RATLARDA LOMBER LAMİNEKTOMİ SONRASI OLUSAN EPİDURAL FİBROZİSİN ENGELLENMESİNDE HİPERBARİK OKSİJEN TEDAVİSİNİN ETKİNLİĞİ

Bu çalısmada, deneysel bir hayvan modeli kullanılarak, hiperbarik oksijen tedavisinin, lomber laminektomi cerrahisi sonrasında gelisen epidural fibrozise ve epidural fibrozisin ağrı komplikasyonuna karsı etkilerinin incelenmesi amaçlanmıstır. Bu amaçla Wistar cinsi 24 adet rata L5 – L6 seviyelerinden laminektomi cerrahisi uygulanmıstır. Cerrahilerden sonra denekler rastgele bir sekilde 3 farklı gruba ayrılmıs ve birinci grup her hangi ek bir tedavi almadan 6 hafta boyunca takip edilmistir. Diğer iki gruba ise sırasıyla 3 ve 7 gün boyunca 2,5 ATA basınç altında hiperbarik oksijen tedavisi uygulanmıstır. Altı hafta boyunca von Frey filamanları ile mekanik geri çekme esik değerleri ölçülen denekler altıncı haftanın sonunda sakrifiye edilip cerrahiye uğramıs spinal segmentleri histopatolojik olarak incelenmistir. Đnceleme sonuçlarına göre gruplar arasında epidural fibrozis ve fibroblast yoğunluğu açısından istatistiksel olarak anlamlı bir fark bulunamamıstır ancak hiperbarik oksijen alan gruplarda epidural fibrozisin daha az oranda gelistiği gözlenmistir. Öte yandan mekanik geri çekme esik değerleri açısından yapılan karsılastırmada 4 ve 6. hafta sonunda hiperbarik oksijen tedavisi alan hayvanların, kontrol grubuna kıyasla, istatistiksel olarak anlamlı sekilde daha yüksek geri çekme esik değerlerine sahip olduğu tespit edilmistir. Günümüzde birçok farklı endikasyon için basarı ile uygulanan hiperbarik oksijen tedavisinin, basarısız bel cerrahisi sendromuna neden olan epidural fibrozis üzerine ve epidural fibrozisin en önemli komplikasyonlarından birisi olan ağrı üzerine olumlu etkileri olduğu gösterilmistir. Daha büyük örneklem büyüklüğüne sahip, farklı tedavi protokollerinin daha uzun sürelerde incelendiği çalısmalara ihtiyaç duyulmaktadır.Using an experimental animal model of lumbar laminectomy surgery, this study aims to evaluate the effects of hyperbaric oxygen therapy on both epidural fibrosis formation and pain. For this purpose, 24 adult Wistar rats underwent lumbar laminectomy surgery at L5 and L6 level. Following the surgical procedures, rats were divided into three groups randomly and rats in the control group received no further treatment. Rats in the other two groups received hyperbaric oxygen treatment at 2,5 absolute atmosphere pressure for 3 and 7 days, respectively. Hind paw mechanical withdrawal thresholds were measured using von Frey applicators during the six weeks follow up period. At the end of the 6th week all animals were killed and their spinal segments that underwent lumbar laminectomy were harvested for the histopathological grading of epidural fibrosis and fibroblast density. There was no statistically significant difference among the groups regarding both the extent of peridural fibrosis and fibroblast density; however, the extent of epidural fibrosis in hyperbaric oxygen groups was less than the control group. On the other hand, animals in the hyperbaric oxygen groups demonstrated significantly better hind paw mechanical withdrawal responses compared to the control group on 4th and 6th weeks of the observations. Hyperbaric oxygen therapy which have been proven useful for different indications reduced epidural fibrosis that leads failed back surgery syndrome and pain resulting from it. Further studies with larger cohorts and longer follow up durations are required to reproduce these effects

Effects of tumor necrosis factor alpha blocker adalimumab in experimental spinal cord injury.

Tumor necrosis factor alpha (TNF-α) have proven effects in pathogenesis of neuroinflammation after spinal cord injury (SCI). Current study is designed to evaluate the effects of an anti-TNF-α agent, adalimumab, on spinal cord clip compression injury in rats

ANALYSIS OF NEUROONCOLOGICAL DATA TO PREDICT SUCCESS OF OPERATION THROUGH CLASSIFICATION

Data mining algorithms have been applied in various fields of medicine to get insights about diagnosis and treatment of certain diseases. This gives rise to more research on personalized medicine as patient data can be utilized to predict outcomes of certain treatment procedures. Accordingly, this study aims to create a model to provide decision support for surgeons in Neurooncology surgery. For this purpose, we have analyzed clinical pathology records of Neurooncology patients through various classification algorithms, namely Support Vector Machine, Multi Perceptron and Naive Bayes methods, and compared their performances with the aim of predicting surgery complication. A large number of factors have been considered to classify and predict percentage of patient's complication in surgery. Some of the factors found to be predictive were age, sex, clinical presentation, previous surgery type etc. For classification models built up using Support Vector Machine, Naive Bayes and Multi Perceptron, Classification trials for Support Vector Machine have shown %77.47 generalization accuracy, which was established by 5-fold cross-validation

Primary Intracerebral Alveolar Soft Part Sarcoma in an 11-Year-Old Girl: Case Report and Review of the Literature.

Alveolar soft part sarcoma (ASPS), a rarely observed tumor, is a soft tissue sarcoma with an unidentified cell origin. It constitutes 0.5-1.0% of all soft tissue sarcomas. It may appear in various parts of the body, but mostly observed in the trunk and the extremities. It has a high metastasis potential. To the best of our knowledge, only three cases of primary intracranial ASPS without a demonstrable lesion elsewhere is encountered. An 11-year-old girl was operated because of fronto-parietal mass lesion by craniotomy. Pathological examination revealed ASPS and no primary focus was detected. In spite of radiotherapy and chemotherapy as an adjuvant therapy, after 45 months she had a second operation for recurrence of the tumor. Since it is possible to observe metastases in late phases, up to 30 years, the patients must be followed up for a long period. Although radiotherapy and chemotherapy followed by surgery is the most accepted treatment strategy, the prognosis is still poor