FINDCHIRP: an algorithm for detection of gravitational waves from inspiraling compact binaries

Matched-filter searches for gravitational waves from coalescing compact binaries by the LIGO Scientific Collaboration use the FINDCHIRP algorithm: an implementation of the optimal filter with innovations to account for unknown signal parameters and to improve performance on detector data that has nonstationary and non-Gaussian artifacts. We provide details on the FINDCHIRP algorithm as used in the search for subsolar mass binaries, binary neutron stars, neutron star-black hole binaries, and binary black holes.Comment: 19 pages, 1 figure, journal version with Creative Commons 4.0 open-access license adde

Trauma histories of men and women in residential drug treatment: The Scottish evidence

This article focuses on self-reported child neglect and abuse in residential drug treatment drawing on data from clients in Scotland collected 1996-1999. It notes the lack of adoption of regular screening using validated tools of childhood trauma in men and women. The authors’ findings suggest that the prevalence of childhood abuse histories are higher in female drug users than male drug users but recognises that even with standardised tools there is a wealth of diverse categories of severity of abuse that warn against broad treatment plans for ‘the traumatised’

Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda

This paper was one of four papers commissioned to review the role of social sciences in NTD control by TDR, the Special Programme for Research and Training on Tropical Diseases, which is executed by WHO and co-sponsored by UNICEF, UNDP, the World Bank and WHO.This article has been made available through the Brunel Open Access Publishing Fund.Background: Less is known about mass drug administration [MDA] for neglected tropical diseases [NTDs] than is suggested by those so vigorously promoting expansion of the approach. This paper fills an important gap: it draws upon local level research to examine the roll out of treatment for two NTDs, schistosomiasis and soil-transmitted helminths, in Uganda. Methods: Ethnographic research was undertaken over a period of four years between 2005-2009 in north-west and south-east Uganda. In addition to participant observation, survey data recording self-reported take-up of drugs for schistosomiasis, soil-transmitted helminths and, where relevant, lymphatic filariasis and onchocerciasis was collected from a random sample of at least 10% of households at study locations. Data recording the take-up of drugs in Ministry of Health registers for NTDs were analysed in the light of these ethnographic and social survey data. Results: The comparative analysis of the take-up of drugs among adults revealed that although most long term residents have been offered treatment at least once since 2004, the actual take up of drugs for schistosomiasis and soil-transmitted helminths varies considerably from one district to another and often also within districts. The specific reasons why MDA succeeds in some locations and falters in others relates to local dynamics. Issues such as population movement across borders, changing food supply, relations between drug distributors and targeted groups, rumours and conspiracy theories about the 'real' purpose of treatment, subjective experiences of side effects from treatment, alternative understandings of affliction, responses to social control measures and historical experiences of public health control measures, can all make a huge difference. The paper highlights the need to adapt MDA to local circumstances. It also points to specific generalisable issues, notably with respect to health education, drug distribution and more effective use of existing public health legislation. Conclusion: While it has been an achievement to have offered free drugs to so many adults, current standard practices of monitoring, evaluation and delivery of MDA for NTDs are inconsistent and inadequate. Efforts to integrate programmes have exacerbated the difficulties. Improved assessment of what is really happening on the ground will be an essential step in achieving long-term overall reduction of the NTD burden for impoverished communities.This article is available through the Brunel Open Access Publishing Fund

A coherent triggered search for single spin compact binary coalescences in gravitational wave data

In this paper we present a method for conducting a coherent search for single spin compact binary coalescences in gravitational wave data and compare this search to the existing coincidence method for single spin searches. We propose a method to characterize the regions of the parameter space where the single spin search, both coincident and coherent, will increase detection efficiency over the existing non-precessing search. We also show example results of the coherent search on a stretch of data from LIGO's fourth science run but note that a set of signal based vetoes will be needed before this search can be run to try to make detections.Comment: 14 pages, 4 figure

Radiative Falloff in Neutron Star Spacetimes

We systematically study late-time tails of scalar waves propagating in neutron star spacetimes. We consider uniform density neutron stars, for which the background spacetime is analytic and the compaction of the star can be varied continously between the Newtonian limit 2M/R << 1 and the relativistic Buchdahl limit 2M/R = 8/9. We study the reflection of a finite wave packet off neutron stars of different compactions 2M/R and find that a Newtonian, an intermediate, and a highly relativistic regime can be clearly distinguished. In the highly relativistic regime, the reflected signal is dominated by quasi-periodic peaks, which originate from the wave packet bouncing back and forth between the center of the star and the maximum of the background curvature potential at R ~ 3 M. Between these peaks, the field decays according to a power-law. In the Buchdahl limit 2M/R -> 8/9 the light travel time between the center and the maximum or the curvature potential grows without bound, so that the first peak arrives only at infinitely late time. The modes of neutron stars can therefore no longer be excited in the ultra-relativistic limit, and it is in this sense that the late-time radiative decay from neutron stars looses all its features and gives rise to power-law tails reminiscent of Schwarzschild black holes.Comment: 10 pages, 7 figures, to appear in PR

Influenza Vaccine Effectiveness against Hospitalisation with Confirmed Influenza in the 2010-11 Seasons: A Test-negative Observational Study

Immunisation programs are designed to reduce serious morbidity and mortality from influenza, but most evidence supporting the effectiveness of this intervention has focused on disease in the community or in primary care settings. We aimed to examine the effectiveness of influenza vaccination against hospitalisation with confirmed influenza. We compared influenza vaccination status in patients hospitalised with PCR-confirmed influenza with patients hospitalised with influenza-negative respiratory infections in an Australian sentinel surveillance system. Vaccine effectiveness was estimated from the odds ratio of vaccination in cases and controls. We performed both simple multivariate regression and a stratified analysis based on propensity score of vaccination. Vaccination status was ascertained in 333 of 598 patients with confirmed influenza and 785 of 1384 test-negative patients. Overall estimated crude vaccine effectiveness was 57% (41%, 68%). After adjusting for age, chronic comorbidities and pregnancy status, the estimated vaccine effectiveness was 37% (95% CI: 12%, 55%). In an analysis accounting for a propensity score for vaccination, the estimated vaccine effectiveness was 48.3% (95% CI: 30.0, 61.8%). Influenza vaccination was moderately protective against hospitalisation with influenza in the 2010 and 2011 seasons

High quality and quantity Genome-wide germline genotypes from FFPE normal tissue

<p>Abstract</p> <p>Background</p> <p>Although collections of formalin fixed paraffin embedded (FFPE) samples exist, sometimes representing decades of stored samples, they have not typically been utilized to their full potential. Normal tissue from such samples would be extremely valuable for generation of genotype data for individuals who cannot otherwise provide a DNA sample.</p> <p>Findings</p> <p>We extracted DNA from normal tissue identified in FFPE tissue blocks from prostate surgery and obtained complete genome wide genotype data for over 500,000 SNP markers for these samples, and for DNA extracted from whole blood for 2 of the cases, for comparison.</p> <p>Four of the five FFPE samples of varying age and amount of tissue had identifiable normal tissue. We obtained good quality genotype data for between 89 and 99% of all SNP markers for the 4 samples from FFPE. Concordance rates of over 99% were observed for the 2 samples with DNA from both FFPE and from whole blood.</p> <p>Conclusions</p> <p>DNA extracted from normal FFPE tissue provides excellent quality and quantity genome-wide genotyping data representing germline DNA, sufficient for both linkage and association analyses. This allows genetic analysis of informative individuals who are no longer available for sampling in genetic studies.</p

Search for Periodic Gravitational Wave Sources with the Explorer Detector

We have developped a procedure for the search of periodic signals in the data of gravitational wave detectors. We report here the analysis of one year of data from the resonant detector Explorer, searching for pulsars located in the Galactic Center (GC). No signals with amplitude greater than $\bar{h}= 2.9~10^{-24}$, in the range 921.32-921.38 Hz, were observed using data collected over a time period of 95.7 days, for a source located at $\alpha=17.70 \pm 0.01$ hours and $\delta=-29.00 \pm 0.05$ degrees. Our procedure can be extended for any assumed position in the sky and for a more general all-sky search, even with a frequency correction at the source due to the spin-down and Doppler effects.Comment: One zipped file (Latex+eps figures). 33 pages, 14 figures. This and related material also at http://grwav3.roma1.infn.it

Tracking spatial regimes in animal communities: Implications for resilience-based management

Spatial regimes (the spatial extents of ecological states) exhibit strong spatiotemporal order as they expand or contract in response to retreating or encroaching adjacent spatial regimes (e.g., woody plant invasion of grasslands) and human management (e.g., fire treatments). New methods enable tracking spatial regime boundaries via vegetation landcover data, and this approach is being used for strategic management across biomes. A clear advancement would be incorporating animal community data to track spatial regime boundaries alongside vegetation data. In a 41,170-hectare grassland experiencing woody plant encroachment, we test the utility of using animal community data to track spatial regimes via two hypotheses. (H1) Spatial regime boundaries identified via independent vegetation and animal datasets will exhibit spatial synchrony; specifically, grassland:woodland bird community boundaries will synchronize with grass:woody vegetation boundaries. (H2) Negative feedbacks will stabilize spatial regimes identified via animal data; specifically, frequent fire treatments will stabilize grassland bird community boundaries. We used 26 years of bird community and vegetation data alongside 32 years of fire history data. We identified spatial regime boundaries with bird community data via a wombling approach. We identified spatial regime boundaries with vegetation data by calculating spatial covariance between remotely-sensed grass and woody plant cover per pixel. For fire history data, we calculated the cumulative number of fires per pixel. Setting bird boundary strength (wombling R2 values) as the response variable, we tested our hypotheses with a hierarchical generalized additive model (HGAM). Both hypotheses were supported: animal boundaries synchronized with vegetation boundaries in space and time, and grassland bird communities stabilized as fire frequency increased (HGAM explained 38% of deviance). We can now track spatial regimes via animal community data pixel-by-pixel and year-by-year. Alongside vegetation boundary tracking, tracking animal community boundaries can inform the scale of management necessary to maintain animal communities endemic to desirable ecological states. Our approach will be especially useful for conserving animal communities requiring large-scale, unfragmented landscapes—like grasslands and steppes

Method to estimate ISCO and ring-down frequencies in binary systems and consequences for gravitational wave data analysis

Recent advances in the description of compact binary systems have produced gravitational waveforms that include inspiral, merger and ring-down phases. Comparing results from numerical simulations with those of post-Newtonian (PN), and related, expansions has provided motivation for employing PN waveforms in near merger epochs when searching for gravitational waves and has encouraged the development of analytic fits to full numerical waveforms. The models and simulations do not yet cover the full binary coalescence parameter space. For these yet un-simulated regions, data analysts can still conduct separate inspiral, merger and ring-down searches. Improved knowledge about the end of the inspiral phase, the beginning of the merger, and the ring-down frequencies could increase the efficiency of both coherent inspiral-merger-ring-down (IMR) searches and searches over each phase separately. Insight can be gained for all three cases through a recently presented theoretical calculation, which, corroborated by the numerical results, provides an implicit formula for the final spin of the merged black holes, accurate to within 10% over a large parameter space. Knowledge of the final spin allows one to predict the end of the inspiral phase and the quasinormal mode ring-down frequencies, and in turn provides information about the bandwidth and duration of the merger. In this work we will discuss a few of the implications of this calculation for data analysis.Comment: Added references to section 3 14 pages 5 figures. Submitted to Classical and Quantum Gravit