352 research outputs found
Developing a boundary object model to analyze communication interfaces : applications for system integrators
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2007.Includes bibliographical references (p. 131-133).Physical information is transferred between technical systems through wires, beams, and other physical attributes, while more intangible information is typically transferred between communities of people through artifacts such as documents, e-mails, etc. This research attempts to characterize these communication interfaces better by analyzing the use of artifacts at these interfaces by means of a boundary object attribute model. Boundary objects, the metric of analysis of this thesis, are artifacts used to bridge information and knowledge gaps between different communities of practice. The US Army's Future Combat System (FCS) was chosen as a case study primarily because of its complex programmatic characteristics. The information gathered in the FCS case study was combined with knowledge from previous boundary object literature to generate an attributes model. Once developed, the boundary object attributes model was validated on the US Air Force Transformational Communications Satellite System (TSAT) program focusing specifically on the TSAT Mission Operations System (TMOS) segment of the program. Data were collected on the frequency and type of resources used to understand information and the dependencies that individuals have with each other for documented information. Furthermore, five communication artifacts were critiqued for their effectiveness as boundary objects. Statistical tests were conducted to highlight trends in resource dependencies and attributes common in effective boundary objects. An implication of this research is that the most important attributes for a boundary object are inclusivity, traceability, and synchronization. This research also found that people generally tend to rely much more on other people for information than artifacts. This introduces problems of exhausting valuable human resources and creating unnecessary bottlenecks.(cont.) A second implication of this research is that spending the extra time and effort to design artifacts with high inclusivity and freshness will add significant value to the overall system. In addition, a third implication of this research is that having the right boundary objects alone is not enough for effective collaborative interfaces. A fourth implication of this research is that designing a boundary object whose form follows its function is critical for its effectiveness. These suggestions can provide relief to a program highly taxing to its human resources and reduce transaction costs of the overall system. Furthermore, this model may be extended for the purpose of determining the roles and responsibilities of system integrators.by Allan Fong.S.M
Using a Boundary Object Framework to Analyze Interorganizational Collaboration
The U.S. military is facing a plethora of challenges as a result of tightening procurement
budgets and the need to acquire new capabilities to operate in modern war environments. This
requires integrating legacy systems with developing technologies in what is loosely defined to be
a System of Systems. Most Systems of Systems require some integrator to manage and operate
the system interfaces. In addition to technical integration challenges, these system integrators
have the difficult undertaking of integrating various organizations. The boundary object
framework proposed by this paper provides a tool for systems integrators working in System of
Systems or any type of complex system to identify and categorize communication, coordination,
and collaboration interfaces and address possible failures
A Boundary Object Model to Analyze Communication Interfaces
Outline:
⢠Problem Statement
⢠Approach
⢠Boundary Object Example
⢠Previous Research Applications
⢠FCS Case Study
⢠Development of Boundary Object Framework
⢠TMOS Case Study
⢠Results
⢠Implications
⢠Recommendations
⢠ConclusionsThe Aerospace Corporatio
Boundary Objects as a Framework to Understand the Role of Systems Integrators
5th Annual Conference on Systems Engineering Research (CSER) presentatio
Surface Telerobotics: Development and Testing of a Crew Controlled Planetary Rover System
In planning for future exploration missions, architecture and study teams have made numerous assumptions about how crew can be telepresent on a planetary surface by remotely operating surface robots from space (i.e. from a flight vehicle or deep space habitat). These assumptions include estimates of technology maturity, existing technology gaps, and operational risks. These assumptions, however, have not been grounded by experimental data. Moreover, to date, no crew-controlled surface telerobot has been fully tested in a high-fidelity manner. To address these issues, we developed the "Surface Telerobotics" tests to do three things: 1) Demonstrate interactive crew control of a mobile surface telerobot in the presence of short communications delay. 2) Characterize a concept of operations for a single astronaut remotely operating a planetary rover with limited support from ground control. 3) Characterize system utilization and operator work-load for a single astronaut remotely operating a planetary rover with limited support from ground control
Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.
Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK
Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density
Our understanding of the pathogenesis of Paget's disease of the vulva and the breast remains limited. Current evidence supports the fact that angiogenesis plays an important role in the pathogenesis of several diseases. Therefore, we sought to define its role, as correlated with microvessel density, in Paget's disease of the vulva and the breast.
Microvessels were analysed using anti-von Willebrand factor antibody in 105 cases of Paget's disease of the vulva and the breast comprising 71 cases of Paget's disease of the vulva, including 8 cases with invasive disease, and 34 cases of Paget's disease of the breast. The latter included 12 cases with DCIS, 5 cases with both DCIS and invasive carcinoma, and 6 with carcinoma alone. Eleven cases had no underlying tumour identified. Increased microvessel density was demonstrated in Paget's disease of the breast with DCIS and with carcinoma alone compared to Paget's disease of the breast alone, P < 0.08 and P < 0.013, respectively. There were no significant differences in microvessel density in the vulval cases. Neovascularisation is an important process in the development of Paget's disease of the breast. Other biological and molecular processes are more involved in the pathogenesis of Paget's disease of the vulva
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