Rough interfaces, accurate predictions: The necessity of capillary modes in a minimal model of nanoscale hydrophobic solvation

Modern theories of the hydrophobic effect highlight its dependence on length scale, emphasizing in particular the importance of interfaces that emerge in the vicinity of sizable hydrophobes. We recently showed that a faithful treatment of such nanoscale interfaces requires careful attention to the statistics of capillary waves, with significant quantitative implications for the calculation of solvation thermodynamics. Here we show that a coarse-grained lattice model in the spirit of those pioneered by Chandler and coworkers, when informed by this understanding, can capture a broad range of hydrophobic behaviors with striking accuracy. Specifically, we calculate probability distributions for microscopic density fluctuations that agree very well with results of atomistic simulations, even many standard deviations from the mean, and even for probe volumes in highly heterogeneous environments. This accuracy is achieved without adjustment of free parameters, as the model is fully specified by well-known properties of liquid water. As illustrative examples of its utility, we characterize the free energy profile for a solute crossing the air-water interface, and compute the thermodynamic cost of evacuating the space between extended nanoscale surfaces. Together, these calculations suggest that a highly reduced model for aqueous solvation can serve as the basis for efficient multiscale modeling of spatial organization driven by hydrophobic and interfacial forces.Comment: 14 pages, 7 figure

Salvaging the Style of Frei Aber Einsam in the music of Brahms: Proposing a Historically Informed Performance Practice for the Three Sonatas for Violin and Piano of Johannes Brahms, Opp. 78, 100, and 108

This thesis explores scholarship relevant to assembling a historically informed performance practice of Brahms’s three Violin Sonatas, Opp. 78, 100, and 108 in the nineteenth-century Germanic violin tradition of which, Joseph Joachim was its greatest proponent. This inquiry, which primarily examines surviving evidence of Joachim, his pedagogical ilk, and the circle of Brahms, engages with a variety of 19th and early 20th century Germanic musical and textual evidence, including nineteenth-century musical editions, correspondence and other archival materials, and early recorded performances to propose a historically informed style. In presenting this historiography of materials relevant to forming a historically informed interpretation of these sonatas as well as presenting lacunae in the field, the value of this endeavor becomes evident

Adaptive and maladaptive motivational responses in online learners

The speed at which on-line technologies are being adopted in the learning of English as a second or foreign language creates an urgent need to establish links between theoretical positions and professional practice in the digital realm. As far as issues in motivation studies are concerned, much of what is known about the way learners of English behave is classroom and print-based and may not illuminate operational matters on-line to their fullest extent. This thesis describes the trial of English academic reading skills materials designed for Chinese scholars attending a tertiary-level Institution overseas and attempts to Identify and understand the variables that affected their performance on-line. The data collected from both quantitative and qualitative sources were considered within a framework that Identifies distinct patterns of behaviour, classified either as adaptive or maladaptive, Insofar as they affect the ways learners use their talents In the classroom. Analysis of the data showed that some participants seemed to obstruct their own learning on-line through their negative affective responses to the technology, materials and pedagogy used on the course. Others were able to achieve to a certain extent personally challenging and valued achievement goals. The data also highlighted challenges facing language tutors on-line In relationship building, fostering reflective practice and promoting Independence, and self-direction. Such areas of research are considered to be of particular value to practitioners who work In on-line contexts and have difficulty In Identifying and managing the dynamics of the environment they are involved in. Several implications are drawn from this study concerning the exploitation of online learning environments with Chinese students. Chief among these concerns the claim that cultural factors have a powerful Influence on the manner in which these students study and react on-line. In particular, Issues of 'face-management' and the operation of the 'self-worth motive' are highlighted and commented upon

When Party Does Not Matter: An Examination of Conditions that Influence a Senator to Vote Against Party Leadership

The United States Senate as the upper chamber of the United States Congress possesses great power and responsibility. The way that the 100 men and women who make up the chamber vote has long been of importance to those of us in the field of political science. This paper will look at influences that affect a senator’s decision to vote against leadership. The research will test these influences simultaneously in order to find the degrees of influence each has. The research will focus on the Senate from 1994 – 2008, when the Gingrich senators led to an increasingly polarized body but Citizens United had not yet changed the rules of campaigning

Myf5 Does not Induce Apoptosis in Skeletal Myoblasts but is Regulated by Oncogenic Ras Expression

Skeletal myogenesis is initiated by a family of muscle regulatory factors (MRFs) composed of the transcription factors MyoD, Myf5, MRF4, and myogenin. Of these, MyoD was the first discovered, is the most studied, and plays a well-characterized role in skeletal myoblast determination and differentiation. Our laboratory has also discovered that MyoD plays an important role in the apoptotic process that occurs in a subpopulation of myoblasts induced to differentiate. Expression of oncogenic Ras is known to inhibit myoblast differentiation and to decrease the expression of MyoD mRNA and protein. Our laboratory was the first to report that expression of oncogenic Ras also blocks the apoptotic process. While it is well known that MyoD and Myf5 function somewhat redundantly with respect to their role in the differentiation process, neither the role of Myf5 in the apoptotic process nor the regulation of Myf5 by oncogenic Ras has been investigated. Herein we report that, unlike MyoD, Myf5 is not sufficient to induce apoptosis. Further, like MyoD, Myf5 expression is decreased in both myoblasts and fibroblasts expressing oncogenic Ras. Additionally, we report that the mechanism of this inhibition is not a consequence of reducing Myf5 mRNA level

COMPACT VISION SYSTEM FOR MONITORING OF 3D WELD POOL SURFACE IN PIPE WELDING

Human welders have long been able to monitor a weld pool and adjust welding parameters accordingly. Automated welding robots can provide consistent movement during the welding process, but lack the ability to monitor the weld pool. A vision system attached to the welding robot could provide a way to monitor the weld pool substantially faster than a human being. Previous vision systems to monitor weld pool surfaces have been developed, but their uses are limited since the system is fixed in place. The compact vision system developed in this research attaches directly to the welding torch, which provides no limitations in weld pool monitoring. This system takes advantage of the specular surface of a molten weld pool by reflecting a pattern of laser beams from the weld pool surface. The deformation of the laser beam after it reflects from the weld pool surface can provide clues to the weld pool shape, and thus the penetration of the weld. Image processing techniques and geometric optics are used to reconstruct a weld pool surface shape based on the image captured of the deformed laser pattern

Myf5 Does not Induce Apoptosis in Skeletal Myoblasts but is Regulated by Oncogenic Ras Expression

Skeletal myogenesis is initiated by a family of muscle regulatory factors (MRFs) composed of the transcription factors MyoD, Myf5, MRF4, and myogenin. Of these, MyoD was the first discovered, is the most studied, and plays a well-characterized role in skeletal myoblast determination and differentiation. Our laboratory has also discovered that MyoD plays an important role in the apoptotic process that occurs in a subpopulation of myoblasts induced to differentiate. Expression of oncogenic Ras is known to inhibit myoblast differentiation and to decrease the expression of MyoD mRNA and protein. Our laboratory was the first to report that expression of oncogenic Ras also blocks the apoptotic process. While it is well known that MyoD and Myf5 function somewhat redundantly with respect to their role in the differentiation process, neither the role of Myf5 in the apoptotic process nor the regulation of Myf5 by oncogenic Ras has been investigated. Herein we report that, unlike MyoD, Myf5 is not sufficient to induce apoptosis. Further, like MyoD, Myf5 expression is decreased in both myoblasts and fibroblasts expressing oncogenic Ras. Additionally, we report that the mechanism of this inhibition is not a consequence of reducing Myf5 mRNA level

Spectral shift and Q-change of circular and square-shaped optical microcavity modes due to periodic sidewall surface roughness

Radiation loss and resonant frequency shift due to sidewall surface roughness of circular and square high-contrast microcavities are estimated and compared by using a boundary integral equations method. An effect of various harmonic components of the contour perturbation on the Whispering-Gallery (WG) modes in the circular microdisk and WG-like modes in the square microcavity is demonstrated. In both cases, contour deformations that are matched to the mode field pattern cause the most significant frequency detuning and Q-factor change. Favorably mode-matched deformations have been found, enabling one to manipulate the Q-factors of the microcavity modes.Comment: 5 pages with 6 figure