Direct Synthesis of α-Aryl-α-Trifluoromethyl Alcohols via Nickel Catalyzed Cross-Electrophile Coupling

A nickel-catalyzed reductive cross-electrophile coupling between the redox-active N-trifluoroeth-oxyphthalimide and iodoarenes is documented. The protocol reproduces a formal arylation of trifluoroacetaldehyde under mild conditions in high yields (up to 88 %) and with large functional group tolerance (30 examples). A combined computational and experimental investigation revealed a pivotal solvent assisted 1,2-Hydrogen Atom Transfer (HAT) process to generate a nucleophilic α-hydroxy-α-trifluoromethyl C-centered radical for theC sp2Csp3 bond forming process

Molecular hydrogen deficiency in HI-poor galaxies and its implications for star formation

We use a sample of 47 homogeneous and high sensitivity CO images taken from the Nobeyama and BIMA surveys to demonstrate that, contrary to common belief, a significant number (~40%) of HI-deficient nearby spiral galaxies are also depleted in molecular hydrogen. While HI-deficiency by itself is not a sufficient condition for molecular gas depletion, we find that H2 reduction is associated with the removal of HI inside the galaxy optical disk. Those HI-deficient galaxies with normal H2 content have lost HI mainly from outside their optical disks, where the H2 content is low in all galaxies. This finding is consistent with theoretical models in which the molecular fraction in a galaxy is determined primarily by its gas column density. Our result is supported by indirect evidence that molecular deficient galaxies form stars at a lower rate or have dimmer far infrared fluxes than gas rich galaxies, as expected if the star formation rate is determined by the molecular hydrogen content. Our result is consistent with a scenario in which, when the atomic gas column density is lowered inside the optical disk below the critical value required to form molecular hydrogen and stars, spirals become quiescent and passive evolving systems. We speculate that this process would act on the time-scale set by the gas depletion rate and might be a first step for the transition between the blue and red sequence observed in the color-magnitude diagram.Comment: 12 pages, 9 figures, accepted for publication in Ap

Gas-Bearing Early-Type Dwarf Galaxies in Virgo: Evidence for Recent Accretion

We investigate the dwarf (M_B> -16) galaxies in the Virgo cluster in the radio, optical, and ultraviolet regimes. Of the 365 galaxies in this sample, 80 have been detected in HI by the Arecibo Legacy Fast ALFA survey. These detections include 12 early-type dwarfs which have HI and stellar masses similar to the cluster dwarf irregulars and BCDs. In this sample of 12, half have star-formation properties similar to late type dwarfs, while the other half are quiescent like typical early-type dwarfs. We also discuss three possible mechanisms for their evolution: that they are infalling field galaxies that have been or are currently being evolved by the cluster, that they are stripped objects whose gas is recycled, and that the observed HI has been recently reaccreted. Evolution by the cluster adequately explains the star-forming half of the sample, but the quiescent class of early-type dwarfs is most consistent with having recently reaccreted their gas.Comment: 18 pages, 9 figure

Evaluation of eating habits and lifestyle in patients with obesity before and after bariatric surgery: a single Italian center experience

Background: The study evaluated and compared the eating habits and lifestyle of patients with moderate to severe obesity who have undergone Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG). Methods: Food frequency (FF), food habits (FH), physical activity and life style (PA) as well as smoking habits (SH) were analyzed in 50 RYGB (25 M; aged: 24–64) and 50 SG patients (25 M; aged: 22–63) by means of a validated questionnaire, before (T0) and 6 months (T1) post bariatric surgery. A score for each section (FF, FH, PA, SH) was calculated. Results: ANOVA analysis (age/sex adjusted): FF and FH scores improved at T1 (RYGB and SG: p < 0.001); PA score improved but not significantly; SH score did not change at T1 neither in RYGB nor in SG. Mixed models: FF and PA scores did not correlate with age, gender, weight, BMI, neither in RYGB nor in SG; FH score was negatively correlated both with weight (RYGB: p = 0.002) and BMI (SG: p = 0.003); SH score was positively correlated with age, in SG (p = 0.002); the correlation was stronger in females than in males (p = 0.004). Conclusions: Although dietary habits improved, patients did not change their physical activity level or their smoking habits. Patients should receive adequate lifestyle counseling to ensure the maximal benefit from bariatric surgery

A circular RNA map for human induced pluripotent stem cells of foetal origin

Background Adult skin fibroblasts represent the most common starting cell type used to generate human induced pluripotent stem cells (F-hiPSC) for clinical studies. Yet, a foetal source would offer unique advantages, primarily the absence of accumulated somatic mutations. Herein, we generated hiPSC from cord blood multipotent mesenchymal stromal cells (MSC-hiPSC) and compared them with F-hiPSC. Assessment of the full activation of the pluripotency gene regulatory network (PGRN) focused on circular RNA (circRNA), recently proposed to participate in the control of pluripotency. Methods Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-hiPSC were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to F-hiPSC. High-throughput array-based approaches and bioinformatics analyses were applied to address the PGRN. • View related content for this article Findings Cord blood MSC-hiPSC successfully acquired a complete pluripotent identity. Functional comparison with F-hiPSC showed no differences in terms of i) generation of mesenchymal-like derivatives, ii) their subsequent adipogenic, osteogenic and chondrogenic commitment, and iii) their hematopoietic support ability. At the transcriptional level, specific subsets of mRNA, miRNA and circRNA (n = 4,429) were evidenced, casting a further layer of complexity on the PGRN regulatory crosstalk. Interpretation A circRNA map of transcripts associated to naïve and primed pluripotency is provided for hiPSC of clinical-grade foetal origin, offering insights on still unreported regulatory circuits of the PGRN to consider for the optimization and development of efficient differentiation protocols for clinical translation

The complications of male hypogonadism: is it just a matter of low testosterone?

The history of diagnosing hypogonadism and hypotestosteronemia shows us the many steps that were necessary to achieve our current knowledge and the ability to improve these patients’ well-being. Moreover, so far, criteria for diagnosing hypotestosteronemia varies according to the underlying condition, and according to the consensus or guideline adopted. Furthermore, besides the many signs and symptoms, there are several complications associated with low testosterone levels such as osteoporosis, metabolic alterations, as well as cardiovascular disorders. However, data are often conflicting regarding the severity, timing or even the real clinical relevance of these complications, although these studies often lack essential information such as gonadotropin levels or the underlying cause of hypogonadism. The present review focus on the complications of male hypogonadism according to the cause of testosterone deficiency, highlighting the lack of information found in many studies investigating its effects. We thereby stress the necessity to always perform a complete evaluation of the type of hypogonadism (including at least gonadotropins and secondary causes) when investigating the effects of low testosterone levels

65 kpc of ionized gas trailing behind NGC 4848 during its first crossing of the Coma cluster

In a 5 hour Halpha exposure of the N-W region of the Coma cluster with the 2.1m telescope at SPM (Mx) we discovered a 65 kpc cometary emission of ionized gas trailing behind the SBab galaxy NGC 4848. The tail points in the opposite direction of the cluster center, in the same direction where stripped HI has been detected in previous observations. The galaxy shows bright HII regions in an inner ring-like pattern, where the star formation takes place at the prodigious rate of 8.9 Msun/yr. From the morphology of the galaxy and of the trailing material, we infer that the galaxy is suffering from ram pressure due to its high velocity motion through the cluster IGM. We estimate that 4 x 10^9 Msun of gas is swept out from the galaxy forming the tail. Given the ambient conditions in the Coma cluster (rho = 6.3 x 10^-27 g/cm^3; sigma_vel = 940 km/s) simulations predict that the ram pressure mechanism is able to remove such an amount of gas in less than 200 Myr. This, combined with the geometry of the interaction, indicating radial infall into the cluster, leads to the conclusion that NGC 4848 is caught in its first passage through the dense cluster environment.Comment: 7 pages, 2 figures, 3 tables, Accepted for publication in Astronomy and Astrophysics (18.07.12

Colorectal cancer after bariatric surgery (Cric-Abs 2020): Sicob (Italian society of obesity surgery) endorsed national survey

Background The published colorectal cancer (CRC) outcomes after bariatric surgery (BS) are conflicting, with some anecdotal studies reporting increased risks. The present nationwide survey CRIC-ABS 2020 (Colo-Rectal Cancer Incidence-After Bariatric Surgery-2020), endorsed by the Italian Society of Obesity Surgery (SICOB), aims to report its incidence in Italy after BS, comparing the two commonest laparoscopic procedures-Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (GBP). Methods Two online questionnaires-first having 11 questions on SG/GBP frequency with a follow-up of 5-10 years, and the second containing 15 questions on CRC incidence and management, were administered to 53 referral bariatric, high volume centers. A standardized incidence ratio (SIR-a ratio of the observed number of cases to the expected number) with 95% confidence intervals (CI) was calculated along with CRC incidence risk computation for baseline characteristics. Results Data for 20,571 patients from 34 (63%) centers between 2010 and 2015 were collected, of which 14,431 had SG (70%) and 6140 GBP (30%). 22 patients (0.10%, mean age = 53 +/- 12 years, 13 males), SG: 12 and GBP: 10, developed CRC after 4.3 +/- 2.3 years. Overall incidence was higher among males for both groups (SG: 0.15% vs 0.05%; GBP: 0.35% vs 0.09%) and the GBP cohort having slightly older patients. The right colon was most affected (n = 13) and SIR categorized/sex had fewer values &lt; 1, except for GBP males (SIR = 1.07). Conclusion Low CRC incidence after BS at 10 years (0.10%), and no difference between procedures was seen, suggesting that BS does not trigger the neoplasm development