Elaboración del plan estratégico para una empresa de autopartes eléctricas en EE.UU. (2019-2022)

El presente trabajo busca establecer un plan estratégico para el periodo 2019-2022 con el fin de mantener a la empresa económica y financieramente saludable. Delta/Signal Corp. es una empresa proveedora de autopartes eléctricas del sector automotriz fundada en 1992 por Louis Weber. En la actualidad, la compañía se encuentra en un momento difícil debido a que su valor de acción viene cayendo consecutivamente desde el 2008 con alrededor del 35% hasta el 2012. El presente plan estratégico basado en liderazgo en costos traerá beneficios económicos y financieros a lo largo del período, por lo que se deberá implementar y realizar un constante seguimiento a fin de obtener los resultados esperados

Smallholder pig producers and their pork consumption practices in three districts in Uganda

Pig production is thriving in Uganda and the demand for pork is increasing, therefore offering potential for smallholder farmers for increased income through pig production. A multi-disciplinary value chain assessment conducted by the International Livestock Research Institute aimed to identify constraints and opportunities for pig producers as well as shortcomings in the safety of pork products in three districts in Uganda. Tools from participatory research were used to assess pork consumption habits as well as knowledge, attitudes and practices on pork safety among 295 pig producers. Pork is widely popular and mostly consumed well-cooked. However, practices such as roasting may lead to the ingestion of undercooked pork, and accompanying dishes such as raw vegetables may lead to cross-contamination of the meat causing food-borne diseases. The scarcity of data on zoonotic pig pathogens, such as erysipelas, salmonellosis, brucellosis and pork-borne parasites calls for further research

Currículo de bachillerato general unificado: concepciones de los estudiantes de la unidad educativa Jorge Yunes huésped

The curriculum is the expression of the educational project developed by a country or a nation with the objective of promoting the development and socialization of the new generations, the curriculum reflects, to a greater or lesser extent, the educational intentions and establishes guidelines for action. or guidance on how to carry out these intentions, verifying their compliance. Various studies affirm that the study curricula, mainly at the baccalaureate levels, are the basis for continuing education, since, in the event that students do not continue with their studies, the baccalaureate provides them with comprehensive training in citizenship, arts, natural and social sciences, which are related in some way to the labor and economic world. Based on this principle, the following article is presented with the objective of knowing the student perception, in this case, of high school students, about the curriculum taught, identifying in the process, the subjects of lesser-greater mastery and those of lower-higher preference, with a view to obtaining relevant information that allows strengthening aspects of learning. For this purpose, an empirical study with a quantitative approach was carried out, with a simple random sampling and in which 120 high school students from the Jorge Yunes Huésped Educational Unit of the Guayaquil canton, representing 70,6% of the sample, answered questions from a survey. The results obtained evidenced the influence of the teacher's pedagogical section within the student's mastery of the subjects and tastes or preferences.El currículo es la expresión del proyecto educativo desarrollado por un país o una nación con el objetivo de promover el desarrollo y la socialización de las nuevas generaciones, en el currículo se refleja, en mayor o menor medida, las intenciones educativas y establece pautas de acción u orientaciones sobre cómo llevar a cabo estas intenciones, verificando su cumplimiento. Diversos estudios afirman que los currículos de estudio, principalmente en los niveles de bachillerato, son la base para una educación continua, puesto que, en caso de que los estudiantes no prosigan con sus estudios, el bachillerato les proporciona una formación integral en ciudadanía, artes, ciencias naturales y sociales, que se relacionan de alguna manera con el mundo laboral y económico. En base a este principio, se presenta el siguiente artículo con el objetivo de conocer la percepción estudiantil, en este caso, de los estudiantes de bachillerato, sobre el currículo impartido, identificando en el proceso, las asignaturas de menor-mayor dominio y las de menor-mayor preferencia, con miras a obtener información relevante que permita fortalecer aspectos de aprendizaje. Para tales efectos, se realizó un estudio empírico de enfoque cuantitativo, con un muestreo aleatorio simple y en el cual 120 estudiantes de bachillerato de la Unidad Educativa Jorge Yunes Huésped del cantón Guayaquil, que representan un 70,6% de la muestra, respondieron preguntas de una encuesta. Los resultados obtenidos evidenciaron la influencia del apartado pedagógico del docente dentro del dominio estudiantil de las materias y de sus gusto o preferencias

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Diseño geometrico del camino vecinal Buenos Aires – sector gobernador (00+000 km- 05+037.71 km), en el distrito de Moyobamba, provincia de Moyobamba, Región San Martín

The present thesis project called "Geometric Design of the Buenos Aires Neighborhood Road - Governing Sector (0 + 000 km - 05 + 037.71 km) in the Moyobamba District, Moyobamba Province, San Martin Region", was held at the School of Engineering Civil of the National University of San Martin - Tarapoto. The thesis project is focused to make known a quick, economic and optimal solution for road improvement, since in many ways, the neglect in the drainage or the absence of it, causes them to deteriorate and present cracks, fissures , etc. Causing discomfort for users, lack of communication between towns and cities, or in the worst case the total change of the rolling folder. It arose from the need of the population that includes the producers of the Governor sector, to solve the problems caused by the bad state of the access road and that generate high freight costs for the transport of the products grown in the area to the markets of consumption, so that the present research project seeks to solve these problems, starting with the diagnosis of reality in terms of the state of the road and the importance of it. For the geometric design of the road, preliminary studies were carried out in the field, such as traffic study, later in the design calculations were made following the parameters of geometric design standards for unpaved roads and low volume of traffic, determining the elements of design and later the thickness of the necessary affirmed to guarantee the easy and optimal passability of light and heavy vehicles, and thus to facilitate to the producers to transport their products in good state and with low cost of freight towards the markets of consumption. The geometric design of the road was developed by proposing elements of road signs, thus contributing to the socioeconomic development of the producers of the Buenos Aires - Governor sector, as well as putting into practice the knowledge of the Civil Engineering career, obtained in the classrooms faculty.TesisApaEl presente proyecto de tesis denominado “Diseño Geométrico del Camino Vecinal Buenos Aires – Sector Gobernador (0+000 km – 05+037.71 km ) en el Distrito de Moyobamba, Provincia de Moyobamba , Región San Martin”, se desarrolló en la Facultad de Ingeniería Civil de la Universidad Nacional de San Martin – Tarapoto. El proyecto de tesis está enfocado para dar a conocer una solución rápida, económica y óptima para el mejoramiento vial, ya que en muchas vías, el descuido en el drenaje o la ausencia de ésta, hace que las mismas se deterioren y presenten agrietamientos, fisuras, etc. Causando malestar para los usuarios, falta de comunicación entre pueblos y ciudades, o en el peor de los casos el cambio total de la carpeta de rodadura. Surgió ante la necesidad de la población que incluyen los productores del sector Gobernador, de solucionar los problemas causados por el mal estado de la vía de acceso y que generan altos costos de flete para el transporte de los productos cultivados en la zona hacia los mercados de consumo, por lo que el presente proyecto de investigación busca solucionar estos problemas, empezando con el diagnóstico de la realidad en cuanto al estado de la vía y la importancia de la misma. Para el diseño geométrico de la vía se realizaron estudios preliminares en campo como , estudio de tráfico, posteriormente en gabinete se realizaron cálculos de diseño siguiendo los parámetros de las normas de diseño geométrico para carreteras no pavimentadas y de bajo volumen de tránsito, determinando los elementos de diseño y posteriormente el espesor del afirmado necesario para garantizar la fácil y optima transitabilidad de vehículos livianos y pesados, y así facilitar a los productores transportar sus productos en buen estado y con bajo costo de flete hacia los mercados de consumo. Se desarrolló el diseño geométrico de la vía proponiendo, elementos de señalización vial, de esta manera contribuir al desarrollo socioeconómico de los productores del sector Buenos Aires - Gobernador, así mismo poner en práctica los conocimientos de la carrera de Ingeniería Civil, obtenidos en las aulas de la facultad