2,002 research outputs found
INDIVIDUAL CAREER IN THE CURRENT ECONOMIC CRISIS
Human resources represent the creative, active and coordinating element of the organisational activity, having a strong influence on the efficiency of the use of material, financial and information resources. The description of people as âresourcesâ highlights their importance and shows that their management requires high levels of genuine care and attention to people and professionalism. 2010 and 2011 are very difficult years for those who want to find a job. Flexibility and a decent salary are the reference words. The economy in a turbulent situation does not guarantee the safety of the jobs. The university graduates must make efforts and prove to have communication skills in order to obtain or keep the desired position. Our paper focusses on the aspects of career development for the young university graduates, thus treating a subject of wide interest these days.job, career development, flexibility, university graduates labour force
On a singular RiemannâLiouville fractional boundary value problem with parameters
We investigate the existence of positive solutions for a nonlinear RiemannâLiouville fractional differential equation with a positive parameter subject to nonlocal boundary conditions, which contain fractional derivatives and RiemannâStieltjes integrals. The nonlinearity of the equation is nonnegative, and it may have singularities at its variables. In the proof of the main results, we use the fixed point index theory and the principal characteristic value of an associated linear operator. A related semipositone problem is also studied by using the GuoâKrasnoselâskii fixed point theorem
Cyclotomic coefficients: gaps and jumps
We improve several recent results by Hong, Lee, Lee and Park (2012) on gaps
and Bzd\c{e}ga (2014) on jumps amongst the coefficients of cyclotomic
polynomials. Besides direct improvements, we also introduce several new
techniques that have never been used in this area.Comment: 25 page
Heat systems of the glass house
This paper deals with a series of problems regarding analysis, evaluation and improvement of the performance of heat
installation of the complex functional glass house. Design and execution of this type of constructions must take into
account a number of important factors for providing thermal comfort. Due to their architectural structure, constructive
and functional, glass house impose some conditions for an optimal and economic system for heating and air -
conditioning. Our case study put an emphasis on the specific problems of analysis and their solutions for a new glass
house
Unconventional Non-Invasive Diagnostic Techniques and Treatment of White Spot Lesions in Paediatric Dentistry and Orthodontics
Minimal Intervention Dentistry (MID), a concept that aims to minimize the interventional procedures applied on teeth affected by dental caries, emphasizes the importance of prevention and detection of lesions in early stage. The white spot lesion (WSL) is the first visible stage of the carious process, affecting the enamel. Their detection and treatment has been significantly improved in the last decade through new technology available. Our paper describes a non-invasive detection method, using a lighttransmission device (transillumination of the teeth using Diagnocam, by Kavo) , combined with a resin infiltration technique (using Icon, by DMG) of the WSL
Identification of biomarkers for the management of human prostate cancer
A critical problem in the clinical management of prostate cancer is that it shows high
intra- and inter-tumoural heterogeneity. As a result, accurate prediction of individual
cancer behaviour is not achievable at the time of diagnosis, leading to substantial
overtreatment. It remains an enigma that, in contrast to other cancers, no molecular
biomarkers which define robust subtypes of prostate cancer with distinct clinical
outcomes have been discovered.
In the first part of this study, using data from exon microarrays, we developed a novel
method that can identify transcriptional alterations within genes. The alterations might
be the result of chromosomal rearrangements, such as translocations, and deletions, or
of other abnormalities, such as read-through transcription and alternative transcriptional
initiation sites. Using data from two independent datasets we identify several candidate
alterations that are constantly correlated with the biochemical failure or that are linked
to the development of metastasis.
In the second part of the study we illustrate the application of an unsupervised
Bayesian procedure, which identifies a subtype of the disease in five prostate cancer
transcriptome datasets. Cancers assigned to this subtype (designated DESNT cancers)
are characterized by low expression of a core set of 45 genes. For the four datasets
with linked PSA failure data following prostatectomy, patients with DESNT cancer
exhibited poor outcome relative to other patients (p = 2.65 ă» 10â5, p = 4.28 ă» 10â5, p =
2.98 ă» 10â8 and p = 1.22 ă» 10â3). The DESNT cancers are not linked with the presence
of any particular class of genetic mutation, including ETS gene status. However, the
methylation analysis reveals a possible role of epigenetic changes in the generation of
the DESNT subtype. Our results demonstrate the existence of a novel poor prognosis
category of human prostate cancer and will assist in the targeting of therapy, helping
avoid treatment-associated morbidity in men with indolent disease
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