Characteristics of the three samples of European-Americans and two samples of African-Americans.

<p>*TG units: ARIC—mmol/L; FRAM—Meq/L; MESA—mg/dL</p><p>**HDL units: ARIC—mmol/L; FRAM & MESA—mg/dL</p><p>Characteristics of the three samples of European-Americans and two samples of African-Americans.</p

Association of TG GRS with incident T2D and interaction of TG with TG GRS on incident T2D in each dataset and in EA (top; n = 13,247) and AA (bottom; n = 3,238).

<p>Hazard ratios and 95% CI are shown. Covariates include age, sex, BMI, TG, and HDL.</p

Association of TG with T2D in each of three strata of TG GRS, in EA and AA.

<p>Hazard ratios and 95% CI are shown. Covariates include age, sex, BMI, TG, and HDL.</p

List of 31 triglyceride (TG)-associated SNPs with their respective genomic position, risk allele (TG increasing), TG effect size (weight used in GRS), association with T2D incidence, and interaction with TG phenotype in European- and African-Americans (EA, AA).

<p>Covariates include age, sex, BMI, TG, and HDL.</p><p>List of 31 triglyceride (TG)-associated SNPs with their respective genomic position, risk allele (TG increasing), TG effect size (weight used in GRS), association with T2D incidence, and interaction with TG phenotype in European- and African-Americans (EA, AA).</p

Classification trees identifying profiles of participants who gained ≥3% weight between baseline and the third annual visit in participants, stratified by race (African American women versus white women).

<p>(* indicates that due to small sample size, odds ratio and 95% confidence interval could not be converted; CI, confidence interval; OR, odds ratio) <b><i>A</i></b>: African American women. <b><i>B</i></b>: White women.</p

Stepwise logistic regression odds ratios of 3% or more weight gain, stratified by race (African Americans vs. whites) in participants enrolled in an ancillary study of the Women’s Health Initiative Observational Study at Baylor College of Medicine and Wake Forest School of Medicine between February 1995 and July 1998.

<p>CI, confidence interval; BMI, body mass index.</p><p>* In the analysis for African American women, due to scanty sample size, a lifetime partner variable was excluded.</p><p>^† Weight-change was assessed at the third annual visit.</p><p>** Intentional weight loss of more than 10 pounds was examined within the past 20 years, when participants were not pregnant or sick.</p><p>Stepwise logistic regression odds ratios of 3% or more weight gain, stratified by race (African Americans vs. whites) in participants enrolled in an ancillary study of the Women’s Health Initiative Observational Study at Baylor College of Medicine and Wake Forest School of Medicine between February 1995 and July 1998.</p

Classification trees identifying profiles of participants who gained ≥3% weight between baseline and the third annual visit in participants, stratified by age (< 65 versus ≥65 years).

<p>(CI, confidence interval; OR, odds ratio) <b><i>A</i></b>: Participants < 65 years. <b><i>B</i></b>: Participants ≥65 years.</p

ApoE genotypes by LRP-1 <i>I10701</i> genotype.

<p>ApoE genotypes by LRP-1 <i><u>I10701</u></i> genotype.</p

N, mean age (standard deviation) and percentage of males and ApoE ε3 carriers, in the GOLDN study population by LRP-1 genotype group.

†<p>a = minor allele; A = major allele.</p>‡<p><i>P</i>-values were derived from tests of null hypothesis that no group is different, using a 1-way ANOVA for continuous traits or the χ² test for categorical variables.</p

Parameter estimates from linear regression models looking at the effects of <i>LRP-1</i> I10701 SNP and <i>ApoE</i> isoforms on BMI in the GOLDN study population.

a<p><i>P</i>-values were derived from mixed linear models, specifying a Kenward Rogers correction on the estimator, with <i>LRP-1</i> I10701 SNP and <i>ApoE</i> genotype frequency, an interaction between ApoE and LRP-1 genotype frequency, age and age², sex, smoking, total alcohol and center of data collection as predictors, and BMI (logarithmically transformed) as the outcome.</p