double broad K\alpha iron lines. Up to several hundreds of periodic X-ray sources with a flux >10^-13 erg s^-1 cm^-2 will be in the reach of upcoming X-ray observatories. Double relativistic K\alpha lines may be observable in a handful of low redshift (z<0.3) sources by proposed deep X-ray probes, such as Athena. (Abridged)Comment: 19 pages, 11 figures, submitted to MNRAS, minor revision of the reference lis

Ka-Band Autonomous Formation Flying Sensor

Ka-band integrated range and bearing-angle formation sensor called the Autonomous Formation Flying (AFF) Sensor has been developed to enable deep-space formation flying of multiple spacecraft. The AFF Sensor concept is similar to that of the Global Positioning System (GPS), but the AFF Sensor would not use the GPS. The AFF Sensor would reside in radio transceivers and signal-processing subsystems aboard the formation-flying spacecraft. A version of the AFF Sensor has been developed for initial application to the two-spacecraft StarLight optical-interferometry mission, and several design investigations have been performed. From the prototype development, it has been concluded that the AFF Sensor can be expected to measure distances and directions with standard deviations of 2 cm and 1 arc minute, respectively, for spacecraft separations ranging up to about 1 km. It has also been concluded that it is necessary to optimize performance of the overall mission through design trade-offs among the performance of the AFF Sensor, the field of view of the AFF Sensor, the designs of the spacecraft and the scientific instruments that they will carry, the spacecraft maneuvers required for formation flying, and the design of a formation-control system

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a highly potent NA inhibitor, laninamivir, has been approved for use in Japan. Laninamivir is effective using a single inhaled dose via its octanoate prodrug (CS-8958) and has been demonstrated to be effective against oseltamivir-resistant NA in vitro. However, effectiveness of laninamivir octanoate prodrug against oseltamivir-resistant influenza infection in adults has not been demonstrated. NA is classified into 2 groups based upon phylogenetic analysis and it is becoming clear that each group has some distinct structural features. Recently, we found that pH1N1 N1 NA (p09N1) is an atypical group 1 NA with some group 2-like features in its active site (lack of a 150-cavity). Furthermore, it has been reported that certain oseltamivir-resistant substitutions in the NA active site are group 1 specific. In order to comprehensively evaluate the effectiveness of laninamivir, we utilized recombinant N5 (typical group 1), p09N1 (atypical group 1) and N2 from the 1957 pandemic H2N2 (p57N2) (typical group 2) to carry out in vitro inhibition assays. We found that laninamivir and its octanoate prodrug display group specific preferences to different influenza NAs and provide the structural basis of their specific action based upon their novel complex crystal structures. Our results indicate that laninamivir and zanamivir are more effective against group 1 NA with a 150-cavity than group 2 NA with no 150-cavity. Furthermore, we have found that the laninamivir octanoate prodrug has a unique binding mode in p09N1 that is different from that of group 2 p57N2, but with some similarities to NA-oseltamivir binding, which provides additional insight into group specific differences of oseltamivir binding and resistance