263 research outputs found

    Experimental techniques for the study of natural photonic structures

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    This thesis presents a study into structural colours that exist in natural samples, the principle aim of which is to produce experimental methods by which these colours may be examined and evaluated. In order to achieve this, previously observed structures are described, electromagnetic theory is summarised and a series of samples are examined constituting examples of the structures present in nature. The first sample discussed is the multilayer in the epicuticle of the buprestid beetle, C. raja. In order to evaluate the refractive indices of the layers contained within this structure, existing optical techniques are used to establish absolute reflection spectra for a number of angles of incidence in both linear polarisations. The approximate design for the structure is obtained by electron microscopy and modelled using Fresnel's equations. This model is then refined by a recursive least squares fitting routine to obtain the refractive indices. The second sample is the diffuse white scattering structure in the scales of two white beetles, Lepidiota stigma and Cyphochilus spp.. The reflection from these scales is measured and found to be brilliantly white due to the irregular internal structure of the scales. Comparison of the Fast Fourier Transforms of TEM images of the internal structure with the diffraction pattern obtained from monochromatic laser light diffracting through a single scale demonstrate a link between this structure and photonic effects. The third sample type are found in the scales of the large true weevils, Eupholus schoenherri pettiti and E. magnificus. These scales are shown to have a domained structure in which the domains were oriented differently to each other. Single domains are shown to exhibit different colours at different orientation. The final sample is the highly regular 2-dimensional diffraction grating observed in a marine diatom, Coscinodiscus wailesii. Diffraction is demonstrated by measuring the in-plane diffraction from a single frustule for both monochromatic laser light and white light, showing an enhanced transmission for red wavelengths. Subsequent imaging of the transmitted diffraction pattern allows for the calculation of the transmitted power in each diffracted order.Engineering and Physical Sciences Research Council (EPSRC

    Gambia’s longtime dictator isn’t going anywhere any time soon

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    Jeffrey Smith and Alexander Noyes look at how failed coup attempts in the Gambia are leading to a more repressive regime in the West African country

    Experimental method for reliably establishing the refractive index of buprestid beetle exocuticle

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    Copyright © 2007 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-7-4351 . Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.In this study we apply an existing optical characterisation technique to establish reliably the complex refractive indices of layers comprising a natural multilayer reflector in the beetle Chrysochroa raja. Its reflector characteristics, ultrastructure and layer thicknesses were established using electron and optical microscopy. We recorded a significant number of wavelength dependent optical data sets from the same regions of sample using both linear polarisations and from a variety of different angles. These optical data sets were modelled simultaneously in order to significantly reduce the degeneracy of the fitting process. For the C. raja sample in question, the fitted complex refractive indices of both layer types were determined to be n=1.68 k=0.03 and n=1.55 k=0.14

    The Banks and the Panic of 1893

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    Precision medicine and adverse drug reactions related to cardiovascular drugs

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    Cardiovascular disease remains the leading global cause of death. Early intervention, with lifestyle advice alongside appropriate medical therapies, is fundamental to reduce patient mortality among high-risk individuals. For those who live with the daily challenges of cardiovascular disease, pharmacological management aims to relieve symptoms and prevent disease progression. Despite best efforts, prescription drugs are not without their adverse effects, which can cause significant patient morbidity and consequential economic burden for healthcare systems. Patients with cardiovascular diseases are often among the most vulnerable to adverse drug reactions due to multiple co-morbidities and advanced age. Examining a patient’s genome to assess for variants that may alter drug efficacy and susceptibility to adverse reactions underpins pharmacogenomics. This strategy is increasingly being implemented in clinical cardiology to tailor patient therapies. The identification of specific variants associated with adverse drug effects aims to predict those at greatest risk of harm, allowing alternative therapies to be given. This review will explore current guidance available for pharmacogenomic-based prescribing as well as exploring the potential implementation of genetic risk scores to tailor treatment. The benefits of large databases and electronic health records will be discussed to help facilitate the integration of pharmacogenomics into primary care, the heartland of prescribing
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