ECC Memory for Fault Tolerant RISC-V Processors

Numerous processor cores based on the popular RISC-V Instruction Set Architecture have been developed in the past few years and are freely available. The same applies for RISC-V ecosystems that allow to implement System-on-Chips with RISC-V processors on ASICs or FPGAs. However, so far only very little concepts and implementations for fault tolerant RISC-V processors are existing. This inhibits the use of RISC-V for safety-critical applications (as in the automotive domain) or within radiation environments (as in the aerospace domain). This work enhances the existing implementations Rocket and BOOM with a generic Error Correction Code (ECC) protected memory as a first step towards fault tolerance. The impact of the ECC additions on performance and resource utilization are discussed

Isospin Breaking in B -> K^* gamma Decays

A calculation of the leading isospin-breaking contributions to the B -> K^* gamma decay amplitudes based on the QCD factorization approach is presented. They arise at order Lambda/m_b in the heavy-quark expansion and are due to annihilation contributions from 4-quark operators, the chromo-magnetic dipole operator, and charm penguins. In the Standard Model the decay rate for B^0 -> K^{*0} gamma is predicted to be about 10-20 % larger than that for B^- -> K^{*-} gamma. Isospin-breaking effects are a sensitive probe of the penguin sector of the effective weak Hamiltonian. New Physics models in which the hierarchy of B -> K^* gamma decay rates is either flipped or greatly enhanced could be ruled out with more precise data.Comment: 11 pages, 2 figures. Extended version to appear in Physics Letters B. Includes an additional section with a discussion of New Physics effect

Flavour SU(3) Symmetry in Charmless B Decays

QCD sum rules are used to estimate the flavour SU(3)-symmetry violation in two-body B decays to pions and kaons. In the factorizable amplitudes the SU(3)-violation manifests itself in the ratio of the decay constants f_K/f_pi and in the differences between the B->K, B_s->K and B->pi form factors. These effects are calculated from the QCD two-point and light-cone sum rules, respectively, in terms of the strange quark mass and the ratio of the strange and nonstrange quark-condensate densities. Importantly, QCD sum rules predict that SU(3) breaking in the heavy-to-light form factors can be substantial and does not vanish in the heavy-quark mass limit. Furthermore, we investigate the strange-quark mass dependence of nonfactorizable effects in the B->K pi decay amplitudes. Taking into account these effects we estimate the accuracy of several SU(3)-symmetry relations between charmless B-decay amplitudes.Comment: Two references added, version to be published in Phys.Rev.D, 21 pages, 12 postscript figure

Exclusive Charmless BB Decays in QCD

The problem of hadronic input in charmless nonleptonic B decays is discussed. QCD sum rules and their light-cone versions (LCSR) provide an important part of this input, such as the decay constant $f_B$ and $B\to \pi$ form factor. Employing the LCSR technique, the $B\to \pi\pi$ hadronic matrix elements with emission, penguin and annihilation topologies are calculated, with no evidence for large nonfactorizable effects and/or strong phases.Comment: 6 pages, Invited talk at the First Workshop on Theory, Phenomenology and Experiments in Heavy Flavour Physics, Anacapri, Italy, May 29-31 200

Tight Glycemic Control After Pediatric Cardiac Surgery in High-Risk Patient Populations

Background—Our previous randomized, clinical trial showed that postoperative tight glycemic control (TGC) for children undergoing cardiac surgery did not reduce the rate of health care–associated infections compared with standard care (STD). Heterogeneity of treatment effect may exist within this population. Methods and Results—We performed a post hoc exploratory analysis of 980 children from birth to 36 months of age at the time of cardiac surgery who were randomized to postoperative TGC or STD in the intensive care unit. Significant interactions were observed between treatment group and both neonate (age ≤30 days; P=0.03) and intraoperative glucocorticoid exposure (P=0.03) on the risk of infection. The rate and incidence of infections in subjects ≤60 days old were significantly increased in the TGC compared with the STD group (rate: 13.5 versus 3.7 infections per 1000 cardiac intensive care unit days, P=0.01; incidence: 13% versus 4%, P=0.02), whereas infections among those \u3e60 days of age were significantly reduced in the TGC compared with the STD group (rate: 5.0 versus 14.1 infections per 1000 cardiac intensive care unit days, P=0.02; incidence: 2% versus 5%, P=0.03); the interaction of treatment group by age subgroup was highly significant (P=0.001). Multivariable logistic regression controlling for the main effects revealed that previous cardiac surgery, chromosomal anomaly, and delayed sternal closure were independently associated with increased risk of infection. Conclusions—This exploratory analysis demonstrated that TGC may lower the risk of infection in children \u3e60 days of age at the time of cardiac surgery compared with children receiving STD. Meta-analyses of past and ongoing clinical trials are necessary to confirm these findings before clinical practice is altered

Basal channels drive active surface hydrology and transverse ice shelf fracture

Ice shelves control sea-level rise through frictional resistance, which slows the seaward flow of grounded glacial ice. Evidence from around Antarctica indicates that ice shelves are thinning and weakening, primarily driven by warm ocean water entering into the shelf cavities. We have identified a mechanism for ice shelf destabilization where basal channels underneath the shelves cause ice thinning that drives fracture perpendicular to flow. These channels also result in ice surface deformation, which diverts supraglacial rivers into the transverse fractures. We report direct evidence that a major 2016 calving event at Nansen Ice Shelf in the Ross Sea was the result of fracture driven by such channelized thinning and demonstrate that similar basal channel–driven transverse fractures occur elsewhere in Greenland and Antarctica. In the event of increased basal and surface melt resulting from rising ocean and air temperatures, ice shelves will become increasingly vulnerable to these tandem effects of basal channel destabilization

The b quark low-scale running mass from Upsilon sum rules

The b quark low-scale running mass m_kin is determined from an analysis of the Upsilon sum rules in the next-to-next-to-leading order (NNLO). It is demonstrated that using this mass one can significantly improve the convergence of the perturbation series for the spectral density moments. We obtain m_kin(1 GeV) = 4.56 \pm 0.06 GeV. Using this result we derive the value of the MS-bar mass m: m(m) = 4.20 \pm 0.1 GeV. Contrary to the low-scale running mass, the pole mass of the b quark cannot be reliably determined from the sum rules. As a byproduct of our study we find the NNLO analytical expression for the cross section e+e- --> Q\bar Q of the quark antiquark pair production in the threshold region, as well as the energy levels and the wave functions at the origin for the ^1S_3 bound states of Q\bar Q.Comment: 22 pages, Late

Design and Rationale of Safe Pediatric Euglycemia After Cardiac Surgery (SPECS): A Randomized Controlled Trial of Tight Glycemic Control After Pediatric Cardiac Surgery

Objectives: To describe the design of a clinical trial testing the hypothesis that children randomized to tight glycemic control with intensive insulin therapy after cardiac surgery will have improved clinical outcomes compared to children randomized to conventional blood glucose management. Design: Two-center, randomized controlled trial. Setting: Cardiac ICUs at two large academic pediatric centers. Patients: Children from birth to those aged 36 months recovering in the cardiac ICU after surgery with cardiopulmonary bypass. Interventions: Subjects in the tight glycemic control (intervention) group receive an intravenous insulin infusion titrated to achieve normoglycemia (target blood glucose range of 80–110 mg/dL; 4.4–6.1 mmol/L). The intervention begins at admission to the cardiac ICU from the operating room and terminates when the patient is ready for discharge from the ICU. Continuous glucose monitoring is performed during insulin infusion to minimize the risks of hypoglycemia. The standard care group has no target blood glucose range. Measurements and Main Results: The primary outcome is the development of any nosocomial infection (bloodstream, urinary tract, and surgical site infection or nosocomial pneumonia). Secondary outcomes include mortality, measures of cardiorespiratory function and recovery, laboratory indices of nutritional balance, immunologic, endocrinologic, and neurologic function, cardiac ICU and hospital length of stay, and neurodevelopmental outcome at 1 and 3 yrs of age. A total of 980 subjects will be enrolled (490 in each treatment arm) for sufficient power to show a 50% reduction in the prevalence of the primary outcome. Conclusions: Pediatric cardiac surgery patients may recognize great benefit from tight glycemic control in the postoperative period, particularly with regard to reduction of nosocomial infections. The Safe Pediatric Euglycemia after Cardiac Surgery trial is designed to provide an unbiased answer to the question of whether this therapy is indeed beneficial and to define the associated risks of therapy

Charged-Higgs phenomenology in the Aligned two-Higgs-doublet model

The alignment in flavour space of the Yukawa matrices of a general two-Higgs-doublet model results in the absence of tree-level flavour-changing neutral currents. In addition to the usual fermion masses and mixings, the aligned Yukawa structure only contains three complex parameters, which are potential new sources of CP violation. For particular values of these three parameters all known specific implementations of the model based on discrete Z_2 symmetries are recovered. One of the most distinctive features of the two-Higgs-doublet model is the presence of a charged scalar. In this work, we discuss its main phenomenological consequences in flavour-changing processes at low energies and derive the corresponding constraints on the parameters of the aligned two-Higgs-doublet model.Comment: 46 pages, 19 figures. Version accepted for publication in JHEP. References added. Discussion slightly extended. Conclusions unchange