EFICACIA Y SEGURIDAD DEL ESTILETE LUMINOSO VS LARINGOSCOPÍA CONVENCIONAL PARA DISMINUIR LA RESPUESTA ADRENÉRGICA DURANTE LA INTUBACIÓN OROTRAQUEAL EN PACIENTES SOMETIDOS A ANESTESIA GENERAL BALANCEADA, EN EL HOSPITAL GENERAL DR. NICOLÁS SAN JUAN, DURANTE EL PERIODO MARZO-AGOSTO 2016.

Se incluyeron 60 pacientes ASA I, entre 18-60 años, de ambos sexos programados para cirugías electivas bajo anestesia general balanceada, de Marzo a Agosto del 2016. Los pacientes del Grupo en estudio fueron intubados con estilete luminoso y los del Grupo control con laringoscopía convencinal. La técnica de inducción de la anestesia fue estandarizada. Los parámetros hemodinámicos de frecuencia cardíaca, presión arterial se registraron al inicio del estudio, después de la ansiolisis, después de la inducción, después de la intubación traqueal y 3 minutos después de la intubación traquealLa laringoscopia y la intubación traqueal se asocian a menudo con hipertensión, taquicardia y un aumento en las concentraciones de catecolaminas en plasma. El presente estudio se realizó para comprobar si el estilete luminoso es más eficaz y seguro que la laringoscopia convencional para disminuir la respuesta adrenérgica durante la intubación traquea

Maleimide end-functionalized poly(2-oxazoline)s by the functional initiator route : synthesis and (bio) conjugation

The synthesis of poly(2-ethyl-2-oxazoline)s with a maleimide group at the a chain end was carried out from new sultanate ester initiators bearing a furan-protected maleimide group. The conditions of the polymerization were optimized for 50 degrees C using conventional heating (in contrast to microwave irradiation) to counteract the thermal lability of the cycloadduct introduced to protect the maleimide double bond. At this temperature, a tosylate variant was found to be unable to initiate the polymerization after several days. The controlled polymerization of 2-ethyl-2-oxazoline with a nosylate derivative was, however, successful as shown by kinetic experiments monitored by gas chromatography (GC) and size-exclusion chromatography (SEC). Poly(2-ethyl-oxazoline)s of various molar masses (4500 < M-n < 12 000 g mol(-1)) with narrow dispersity (D < 1.2) were obtained. The stability of the protected maleimide functionality during the polymerization, its deprotection, and the reactivity of the deprotected end group by coupling with a model thiol molecule were proven by H-1 NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Finally, the conjugation of maleimide-functionalized poly(2-oxazoline) to a model protein (bovine serum albumin) was demonstrated by gel electrophoresis and MALDI-ToF mass spectrometry

Maleimide end-functionalized poly(2-oxazoline)s by the functional initiator route: synthesis and (bio)conjugation

The synthesis of poly(2-ethyl-2-oxazoline)s with a maleimide group at the α chain end was carried out from new sulfonate ester initiators bearing a furan-protected maleimide group. The conditions of the polymerization were optimized for 50 °C using conventional heating (in contrast to microwave irradiation) to counteract the thermal lability of the cycloadduct introduced to protect the maleimide double bond. At this temperature, a tosylate variant was found to be unable to initiate the polymerization after several days. The controlled polymerization of 2-ethyl-2-oxazoline with a nosylate derivative was, however, successful as shown by kinetic experiments monitored by gas chromatography (GC) and size-exclusion chromatography (SEC). Poly(2-ethyl-oxazoline)s of various molar masses (4500 < Mn < 12 000 g mol−1) with narrow dispersity (Đ < 1.2) were obtained. The stability of the protected maleimide functionality during the polymerization, its deprotection, and the reactivity of the deprotected end group by coupling with a model thiol molecule were proven by 1H NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Finally, the conjugation of maleimide-functionalized poly(2-oxazoline) to a model protein (bovine serum albumin) was demonstrated by gel electrophoresis and MALDI-ToF mass spectrometry

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents

Copyright © 2019 American Chemical Society. The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2-oxazoline) (PEtOx) macromonomers (MM) were prepared by cationic ring-opening polymerization. ROMP of these MMs produced bottlebrush copolymers with PEtOx side chains. In addition, PEtOx-based branched MMs bearing a terminal alkyne group were prepared and conjugated to an azide-containing bis-spirocyclohexyl nitroxide via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). ROMP of this branched MM, followed by in situ cross-linking, provided PEtOx-based brush-arm star polymers (BASPs) with nitroxide radicals localized at the core-shell interface. These PEtOx-based nitroxide-containing BASPs displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials, making them promising as organic radical contrast agents for metal-free magnetic resonance imaging (MRI)

Evaluación de la ganancia de peso según índice de masa corporal pregestacional (IMCp) en mujeres adultas con embarazo gemelar y embarazo único que asisten al instituto nacional de perinatología

El aumento de la incidencia de embarazos gemelares (EG), se ha debido principalmente a las terapias de reproducción asistida (TRA). Esta tendencia se ve reflejada en el aumento de las tasas de morbilidad y mortalidad maternas y neonatales, ya que este tipo de embarazo es considerado de alto riesgo. Mientras que las recomendaciones nutricias de ganancia de peso para mujeres con embarazo único (EU) se encuentran bien documentadas, existe escasa información para EG

Thioacetate-based initiators for the synthesis of thiol-end-functionalized poly(2-oxazoline)s

New functional initiators for the cationic ring-opening polymerization of 2-alkyl-2-oxazolines are described to introduce a thiol moiety at the alpha terminus. Both tosylate and nosylate initiators carrying a thioacetate group are obtained in multigram scale, from commercial reagents in two steps, including a phototriggered thiol-ene radical addition. The nosylate derivative gives access to a satisfying control over the cationic ring-opening polymerization of 2-ethyl-2-oxazoline, with dispersity values lower than 1.1 during the entire course of the polymerization, until full conversion. Cleavage of the thioacetate end group is rapidly achieved using triazabicyclodecene, thereby leading to a mercapto terminus. The latter gives access to a new subgeneration of alpha-functional poly(2-oxazoline)s (butyl ester,N-hydroxysuccinimidyl ester, furan) by Michael addition with commercial (meth)acrylates. The amenability of the mercapto-poly(2-ethyl-2-oxazoline) for covalent surface patterning onto acrylated surfaces is demonstrated in a microchannel cantilever spotting (mu CS) experiment, characterized by X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary-ion mass spectrometry (ToF-SIMS)

Thioacetate‐Based Initiators for the Synthesis of Thiol‐End‐Functionalized Poly(2‐oxazoline)s

New functional initiators for the cationic ring-opening polymerization of 2-alkyl-2-oxazolines are described to introduce a thiol moiety at the alpha terminus. Both tosylate and nosylate initiators carrying a thioacetate group are obtained in multigram scale, from commercial reagents in two steps, including a phototriggered thiol-ene radical addition. The nosylate derivative gives access to a satisfying control over the cationic ring-opening polymerization of 2-ethyl-2-oxazoline, with dispersity values lower than 1.1 during the entire course of the polymerization, until full conversion. Cleavage of the thioacetate end group is rapidly achieved using triazabicyclodecene, thereby leading to a mercapto terminus. The latter gives access to a new subgeneration of alpha-functional poly(2-oxazoline)s (butyl ester,N-hydroxysuccinimidyl ester, furan) by Michael addition with commercial (meth)acrylates. The amenability of the mercapto-poly(2-ethyl-2-oxazoline) for covalent surface patterning onto acrylated surfaces is demonstrated in a microchannel cantilever spotting (mu CS) experiment, characterized by X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary-ion mass spectrometry (ToF-SIMS)