Challenges in identifying and interpreting organizational modules in morphology

Form is a rich concept that agglutinates information about the proportions and topological arrangement of body parts. Modularity is readily measurable in both features, the variation of proportions (variational modules) and the organization of topology (organizational modules). The study of variational modularity and of organizational modularity faces similar challenges regarding the identification of meaningful modules and the validation of generative processes; however, most studies in morphology focus solely on variational modularity, while organizational modularity is much less understood. A possible cause for this bias is the successful development in the last twenty years of morphometrics, and specially geometric morphometrics, to study patters of variation. This contrasts with the lack of a similar mathematical framework to deal with patterns of organization. Recently, a new mathematical framework has been proposed to study the organization of gross anatomy using tools from Network Theory, so‐called Anatomical Network Analysis (AnNA). In this essay, I explore the potential use of this new framework—and the challenges it faces in identifying and validating biologically meaningful modules in morphological systems—by providing working examples of a complete analysis of modularity of the human skull and upper limb. Finally, I suggest further directions of research that may bridge the gap between variational and organizational modularity studies, and discuss how alternative modeling strategies of morphological systems using networks can benefit from each other

Comparison of musculoskeletal networks of the primate forelimb

Anatomical network analysis is a framework for quantitatively characterizing the topological organization of anatomical structures, thus providing a way to compare structural integration and modularity among species. Here we apply this approach to study the macroevolution of the forelimb in primates, a structure whose proportions and functions vary widely within this group. We analyzed musculoskeletal network models in 22 genera, including members of all major extant primate groups and three outgroup taxa, after an extensive literature survey and dissections. The modules of the proximal limb are largely similar among taxa, but those of the distal limb show substantial variation. Some network parameters are similar within phylogenetic groups (e.g., non-primates, strepsirrhines, New World monkeys, and hominoids). Reorganization of the modules in the hominoid hand compared to other primates may relate to functional changes such as coordination of individual digit movements, increased pronation/supination, and knuckle-walking. Surprisingly, humans are one of the few taxa we studied in which the thumb musculoskeletal structures do not form an independent anatomical module. This difference may be caused by the loss in humans of some intrinsic muscles associated with the digits or the acquisition of additional muscles that integrate the thumb more closely with surrounding structures

First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans

Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, network analysis reveals that the hindlimb displays a pattern opposite to that of the forelimb: Pan big toe is typically seen as more independently mobile, but humans are actually the ones that have a separate module exclusively related to its movements. Different fore- vs hindlimb patterns are also seen for anatomical network complexity (i.e., complexity in the arrangement of bones and muscles). For instance, the human hindlimb is as complex as that of chimpanzees but the human forelimb is less complex than in Pan. Importantly, in contrast to the analysis of morphological integration using morphometric approaches, network analyses do not support the prediction that forelimb and hindlimb are more dissimilar in species with functionally divergent limbs such as bipedal humans

Cooperative Education in Green Chemistry: The Spanish Experience

A common postgraduate training in Green Chemistry is currently being carried out by several Spanish universities. This initiative considers the corresponding Máster and PhD programs in Sustainable Chemistry and has been successfully achieved with the participation of experts from different Universities and Research Institutions grouped within the coverage of the Spanish Network on Sustainable Chemistry (REDQS). A cooperative effort and a modular design are the key elements that have allowed maintaining the Spanish Interuniversity Máster and PhD programs for more than a decade, providing a high level of quality and a unique possibility, for many students, of being trained at an advanced level in Green Chemistry

Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system

Network theory is increasingly being used to study morphological modularity and integration. Anatomical network analysis (AnNA) is a framework for quantitatively characterizing the topological organization of anatomical structures and providing an operational way to compare structural integration and modularity. Here we apply AnNA for the first time to study the macroevolution of the musculoskeletal system of the head and neck in primates and their closest living relatives, paying special attention to the evolution of structures associated with facial and vocal communication. We show that well-defined left and right facial modules are plesiomorphic for primates, while anthropoids consistently have asymmetrical facial modules that include structures of both sides, a change likely related to the ability to display more complex, asymmetrical facial expressions. However, no clear trends in network organization were found regarding the evolution of structures related to speech. Remarkably, the increase in the number of head and neck muscles – and thus of musculoskeletal structures – in human evolution led to a decrease in network density and complexity in humans

Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition

Tetrapods evolved from within the lobe-finned fishes around 370 Ma. The evolution of limbs from lobe-fins entailed a major re-organization of the skeletal and muscular anatomy of appendages in early tetrapods. Concurrently, a degree of similarity between pectoral and pelvic appendages also evolved. Here, we compared the anatomy of appendages in extant lobe-finned fishes (Latimeria and Neoceratodus) and anatomically plesiomorphic amphibians (Ambystoma, Salamandra) and amniotes (Sphenodon) to trace and reconstruct the musculoskeletal changes that took place during the fins-to-limbs transition. We quantified the anatomy of appendages using network analysis. First, we built network models—in which nodes represent bones and muscles, and links represent their anatomical connections—and then we measured network parameters related to their anatomical integration, heterogeneity, and modularity. Our results reveal an evolutionary transition toward less integrated, more modular appendages. We interpret this transition as a diversification of muscle functions in tetrapods compared to lobe-finned fishes. Limbs and lobe-fins show also a greater similarity between their pectoral and pelvic appendages than ray-fins do. These findings on extant species provide a basis for future quantitative and comprehensive reconstructions of the anatomy of limbs in early tetrapod fossils, and a way to better understand the fins-to-limbs transition

La implicación del alumnado en su propio aprendizaje: Aproximación al concepto de Programación.

La experiencia que presentamos se plantea como respuesta a la necesidad de aprender a programar sentida y expresada por los estudiantes de maestro en un trabajo anterior. Las actividades diseñadas pretenden implicarlos en la construcción del concepto de programación, ayudarles a analizar los presupuestos teóricos que subyacen en las distintas formas de programar con el fin de que tomen conciencia de cómo influye cada una de ellas en la profesionalidad docente, en la idea de escuela y en la forma de enseñar. Este trabajo se inscribe en un proceso de mejora de la metodología universitaria de formación inicial de maestros. Se pretende facilitar un aprendizaje relevante desde la unión de la teoría y la práctica y desde la enseñanza centrada en los estudiantes. Nuestro planteamiento metodológico se basa en la cultura colaborativa como parte importante de la profesionalización del docente. Desde estos presupuestos tratamos de acercar el aula universitaria a la realidad de los centros de enseñanza primaria a través del practicum, utilizando la programación como elemento que aglutina la teoría y la práctica y sirve de vínculo entre la universidad y los centros de enseñanza.The present experience arises in response to the need to learn to program felt and expressed by student teachers in a previous job. Activities designed intend to involve in the construction of the concept of programming, help them analyze the theoretical assumptions that underlie different forms of programming in order to make them aware of how it affects each of them in the teaching profession, the idea of school and how to teach. This work is part of a process improvement methodology university initial teacher training. It is intended to facilitate relevant learning from the union of theory and practice and from teaching student-centered. Our methodological approach is based on the collaborative culture as an important part of the professionalisation of teaching. From these assumptions try to bring the university classroom to the realities of primary schools through the practicum, using programming as an element that brings together theory and practice and serves as a link between universities and schools.Este trabajo se inscribe en un proceso de mejora de la metodología universitaria de formación inicial de maestros que se apoya en la reflexión de los estudiantes sobre la actividad docente de los maestros en ejercicio y la realizada por ellos mismos durante el periodo de prácticas

An analysis of the evolution of hydrometeorological extremes in newspapers: the case of Catalonia, 1982–2006

This contribution analyzes the evolution of perception of certain natural hazards over the past 25 years in a Mediterranean region. Articles from newspapers have been used as indicator. To this end a specific Spanish journal has been considered and an ACCESS database has been created with the summarized information from each news item. The database includes data such as the location of each specific article in the newspaper, its length, the number of pictures and figures, the headlines and a summary of the published information, including all the instrumental data. The study focused on hydrometeorological extremes, mainly floods and droughts, in the northeast of the Iberian Peninsula. The number of headlines per event, trends and other data have been analyzed and compared with "measured" information, in order to identify any bias that could lead to an erroneous perception of the phenomenon. The SPI index (a drought index based on standardized accumulated precipitation) has been calculated for the entire region, and has been used for the drought analysis, while a geodatabase implemented on a GIS built for all the floods recorded in Catalonia since 1900 (INUNGAMA) has been used to analyze flood evolution. Results from a questionnaire about the impact of natural hazards in two specific places have been also used to discuss the various perceptions between rural and urban settings. Results show a better correlation between the news about drought or water scarcity and SPI than between news on floods in Catalonia and the INUNGAMA database. A positive trend has been found for non-catastrophic floods, which is explained by decrease of the perception thresholds, the increase of population density in the most flood-prone areas and changes in land use

Application of the MM5 and the analogous method to heavy rainfall event, the case of 16?18 October 2003 in Catalonia (NE Spain)

International audienceBetween the 16 and 18 October 2003, some amounts of precipitation greater than 225mm and sea waves higher than 8.5m were recorded in Catalonia (NE Spain) and near its coast. Some rivers in the NE of the region were overflowed and the sea swell produced several damages near the coast. In order to analyse this case and to improve the forecasting of events like this, two methodologies have been applied: one deterministic and another one, probabilistic. The deterministic analysis has been made by using the MM5 mesoscale model. A 48 h simulation has been designed for three domains connected with two way nesting and having 54, 18, 6 km horizontal grid resolution and vertical resolution of 23 levels, and it has been initialised with the NCEP Analyses. The simulation suggests that orography played an important role on the precipitation generation (maxima were located where the wind at low levels impinged on the mountain ranges perpendicularly). The strong pressure gradient produced in the North of Catalonia and West part of the Gulf of Lyon, was the responsible of the great marine alteration. On the other hand, the 6 km resolution precipitation forecast for Catalonia is accurate, since it shows a spatial distribution and amounts quite similar to the observations obtained from 315 automatic rain gauges. The analogous technique applied here, considers the meteorological situations similar to the current one, in terms of the 850 and 1000 hPa geopotential fields at 00:00 UTC and 12:00 UTC from the NCEP/NCAR meteorological reanalysis for the period 1958?2003. Two windows have been considered, the first one from 60° N to 30° N and from 30° W to 30° E, and the second one, centred in Catalonia, from 45° N to 37.5° N and from 5° W to 10° E. The best 100 analogous have been selected and the comparison of the results with those obtained for other heavy rainfall events has been also done