5 research outputs found

    A New Look at Old English Metrics

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    In this paper I propose a scansion of Old English alliterative poetry in terms of a binary branching template. The analysis builds on work by Halle and Keyser (1971) and Maling (1971), but has two advantages over these analyses: (a) it provides a natural explanation of many apparently irregular verses, and (b) it makes more accurate predictions of the relative frequencies of different verse types

    Automatic Extraction of Facts from Press Releases to Generate News Stories

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    While complete understanding of arbitrary input text remains in the future, it is currently possible to construct natural language processing systems that provide a partial understanding of text with limited accuracy. Moreover, such systems can provide cost-effective solutions to commercially-significant business problems. This paper describes one such system: JASPER. JASPER is a fact extraction system recently developed and deployed by Carnegie Group for Reuters Ltd. JASPER uses a template-driven approach, partial understanding techniques, and heuristic procedures to extract certain key pieces of information from a limited range of text., We believe that many significant business problems can be solved by fact extraction applications which involve locating and extracting specific, predefined types of information from a limited range of texL The information extracted by such systems can be used in a variety of ways, such as filling in values in a database, generating summaries of the input text, serving as a part of the knowledge in an expert system, or feeding into another program which bases decisions on it. We expect to develop many such applications in the future using similar techniques

    Penetrance and Expressivity of MSH6 Germline Mutations in Seven Kindreds Not Ascertained by Family History

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    Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by inherited mutations in DNA mismatch-repair genes, most commonly MLH1 or MSH2. The role MSH6 plays in inherited cancer susceptibility is less well defined. The aim of this study was to investigate the penetrance and expressivity of MSH6 mutations in kindreds ascertained through endometrial cancer probands unselected for family history. Detailed pedigrees were constructed for six MSH6 mutation carriers. All reported cancers and precancers were confirmed, and tissues were obtained when available. Tumors were analyzed for microsatellite instability (MSI) and for expression of MSH2, MLH1, and MSH6. MSH6 mutation status was determined for 59 family members. Of these 59 individuals, 19 (32%) had confirmed cancers and precancers. There was an excess of mutation carriers among the 19 affected family members (11 [58%] of 19) compared with those among the 40 unaffecteds (8 [20%] of 40, P=.0065, odds ratio = 5.5, 95% CI = 1.66–18.19). In four of the seven tumors analyzed from mutation carriers other than the probands, MSI and/or MMR protein expression was consistent with the involvement of MSH6. Overall estimated penetrance of the MHS6 mutations was 57.7%. Of the tumors in mutation carriers, 78% were part of the extended HNPCC spectrum. This study demonstrates that MSH6 germline mutations are, indeed, associated with increased cancer risk and that the penetrance of mutations may be higher than appreciated elsewhere. A combination of MSI and immunohistochemistry analyses may be helpful in screening for MSH6 mutation carriers
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