Localization of adaptive variants in human genomes using averaged one-dependence estimation.

Statistical methods for identifying adaptive mutations from population genetic data face several obstacles: assessing the significance of genomic outliers, integrating correlated measures of selection into one analytic framework, and distinguishing adaptive variants from hitchhiking neutral variants. Here, we introduce SWIF(r), a probabilistic method that detects selective sweeps by learning the distributions of multiple selection statistics under different evolutionary scenarios and calculating the posterior probability of a sweep at each genomic site. SWIF(r) is trained using simulations from a user-specified demographic model and explicitly models the joint distributions of selection statistics, thereby increasing its power to both identify regions undergoing sweeps and localize adaptive mutations. Using array and exome data from 45 ‡Khomani San hunter-gatherers of southern Africa, we identify an enrichment of adaptive signals in genes associated with metabolism and obesity. SWIF(r) provides a transparent probabilistic framework for localizing beneficial mutations that is extensible to a variety of evolutionary scenarios

Toward a Better Benchmark: Assessing the Utility of Not-at-Fault Traffic Crash Data in Racial Profiling Research

As studies on racial profiling and biased policing have begun to proliferate, researchers are debating which benchmark is most appropriate for comparison with police traffic stop data. Existing benchmark populations, which include populations estimated from census figures, licensed drivers, arrestees, reported crime suspects, and observed drivers and traffic violators, all have significant limitations. This article offers a new, alternative benchmark for police traffic stops, a benchmark that has not been previously applied or tested in a racial profiling research setting. The analysis presented compares traffic observation data, gathered at selected, high volume intersections during an ongoing racial profiling study in Miami-Dade County, Florida, to not-at-fault driver demographic data from two-vehicle crashes at those same intersections. Findings indicate that non-responsible drivers in two-vehicle crashes appear to represent a reasonably accurate estimate of the racial composition of drivers on the roadways at selected intersections and within areas of varying racial composition. The implications of this finding for racial profiling research are discussed, and suggested areas for future inquiry are identified

Train‐the‐trainer: Methodology to learn the cognitive interview

Research has indicated that police may not receive enough training in interviewing cooperative witnesses, specifically in use of the cognitive interview (CI). Practically, for the CI to be effective in real‐world investigations, police investigators must be trained by law enforcement trainers. We conducted a three‐phase experiment to examine the feasibility of training experienced law enforcement trainers who would then train others to conduct the CI. We instructed Federal Bureau of Investigation and local law enforcement trainers about the CI (Phase I); law enforcement trainers from both agencies (n = 4, 100% male, mean age = 50 years) instructed university students (n = 25, 59% female, mean age = 21 years) to conduct either the CI or a standard law enforcement interview (Phase II); the student interviewers then interviewed other student witnesses (n = 50, 73% female, mean age = 22 years), who had watched a simulated crime (phase III). Compared with standard training, interviews conducted by those trained by CI‐trained instructors contained more information and at a higher accuracy rate and with fewer suggestive questions.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147804/1/jip1518_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147804/2/jip1518.pd

The Peculiar Phase Structure of Random Graph Bisection

The mincut graph bisection problem involves partitioning the n vertices of a graph into disjoint subsets, each containing exactly n/2 vertices, while minimizing the number of "cut" edges with an endpoint in each subset. When considered over sparse random graphs, the phase structure of the graph bisection problem displays certain familiar properties, but also some surprises. It is known that when the mean degree is below the critical value of 2 log 2, the cutsize is zero with high probability. We study how the minimum cutsize increases with mean degree above this critical threshold, finding a new analytical upper bound that improves considerably upon previous bounds. Combined with recent results on expander graphs, our bound suggests the unusual scenario that random graph bisection is replica symmetric up to and beyond the critical threshold, with a replica symmetry breaking transition possibly taking place above the threshold. An intriguing algorithmic consequence is that although the problem is NP-hard, we can find near-optimal cutsizes (whose ratio to the optimal value approaches 1 asymptotically) in polynomial time for typical instances near the phase transition.Comment: substantially revised section 2, changed figures 3, 4 and 6, made minor stylistic changes and added reference

Racial Threat, Urban Conditions and Police Use of Force: Assessing the Direct and Indirect Linkages Across Multiple Urban Areas

Traditionally explanations of police use of force have relied on a racial threat perspective. Tests of this perspective, however, typically offer a single indicator of threat (the relative size of the black population) and fail to adequately take into account the complex relationship between racial threat and police use of force. Drawing on racial threat, social disorganization, and police use of force literature, this study hypothesizes that macro-level patterns in police use of force are embedded in the racial and structural composition of cities and the organizational climate of local politics and police departments. The present study examines these relationships using official police use of force data collected in 73 large U.S. cities. Structural equation analyses suggest that structural indicators associated with racial threat and social disorganization/disadvantage impact police use of force indirectly through the influence of police organizational factors. On the other hand, the political climate and the level of social disorganization in urban areas have a direct bearing on the rates of police use of force. The implications of these findings for research and theory on police use of force are discussed

The ubiquity of phenotypic plasticity in plants: A synthesis

Ecology and Evolution Published by John Wiley & Sons Ltd. Adaptation to heterogeneous environments can occur via phenotypic plasticity, but how often this occurs is unknown. Reciprocal transplant studies provide a rich dataset to address this issue in plant populations because they allow for a determination of the prevalence of plastic versus canalized responses. From 31 reciprocal transplant studies, we quantified the frequency of five possible evolutionary patterns: (1) canalized response-no differentiation: no plasticity, the mean phenotypes of the populations are not different; (2) canalized response-population differentiation: no plasticity, the mean phenotypes of the populations are different; (3) perfect adaptive plasticity: plastic responses with similar reaction norms between populations; (4) adaptive plasticity: plastic responses with parallel, but not congruent reaction norms between populations; and (5) nonadaptive plasticity: plastic responses with differences in the slope of the reaction norms. The analysis included 362 records: 50.8% life-history traits, 43.6% morphological traits, and 5.5% physiological traits. Across all traits, 52% of the trait records were not plastic, and either showed no difference in means across sites (17%) or differed among sites (83%). Among the 48% of trait records that showed some sort of plasticity, 49.4% showed perfect adaptive plasticity, 19.5% adaptive plasticity, and 31% nonadaptive plasticity. These results suggest that canalized responses are more common than adaptive plasticity as an evolutionary response to environmental heterogeneity