Comparisons Between Modeling and Measured Performance of the BNL Linac

Quite good agreement has been achieved between computer modeling and actual performance of the Brookhaven 200 MeV Linac. We will present comparisons between calculated and measured performance for the beam transport through the RFQ, the 6 meter transport from RFQ to the linac and meching and transport through the linac.Comment: 3 page

A Super-Conducting Linac Driver for the HFBR

This paper reports on the feasibility study of a proton Super-Conducting Linac (SCL) as a driver gor the High-Flux Breader Reactor (HFBR) at Brookhaven National Laboratory (BNL). The Linac operates in Continuos Wave (CW) mode to produce an average 10 MW of beam power. The Linac energy is 1.0 GeV. The average proton beam intensity is 10 mA.Comment: 3 page

The relevance of point defects in studying silica-based materials from bulk to nanosystems

The macroscopic properties of silica can be modified by the presence of local microscopic modifications at the scale of the basic molecular units (point defects). Such defects can be generated during the production of glass, devices, or by the environments where the latter have to operate, impacting on the devices’ performance. For these reasons, the identification of defects, their generation processes, and the knowledge of their electrical and optical features are relevant for microelectronics and optoelectronics. The aim of this manuscript is to report some examples of how defects can be generated, how they can impact device performance, and how a defect species or a physical phenomenon that is a disadvantage in some fields can be used as an advantage in others

A Motivating Exploration on Lunar Craters and Low-Energy Dynamics in the Earth -- Moon System

It is known that most of the craters on the surface of the Moon were created by the collision of minor bodies of the Solar System. Main Belt Asteroids, which can approach the terrestrial planets as a consequence of different types of resonance, are actually the main responsible for this phenomenon. Our aim is to investigate the impact distributions on the lunar surface that low-energy dynamics can provide. As a first approximation, we exploit the hyberbolic invariant manifolds associated with the central invariant manifold around the equilibrium point L_2 of the Earth - Moon system within the framework of the Circular Restricted Three - Body Problem. Taking transit trajectories at several energy levels, we look for orbits intersecting the surface of the Moon and we attempt to define a relationship between longitude and latitude of arrival and lunar craters density. Then, we add the gravitational effect of the Sun by considering the Bicircular Restricted Four - Body Problem. As further exploration, we assume an uniform density of impact on the lunar surface, looking for the regions in the Earth - Moon neighbourhood these colliding trajectories have to come from. It turns out that low-energy ejecta originated from high-energy impacts are also responsible of the phenomenon we are considering.Comment: The paper is being published in Celestial Mechanics and Dynamical Astronomy, vol. 107 (2010

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. In the present study, we describe a highly selective and potent inhibitor of Vps34, termed VPS34-IN1, that inhibits Vps34 with 25 nM ICin vitro, but does not significantly inhibit the activity of 340 protein kinases or 25 lipid kinases tested that include all isoforms of class I as well as class II PI3Ks. Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1 min, without affecting the ability of class I PI3K to regulate Akt. Moreover, we explored whether SGK3 (serum- and glucocorticoid-regulated kinase-3), the only protein kinase known to interact specifically with PtdIns(3)P via its N-terminal PX domain, might be controlled by Vps34. Mutations disrupting PtdIns(3)P binding ablated SGK3 kinase activity by suppressing phosphorylation of the T-loop [PDK1 (phosphoinositide-dependent kinase 1) site] and hydrophobic motif (mammalian target of rapamycin site) residues. VPS34-IN1 induced a rapid ~50-60% loss of SGK3 phosphorylation within 1 min. VPS34-IN1 did not inhibit activity of the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain. Furthermore, class I PI3K inhibitors (GDC-0941 and BKM120) that do not inhibit Vps34 suppressed SGK3 activity by ~40%. Combining VPS34-IN1 and GDC-0941 reduced SGK3 activity ~80-90%. These data suggest SGK3 phosphorylation and hence activity is controlled by two pools of PtdIns(3)P. The first is produced through phosphorylation of PtdIns by Vps34 at the endosome. The second is due to the conversion of class I PI3K product, PtdIns(3,4,5)P3 into PtdIns(3)P, via the sequential actions of the PtdIns 5-phosphatases [SHIP1/2 (Src homology 2-domain-containing inositol phosphatase 1/2)] and PtdIns 4-phosphatase [INPP4B (inositol polyphosphate 4-phosphatase type II)]. VPS34-IN1 will be a useful probe to delineate physiological roles of the Vps34. Monitoring SGK3 phosphorylation and activity could be employed as a biomarker of Vps34 activity, in an analogous manner by which Akt is used to probe cellular class I PI3K activity. Combining class I (GDC-0941) and class III (VPS34-IN1) PI3K inhibitors could be used as a strategy to better analyse the roles and regulation of the elusive class II PI3K

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Contains fulltext : 138516.pdf (publisher's version ) (Open Access)Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg2+ transport and impaired renal Mg2+ reabsorption. TRPM6, together with its homologue TRPM7, are unique proteins as they combine an ion channel domain with a C-terminally fused protein kinase domain. How TRPM6 channel and kinase activity are linked is unknown. Previous structural analysis revealed that TRPM7 possesses a non-catalytic dimerization motif preceding the kinase domain. This interacts with a dimerization pocket lying within the kinase domain. In the present study, we provide evidence that the dimerization motif in TRPM6 plays a critical role in regulating kinase activity as well as ion channel activity. We identify mutations within the TRPM6 dimerization motif (Leu1718 and Leu1721) or dimerization pocket (L1743A, Q1832K, A1836N, L1840A and L1919Q) that abolish dimerization and establish that these mutations inhibit protein kinase activity. We also demonstrate that kinase activity of a dimerization motif mutant can be restored by addition of a peptide encompassing the dimerization motif. Moreover, we observe that mutations that disrupt the dimerization motif and dimerization pocket interaction greatly diminish TRPM6 ion channel activity, in a manner that is independent of kinase activity. Finally, we analyse the impact on kinase activity of ten disease-causing missense mutations that lie outwith the protein kinase domain of TRPM6. This revealed that one mutation lying nearby the dimerization motif (S1754N), found previously to inhibit channel activity, abolished kinase activity. These results provide the first evidence that there is structural co-ordination between channel and kinase activity, which is mediated by the dimerization motif and pocket interaction. We discuss that modulation of this interaction could comprise a major regulatory mechanism by which TRPM6 function is controlled

Alessi 95 and the short period Cepheid SU Cassiopeiae

The parameters for the newly-discovered open cluster Alessi 95 are established on the basis of available photometric and spectroscopic data, in conjunction with new observations. Colour excesses for spectroscopically-observed B and A-type stars near SU Cas follow a reddening relation described by E(U-B)/E(B-V)=0.83+0.02*E(B-V), implying a value of R=Av/E(B-V)~2.8 for the associated dust. Alessi 95 has a mean reddening of E(B-V)_(B0)=0.35+-0.02 s.e., an intrinsic distance modulus of Vo-Mv=8.16+-0.04 s.e. (+-0.21 s.d.), d=429+-8 pc, and an estimated age of 10^8.2 yr from ZAMS fitting of available UBV, CCD BV, NOMAD, and 2MASS JHKs observations of cluster stars. SU Cas is a likely cluster member, with an inferred space reddening of E(B-V)=0.33+-0.02 and a luminosity of =-3.15+-0.07 s.e., consistent with overtone pulsation (P_FM=2.75 d), as also implied by the Cepheid's light curve parameters, rate of period increase, and Hipparcos parallaxes for cluster stars. There is excellent agreement of the distance estimates for SU Cas inferred from cluster ZAMS fitting, its pulsation parallax derived from the infrared surface brightness technique, and Hipparcos parallaxes, which all agree to within a few percent.Comment: Accepted for Publication (MNRAS

BNL-65813 ? ACHROMAT WITH LINEAR SPACE CHARGE FOR BUNCHED BEAMS*

Abstract The standard definition for an achromat is a transport line having zero values for the spatial dispersion (R16) and the anguhw dispersion (R26). For a bunched beam with linear space charge this definition of achromaticity does not hold. The linear space charge in the presence of a bend provides coupliig between (a) bunch spatial width and bunch length (RI 5) and (b) bunch angular spread and bunch length (R25). Therefore, achromat.icity should here defined as a line having zero values of the spatial dispersion (R16), the angular dispersion (R26), and matrix elements R15 & R25. These additional conditions (R15=R25=O) can be achieved, for example, with two small RF cavities at appropriate locations in the achromat, to cancel space charge effects. An example of the application of thh teehnique to the Spallation Neutron Source (SNS) high energy beam transport line will be presented