Un nuevo, curioso y necesario KPI (Key Performance Indicators)

Hoy en día es mas importante que nunca saber dónde está una empresa y hacia dónde va. Pero es necesario analizar la eficacia del marketing y de las ventas mediante indicadores

INFORME CIENTÍFICO – TÉCNICO. Campaña MONTERA‐0412

Informe de la campaña oceanográfica del proyecto MONTERA. Resultados preliminares de la campaña.La campaña MONTERA‐0412 se ha realizado A lo largo de dos zonas de los márgenes continentales del sur de Iberia: el Golfo de Cádiz y el Mar de Alborán. Ambas zonas se caracterizan por la presencia de montes submarinos y la existencia de una intensa actividad tectónica reciente. En el Golfo de Cádiz se estudiaron el Banco de Portimao, relacionado con estructuras diapíricas, y el Banco del Guadalquivir que es un alto de basamento reactivado; por otro lado los bancos estudiados en el Mar de Alborán (Bancos de Avempace, La Herradura e Ibn Batouta junto con la propia dorsal de Alboran) son en todos los casos altos de basamento bético y/o volcánico, cuya última generación de relieve está generada, así mmismo, por la actividad de estructuras tectónicas. La adquisición de nuevos datos permitirá evaluar la tasa de elevación del Banco de Portimao, así como la generación de deslizamiento cohetáneos con dicha elevación. En la zona del Banco del Guadalquivir se tendrá un mejor control de la interferencia de la Masa de Agua Mediterránea con los rasgos morfológicos del margen continental. Por último los datos obtenidos en el Mar de Alborán han permitido analizar por primera vez algunos cuerpos sedimentarios, fundamentamentalmente abanicos profundos y deslizamientos relacionados con los montes submarinos de esta zona, en este sentido se ha caracterizado batimétrica, sísmica y sedimentológicamente un nuevo deslizamiento que hemos denominado “Deslizamiento Montera”. ResumenMONTERA‐0412 scientific cruise has been conducted along two areas of the continental margins of southern Iberia: the Gulf of Cadiz and the Alboran Sea. Both are characterized by the presence of seamounts and the existence of intense recent tectonics activity. In the Gulf of Cadiz have been studied the Portimao Bank, related to diapiric structures, and the Guadalquivir Bank which is a reactivated basement high. In the Alboran Sea, the surveyed banks (Avempace, La Herradura, Ibn Batouta and the Alboran Ridge) are betic basement blocks or volcanic peleoreliefs, but in all cases they must be reactivated by Neogene‐Quaternary tectonic activity. The acquisition of new data enable the uplifted rate asessment of the Portimao Bank and their relation to simultaneous submarine mass flow processes. In the area of the Guadalquivir Bank could be expected a better control of the Mediterranean Water Mass interaction with the morphological features of the continental margin. Finally the data obtained in the Alboran Sea have allowed first analyze some deep sedimentary bodies, basicly deelp sea fans and landslides related to main seamount, in this sense has been characterized bathymetric, seismic and sedimentologically a new mass flow deposit called "Montera Slide".A campanha oceanográfica MONTERA‐0412 foi realizada ao longo de duas áreas das margens continentais do sul da Península Ibérica: o Golfo de Cádiz e o mar de Alborán. Ambas as áreas são caracterizadas pela presença de montes submarinos e pela existência de atividade tectónica no Neogeno‐Quaternário. No Golfo de Cádiz foram estudados o Banco do Portimão e as estruturas diapíricas relacionadas, e o Banco do Guadalquivir um alto de soco paleozóico reativado, por outro lado,os bancos pesquisados no Mar de Alboran (Bancos Avempace, La Herradura, Ibn Batouta e Dorsal de Alboran) sãoem todos os casos formados por altos de soco bético e/ou vulcânico e também por atividade tectónica. A aquisição de novos dados, permitirá a avaliação da taxa de soerguimento do Banco de Portimão e a geração de deslizamento simultâneos com essa elevação. Na área do Banco Guadalquivir ter‐se‐á ummelhor controle da interferência da massa de água do Mediterrâneo com as características morfológicas da margem continental. Finalmente, os dados obtidos no mar de Alborán permitiram analisar primeiramente alguns corpos sedimentares profundos, fundamentamentalmente deslizamentos de terra relacionados com os montes submarinos nesta área, e neste sentido foi caracterizado batimétrica e sísmicamente um novo deslizamento que chamámos "Deslizamento Montera".Le Mission scientifique MONTERA‐0412 a été menée dans deux zones des marges continentales du sud de l'Ibérie: le golfe de Cadix et la mer d'Alboran. Les deux régions sont caractérisées par la présence de monts sous‐marins et l'existence d'une intense activité tectonique récente. Dans le golfe de Cadix ont été étudiés le Banque du Portimao, et les structures diapíriques connexes, et le Banque du Guadalquivir qui est un 10 bloc du zocalo réactivé, de l'autre côté des banques étudié dans la mer d'Alboran (Avempace, La Herradura, Ibn Batouta et la dorsale d’Alboran) sont dans tous les cas blocs du zocle Betico et/ou dernières reliefs volcaniques, et aussi sont généré par l'activité tectonique. L'acquisition de nouvelles données permettant d'évaluer le taux d'élévation de la Banque du Portimao et la génération de glisser cohetáneos. Dans la Banque du Guadalquivir aurez un meilleur contrôle de l'interférence de la messe de l’eau méditerranéenne avec les caractéristiques morphologiques de la marge continentale. Enfin, les données obtenues dans la mer d'Alboran ont permis analyser certains corps sédimentaires profonds, fondamentalement glissements de terrain liés au monts sous‐marins dans ce domaine, en ce sens a été caractérisé bathymétrique, sismique et les sédiment d’un nouveau glissement "Montera Slide".PROGRAMA NACIONAL DE I+D+I. CTM2009-14157-C0

Psychiatric care in university population

[EN] It is well-known that university students experience high levels of mental health problems. University life presents changes and challenges that can be stressful and may affect the mental health of its community. More than 20 years ago, the Social Affairs Service (SAS) of the University of Salamanca started a program that ensured the mental health care in their community. The Psychiatric Care Unit is part of this program and its objectives are: 1) to detect serious mental disorders; 2) treat mild mental disorders; 3) give information to prevent illness and promote mental health; 4) serve as support in patients with previous follow-up that has been discontinued due to the beginning of their studies; 5) liaise with referral psychiatrists

Sur8, a determinant protein in colorectal cancer tumor progression

Resumen del trabajo presentado en el 43rd Annual Meeting of the SEBBM, celebrado en Barcelona (España) del 19 al 21 de julio de 2021.Colorectal cancer (CRC) has the highest incidence rate in the Spanish population. The most important challenge consists on the discovery of efficient disease treatments, due to high mortality rates in highly developed stages. Sur8 is a scaffold protein that positively modulates ERK signaling pathway, which has a major role in the progression and metastasis in colorectal cancer. The main goals of our research are to determine the role that Sur8 plays in the development and progression of CRC and to analyze its possible therapeutic potential. For this purpose, our group has developed an inducible conditional mouse model msur8f/fVillinCreERT2. In order to determine Sur8 action in the colonic tissue, we have developed organoids from the colon epithelium of healthy mice and have analyzed gene expression pattern by an RNAseq approach. Sur8 KO affects oncogenic CRC transcription factors expression, as well as the modulation of some Wnt pathway regulators. In regard to miRNA data, we have observed deregulation of miRNAs related to CRC in Sur8 KO organoids. To determine the role that Sur8 plays in the development and progression of CRC, we have subjected our inducible conditional mice to chemical carcinogenesis and we have observed that Sur8 KO males display less and smaller tumors and do not present any adenocarcinoma. In addition, we have carried out Sur8 silencing in human CRC cell lines by infection with constitutive shRNA lentiviruses. We have observed that Sur8 silencing produces decreases of cell tumor proliferation, and reduction of p-ERK levels. Finally, we are evaluating the effects of putative therapeutic agents against Sur8 in human CRC cell lines. Concretely, we are testing Celastrol, which has been described that binds and blocks the action of Sur8 in vitro. We have observed that Celastrol treatment diminishes the cell tumor proliferation in this model. Altogether, our results indicate that Sur8 may have a determinant role in CRC progression and that Sur8 could be a potential molecular target for the design of novel strategies against CRC

Submarine canyons and related features in the Alboran Sea: continental margins and major isolated reliefs

The analysis of a data set of multibeam bathymetry plus high resolution seismic and parametric profiles allow us to characterize the geomorphologic units on the Alboran Sea-floor as well as the evolution of morpho-sedimentary systems along the Pliocene and Quaternary, later than the main erosive Messinian event. Since the opening of the Gibraltar Straits, the sedimentary evolution of this basin has been controlled by the interchange of water masses between the Atlantic Ocean and the Mediterranean Sea. Basin physiography is also a consequence of the Pliocene-Quaternary compression which has progressively uplifted the sourrounding reliefs and deforms the interior and the margins of the basin. On this scenario, several submarine canyons and gullies have been developed in this basin which traverse especially the northern margin and the flanks of the Northern Alboran Ridge, without affecting the African margins. This fact must be related to the action of bottom contour currents which constitute the main morpho-sedimentary process. The influence of water masses distributed the sedimentary input carried by rivers and coming from the erosion of surrounding ranges. In the southern margin of this basin this influence is stronger and inhibits the development of transversal submarine canyons

The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients

Purposes: Most molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches. Patients and Methods: We collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes. Results: PAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors. Conclusions: This is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America. Clinical Trial Registration: ClinicalTrials.gov (Identifier: NCT02326857).Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Abdelhay, Eliana Saul Furquim Werneck. Instituto Nacional de Cancer; BrasilFil: Artagaveytia, Nora. Universidad de la Republica; UruguayFil: Daneri Navarro, Adrián. Universidad de Guadalajara; MéxicoFil: Müller, Bettina. Instituto Nacional del Cáncer; ChileFil: Velazquez, Carlos. Universidad de Sonora; MéxicoFil: Alcoba, Elsa B.. Hospital Maria Curie; ArgentinaFil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; UruguayFil: Alves Da Quinta, Daniela Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Argentina de la Empresa; ArgentinaFil: Binato, Renata. Instituto Nacional de Cancer; BrasilFil: Bravo, Alicia Inés. Hospital Regional de Agudos Eva Perón; ArgentinaFil: Camejo, Natalia. Universidad de la Republica; UruguayFil: Carraro, Dirce Maria. Centro Internacional de Pesquisa; BrasilFil: Castro, Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Castro Cervantes, Juan M.. Umae Hospital de Especialidades Centro Medico Nacional Siglo XXI; MéxicoFil: Cataldi, Sandra. Instituto Nacional del Cáncer; UruguayFil: Cayota, Alfonso. Instituto Pasteur de Montevideo; UruguayFil: Cerda, Mauricio. Universidad de Chile; ChileFil: Colombo, Alicia. Universidad de Chile; ChileFil: Crocamo, Susanne. National Cancer Institute; Estados UnidosFil: Del Toro Arreola, Alicia. Universidad de Guadalajara; MéxicoFil: Delgadillo Cisterna, Raúl. Umae Hospital de Especialidades Centro Medico Nacional Siglo Xxi; MéxicoFil: Delgado, Lucía. Universidad de la Republica; UruguayFil: Fernandez, Elmer Andres. Area de Cs. Agrarias, Ingeniería, Cs. Biológicas y de la Salud de la Universidad Catollica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Fejerman, Laura. University of California at Davis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Trinchero, Alejandra. Hospital Regional de Agudos Eva Perón; ArgentinaFil: Valenzuela, Olivia. Universidad de Sonora; MéxicoFil: Vedham, Vidya. National Cancer Institute; Estados UnidosFil: Zagame, Livia. Instituto Jalisciense de Cancerología; MéxicoFil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

Hypertension in the very old; prevalence, awareness, treatment and control: a cross-sectional population-based study in a Spanish municipality

<p>Abstract</p> <p>Background</p> <p>Information on hypertension in the very elderly is sparse. Until recently evidence of benefits from pharmacological treatment was inconclusive. We estimated the prevalence of hypertension in subjects aged 80 or more, the proportion of awareness, treatment and control. Explanatory variables associated with good control were also studied.</p> <p>Methods</p> <p>Cross sectional, population-based study, conducted in Martorell, an urban Spanish municipality, in 2005. By simple random sampling from the census, 323 subjects aged 80 or more were included. Patients were visited at home or in the geriatric institution and after giving informed consent, the study variables were collected. These included: supine and standing blood pressure and information about diagnosis and treatment of hypertension. The estimation and 95% confidence interval were obtained and a logistic regression model was used to study explanatory variables associated with blood pressure below 140/90 mm Hg.</p> <p>Results</p> <p>The prevalence of hypertension was 72.8% (95%CI: 69.5 – 76.6%) and 93% of the patients were aware of this condition, of whom 96.3% (95%CI: 93.65 – 97.9%) had been prescribed pharmacological treatment and 30.7% (95%CI: 25.8 – 36.1%) had blood pressure below 140/90 mm Hg. Some of the patients (43%) had one antihypertensive drug and 39.5% had two in combination. Explanatory variables associated with blood pressure below 140/90 mm Hg included prescription of a diuretic, OR: 0.31 (95%CI: 0.14 – 0.66), and history of ischemic heart disease, OR: 0.21 (95%CI: 0.1 – 0.47).</p> <p>Conclusion</p> <p>The prevalence of hypertension in population aged 80 or more was over 70%. Most patients were aware of this condition and they had antihypertensive medication prescribed. Approximately one third of treated patients had blood pressure below 140/90 mm Hg. Patients with heart disease and with diuretics had more frequently blood pressure below this value.</p

Epidemiology, Molecular Characterization and Antibiotic Resistance of Neisseria meningitidis from Patients ≤15 Years in Manhiça, Rural Mozambique

BACKGROUND: The epidemiology of meningococcal disease in Mozambique and other African countries located outside the "meningitis belt" remains widely unknown. With the event of upcoming vaccines microbiological and epidemiological information is urgently needed. METHODS: Prospective surveillance for invasive bacterial infections was conducted at the Manhiça District hospital (rural Mozambique) among hospitalized children below 15 years of age. Available Neisseria meningitidis isolates were serogrouped and characterized by Multilocus Sequence Typing (MLST). Antibiotic resistance was also determined. RESULTS: Between 1998 and 2008, sixty-three cases of confirmed meningococcal disease (36 meningitis, 26 sepsis and 1 conjunctivitis) were identified among hospitalized children. The average incidence rate of meningococcal disease was 11.6/100,000 (8/100,000 for meningitis and 3.7/100,000 for meningococcemia, respectively). There was a significant rise on the number of meningococcal disease cases in 2005-2006 that was sustained till the end of the surveillance period. Serogroup was determined for 43 of the 63 meningococcal disease cases: 38 serogroup W-135, 3 serogroup A and 2 serogroup Y. ST-11 was the most predominant sequence type and strongly associated with serogroup W-135. Two of the three serogroup A isolates were ST-1, and both serogroup Y isolates were ST-175. N. meningitidis remained highly susceptible to all antibiotics used for treatment in the country, although the presence of isolates presenting intermediate resistance to penicillin advocates for continued surveillance. CONCLUSIONS: Our data show a high rate of meningococcal disease in Manhiça, Mozambique, mainly caused by serogroup W-135 ST-11 strains, and advocates for the implementation of a vaccination strategy covering serogroup W-135 meningococci in the country

La Cueva de El Sidrón (Piloña Asturias)

Estado de las excavaciones y estudios en la Cueva de El Sidrón (PIloña, Asturias)

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Modern humans have populated Europe for more than 45,000 years. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants.Open access funding provided by Max Planck Society. This project has received funding by the European Research Council under the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 803147-RESOLUTION (to S.T.), no. 771234-PALEoRIDER (to W.H.), no. 864358 (to K.M.), no. 724703 and no. 101019659 (to K.H.). K.H. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). E.A. has received funding from the Van de Kamp fonds. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeaux’s IdEx Investments for the Future programme/GPR Human Past. A.G.-O. is supported by a Ramón y Cajal fellowship (RYC-2017-22558). L. Sineo, M.L. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. C.L.S. and T. Saupe received support from the European Union through the European Regional Development Fund (project no. 2014-2020.4.01.16-0030) and C.L.S. received support from the Estonian Research Council grant PUT (PRG243). S. Shnaider received support from the Russian Science Foundation (no. 19-78-10053).Peer reviewe