2 research outputs found

    Superimposed hazard ratios for subgroups of patients treated with amiodarone or a defibrillator, compared to the common control in SCD-HeFT

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    The figure was created by superimposing the hazard ratios with confidence intervals reported in SCD-HeFT from the left portion of Figure 5 (depicting amiodarone versus placebo) upon those on the right (defibrillator therapy versus placebo) as shown in the circular inset (see text for specific construction). Dots with solid (or dashed) horizontal lines represent the hazard ratio and confidence intervals for the effect of treatment with a defibrillator (or amiodarone) versus the common control on outcome. The vertical dotted line represents the alignment of the hazard ratios for the topmost subgroup defined by each variable. Subgroups with discordant treatment effects are highlighted as green text. Abbreviations: ft = feet; LVEF = left ventricular ejection fraction. (Copyright 2005, Massachusetts Medical Society [5]. All rights reserved. Adapted with permission.).<p><b>Copyright information:</b></p><p>Taken from "Pearls and perils of an implantable defibrillator trial using a common control: implications for the design of future studies"</p><p>http://www.trialsjournal.com/content/9/1/24</p><p>Trials 2008;9():24-24.</p><p>Published online 2 May 2008</p><p>PMCID:PMC2397377.</p><p></p

    Depiction of a trial using a common control design testing the same clinical question as one with 2 separate controls (shown in figure 1)

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    The corresponding study-wide alpha (α) and beta (β) calculations are depicted below the design. The designated relative samples sizes are those for maximum efficiency. In the common control design shown, the active treatments of amiodarone and a defibrillator are compared against a common control, which is administered an oral placebo. The most efficient allocation of patients to these treatments and the common control is in the ratio of 1:1:√2.<p><b>Copyright information:</b></p><p>Taken from "Pearls and perils of an implantable defibrillator trial using a common control: implications for the design of future studies"</p><p>http://www.trialsjournal.com/content/9/1/24</p><p>Trials 2008;9():24-24.</p><p>Published online 2 May 2008</p><p>PMCID:PMC2397377.</p><p></p
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