Paleomagnetic Evidence for 25–15 Ma Crust Fragmentation of North Indochina (23–26°N): Consequence of Collision With Greater India NE Corner?

AbstractThe Cenozoic deformation of SE Asia is classically related to India‐Asia collision and Tibet Plateau rise, supposedly resulting in the southeastward drift of lithospheric blocks bounded by strike‐slip faults with displacements in the order of 1,000 km. Here we report on the paleomagnetism of 44 Triassic‐Cretaceous red bed sites from the northern Simao, Chuandian, and Lanping "blocks," along both sides of the Ailao Shan‐Red River shear zone (north Indochina). In the Simao domain, remagnetization predates folding and subsequent 48–70° clockwise rotation of three 2–5 km wide subblocks separated by two unrotated blocks. A primary magnetization component from the Lanping domain center suggests variably clockwise rotated (up to 95° ± 24°) sites, interrupted by a 2–6 km wide block that is rotated counterclockwise by 27° ± 6°. Thus, the Lanping and Simao "blocks" are far from being rigid, being made of a mosaic of independently deforming subblocks, whose kinematics and association with documented tectonics are speculative. It is unclear whether both folding and widespread remagnetization were synchronous or diachronous across north Indochina, but (considering previously published results) strike‐slip activity along major shear zones, remagnetization, rotations, and crustal shortening overlapped within the 32–15 Ma time window, thus were likely genetically related. As opposed to previous models, we suggest that in early to mid‐Cenozoic times, north Indochina was under the influence of oblique Neo‐Tethys subduction. Collision between the NE corner of Greater India and Indochina at ~30 Ma yielded ENE‐WSW shortening and strike‐slip reactivation of preexisting faults, in turn fragmenting the crust into small, independently rotating, blocks

Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis

Growing evidence is showing a role of neurogenic inflammation in allergic reactions, with sensory and autonomic nerve fibers releasing neuromediators, which may actively participate in the allergic inflammatory cascade. Although the cornea is the most densely innervated tissue of the human body, little is known on the role of neuromediators at the ocular surface. In this study, we aimed at evaluating the role of substance P (SP), calcitonine gene related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in allergic reactions of the ocular surface

Descompassos entre a lei e o cotidiano nos abrigos: percursos do ECA

O texto apresenta debates referentes a uma pesquisa bibliográfica que analisou produções escritas sobre o tema do abrigamento de crianças e jovens. Tal pesquisa visou cartografar as narrativas escritas sobre abrigos e convivência familiar a partir do ano 2000, quando, após dez anos da promulgação do Estatuto da Criança e do Adolescente (ECA), a consolidação de seus princípios na sociedade poderia ser esperada e sua implantação discutida. Dentre as categorias de análise levantadas, uma delas, “Ditos do ECA e cotidiano dos abrigos”, problematiza as mudanças produzidas pelo Estatuto na lógica de assistência à infância, interrogando-as através das práticas cotidianas dos abrigos. As análises feitas apontam divergências entre a lei e essas práticas, qualificando o abrigo como um espaço protetor dos direitos de crianças e jovens, mas ao mesmo tempo violador desses mesmos direitos, ao infringir a lei por outros percursos

ENTRE EFEITOS E PRODUÇÕES: ECA, ABRIGOS E SUBJETIVIDADES

O presente artigo pretende analisar questões levantadas pela pesquisa “Um outro lugar para a infância: dos complexos de internação aos abrigos para crianças e adolescentes”, procurando problematizar as práticas/discursos que atravessam os abrigos. As análises foram feitas a partir de entrevistas realizadas com profissionais ligados tanto aos antigos estabelecimentos de internação para crianças e adolescentes como aos atuais abrigos de proteção para infância e juventude. Dentre os analisadores que emergiram ao longo destas entrevistas, três deles foram selecionados para discutir as subjetividades produzidas e reproduzidas nos abrigos, a saber: 1) sombra dos internatos nos abrigos; 2) medicalização e psiquiatrização de crianças e adolescentes abrigados; 3) construção de autonomia

S-PRG-based toothpastes compared to NaF toothpaste and NaF varnish on dentin permeability in vitro

Objectives: To analyze the effect of 5 toothpastes containing different percentages of S-PRG fillers compared to NaF toothpaste and NaF varnish on the dentin hydraulic conductance (Lp). Methodology: Dentin disks (1.0±0.2 mm thickness) were cut from third molars, and their Lp values were evaluated using Flodec. The specimens were allocated into 7 groups (n=8). The minimum (smear layer) and the maximum (after acid etching) Lp values were recorded. Lp was also assessed after treatment with either a 0wt.%, 1wt.%, 5wt.%, 20wt.%, or 30wt.% S-PRG toothpaste, a NaF toothpaste, or a NaF varnish. Toothpastes were applied by brushing for 15 s, allowing it to settle for 1 min, and rinsing with deionized water. The NaF varnish was applied for 4 min and was removed with a probe. Specimens were exposed to citric acid (6%, pH 2.1, 1 min) and their final Lp was recorded. The pH of all products was recorded (n=3) and specimens from each group were analyzed by Laser Scanning Confocal Microscopy (LSCM). Data were subjected to 2-way repeated measures ANOVA and post-hoc Bonferroni (a=0.05). Results: The highest Lp reduction was noticed for the 5wt.% S-PRG toothpaste, NaF toothpaste, and NaF varnish. However, the toothpastes containing 5wt.%, 20wt.%, and 30wt.% of S-PRG were similar to all toothpastes but differed from the NaF varnish. After erosion, all groups retrieved their maximum Lp values, except for the NaF varnish. The LSCM evidenced deposits on the surface of specimens treated with 5%, 20%, and 30% S-PRG-based toothpastes and NaF toothpaste. Even more deposits were observed for the NaF varnish. After the erosive challenge, the deposits were diminished in all groups. Conclusion: Toothpastes containing 5wt.%, 20wt.%, and 30wt.% of S-PRG fillers behaved similarly to a conventional NaF toothpaste, even after an erosive challenge. The NaF varnish promoted better reduction of the Lp, but its effect was also diminished after erosion

Photochemical R2PI study of chirality and intermolecular forces in supersonic beam

One and two-color, mass selected R2PI spectra of theS1←S0transitions in the bare(+)-(R)- 1-phenyl-1-ethanol(ER) and its complexes with different solvent molecules (solv) (-)-(R)-2-butanol(BR) or(+)-(S)-2-butanol(BS), (—)-(R)-2-pentanol (TR) or(+)-(S)-2-pentanol(TS) and(-)-(R)-2-butylamine(AR) or(+)-(S)-2-butylamine(AS), have been recorded after a supersonic molecular beam expansion. The one-color R2PI excitation spectra of the diastereomeric complexes are characterized by significant shifts of their band origin relative to that of bareER. The extent and the direction of these spectral shifts are found to depend upon the structure and the configuration ofsolvand are attributed to different short-range interactions in the ground and excited states of the complexes. In analogy with other diastereomeric complexes, the phenomenological binding energy of the homochiral cluster is found to be greater than that of the heterochiral one. Preliminary measurements of excitation spectrum of(+)-(R)-1-Indanol(IR) is also reported

Strain-Induced Plasmon Confinement in Polycrystalline Graphene

Terahertz spectroscopy is a perfect tool to investigate the electronic intraband conductivity of graphene, but a phenom-enological model (Drude-Smith) is often needed to describe disorder. By studying the THz response of isotropically strained polycrystalline graphene and using a fully atomistic computational approach to fit the results, we demonstrate here the connection between the Drude-Smith parameters and the microscopic behavior. Importantly, we clearly show that the strain-induced changes in the conductivity originate mainly from the increased separation between the single-crystal grains, leading to enchanced localization of the plasmon excitations. Only at the lowest strain values explored, a behavior consistent with the deformation of the individual grains can instead be observed

Exploring Gender Diversity in Transgender and Non-Binary Adults Accessing a Specialized Service in Italy

In Italy, studies investigating gender identity and expression in gender non-conforming adults are lacking, as well as data regarding the non-binary population. The present study aimed at dimensionally exploring how transgender and non-binary Italian adults identify and express their gender. The Gender Diversity Questionnaire (GDQ) was administered to a sample of 112 adult subjects aged 18-60 years accessing a gender-specialized service in Rome. The majority of the participants were aged 18-24 years (53.6%), whereas fewer subjects were aged 25-35 years (32%) and 35 years and older (14.3%). Most participants (83.9%) identified themselves as trans binary, while the remaining (16.1%) identified as non-binary. Trans binary participants reported a stable gender identity, whereas non-binary participants reported a more fluid gender identity over time and across contexts. Younger subjects recognized the use of chosen names, pronouns, and clothes as important for their gender expression, whereas older subjects attributed more importance to physical appearance and emotions. Differences regarding gender-affirmative interventions emerged between non-binary and transbinary participants. Findings evidence that gender non-conforming adults accessing gender-specialized services have unique needs and features, thus it is essential to shed light on this population by providing greater visibility and recognition

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes.

Swiss mice were given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 25 mg/kg/day, for 5 consecutive days and killed at different days after MPTP discontinuance. Decreases in striatal tyrosine hydroxylase activity and levels of dopamine and its metabolites were observed 1 day after MPTP discontinuance. Ascorbic acid and glutamate levels had increased, dehydroascorbic acid and GSH decreased, whereas catabolites of high-energy phosphates (inosine, hypoxanthine, xanthine, and uric acid) were unchanged. In addition, gliosis was observed in both striatum and substantia nigra compacta (SNc). Sections of SNc showed some terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end labeling (TUNEL)-positive cells. Neurochemical parameters of dopaminergic activity showed a trend toward recovery 3 days after MPTP discontinuance. At this time point, TUNEL-positive cells were detected in SNc; some of them showed nuclei with neuronal morphology. A late (days 6-11) increase in striatal dopamine oxidative metabolism, ascorbic acid oxidative status, and catabolites of high-energy phosphates were observed concomitant with nigral neuron and nigrostriatal glial cell apoptotic death, as revealed by TUNEL, acridine orange, and Hoechst staining, and transmission electron microscopy. These data suggest that MPTP-induced activation/apoptotic death of glial cells plays a key role in the sequential linkage of neurochemical and cellular events leading to dopaminergic nigral neuron apoptotic death