INDIVIDUAL CAREER IN THE CURRENT ECONOMIC CRISIS

Human resources represent the creative, active and coordinating element of the organisational activity, having a strong influence on the efficiency of the use of material, financial and information resources. The description of people as ”resources” highlights their importance and shows that their management requires high levels of genuine care and attention to people and professionalism. 2010 and 2011 are very difficult years for those who want to find a job. Flexibility and a decent salary are the reference words. The economy in a turbulent situation does not guarantee the safety of the jobs. The university graduates must make efforts and prove to have communication skills in order to obtain or keep the desired position. Our paper focusses on the aspects of career development for the young university graduates, thus treating a subject of wide interest these days.job, career development, flexibility, university graduates labour force

On a singular Riemann–Liouville fractional boundary value problem with parameters

We investigate the existence of positive solutions for a nonlinear Riemann–Liouville fractional differential equation with a positive parameter subject to nonlocal boundary conditions, which contain fractional derivatives and Riemann–Stieltjes integrals. The nonlinearity of the equation is nonnegative, and it may have singularities at its variables. In the proof of the main results, we use the fixed point index theory and the principal characteristic value of an associated linear operator. A related semipositone problem is also studied by using the Guo–Krasnosel’skii fixed point theorem

Cyclotomic coefficients: gaps and jumps

We improve several recent results by Hong, Lee, Lee and Park (2012) on gaps and Bzd\c{e}ga (2014) on jumps amongst the coefficients of cyclotomic polynomials. Besides direct improvements, we also introduce several new techniques that have never been used in this area.Comment: 25 page

Heat systems of the glass house

This paper deals with a series of problems regarding analysis, evaluation and improvement of the performance of heat installation of the complex functional glass house. Design and execution of this type of constructions must take into account a number of important factors for providing thermal comfort. Due to their architectural structure, constructive and functional, glass house impose some conditions for an optimal and economic system for heating and air - conditioning. Our case study put an emphasis on the specific problems of analysis and their solutions for a new glass house

Unconventional Non-Invasive Diagnostic Techniques and Treatment of White Spot Lesions in Paediatric Dentistry and Orthodontics

Minimal Intervention Dentistry (MID), a concept that aims to minimize the interventional procedures applied on teeth affected by dental caries, emphasizes the importance of prevention and detection of lesions in early stage. The white spot lesion (WSL) is the first visible stage of the carious process, affecting the enamel. Their detection and treatment has been significantly improved in the last decade through new technology available. Our paper describes a non-invasive detection method, using a lighttransmission device (transillumination of the teeth using Diagnocam, by Kavo) , combined with a resin infiltration technique (using Icon, by DMG) of the WSL

Identification of biomarkers for the management of human prostate cancer

A critical problem in the clinical management of prostate cancer is that it shows high intra- and inter-tumoural heterogeneity. As a result, accurate prediction of individual cancer behaviour is not achievable at the time of diagnosis, leading to substantial overtreatment. It remains an enigma that, in contrast to other cancers, no molecular biomarkers which define robust subtypes of prostate cancer with distinct clinical outcomes have been discovered. In the first part of this study, using data from exon microarrays, we developed a novel method that can identify transcriptional alterations within genes. The alterations might be the result of chromosomal rearrangements, such as translocations, and deletions, or of other abnormalities, such as read-through transcription and alternative transcriptional initiation sites. Using data from two independent datasets we identify several candidate alterations that are constantly correlated with the biochemical failure or that are linked to the development of metastasis. In the second part of the study we illustrate the application of an unsupervised Bayesian procedure, which identifies a subtype of the disease in five prostate cancer transcriptome datasets. Cancers assigned to this subtype (designated DESNT cancers) are characterized by low expression of a core set of 45 genes. For the four datasets with linked PSA failure data following prostatectomy, patients with DESNT cancer exhibited poor outcome relative to other patients (p = 2.65 ・ 10−5, p = 4.28 ・ 10−5, p = 2.98 ・ 10−8 and p = 1.22 ・ 10−3). The DESNT cancers are not linked with the presence of any particular class of genetic mutation, including ETS gene status. However, the methylation analysis reveals a possible role of epigenetic changes in the generation of the DESNT subtype. Our results demonstrate the existence of a novel poor prognosis category of human prostate cancer and will assist in the targeting of therapy, helping avoid treatment-associated morbidity in men with indolent disease