A Systematisation of Methods for Heat Integration of Solar ThermalEnergy in Production Processes: A Review

The widespread use of fossil fuels and their limitation leads to find other sources of energy. Solar thermal energy is a possible solution. There are many projects that use renewable energy. Solar thermal energy can be easily used for heating. However, there are problems in the efficiency of solar collectors, the loss of heat, the consistency of heat supply, temperature and weather conditions, the biggest problem being the heat storage. In this paper is provided an overview of the methodologies for thermal integration of solar heating systems implemented in various projects and research. Solar heating systems have different designs and can generate heat in different temperature ranges. The main emphasis in this comprehensive overview is the systematisation of the various methodologies used in the integration of solar heat in production. In principle, solar heating systems are directly connected to the production systems. Furthermore, a few methodologies like Pinch technology, mathematical modelling and cogeneration are included

Paracelsus a pioneer of emergency medicine and surgery, the father of toxicology and pharmacology, the precursor of homeopathy and chemotherapy

In the entire constellation of doctors, pharmacists, physicists, alchemists, anatomists, pioneers of medicine, there are few who have left as much controversy behind as Paracelsus did. Paracelsus' real name was Theophrastus Philippus Aureolus Bombastus von Hohenheim and he was essentially an alchemist, physicist, astrologer and practiced the occult. His medical practice introduced numerous revolutionary treatments for that time, although many contemporaries considered his works to be a collection of superstitious and repulsive folk remedies. He wrote: "If you prevent the infection, nature will heal the wound on its own." This treatment brought him fame in the circles of Western medicine. He was also the first to introduce the use of various chemicals and minerals in treatment o illnes, the first to give the name zinc and introduced tin powder as an anthelmintic. In long ago 1530 Paracelsus wrote a clinical description of syphilis, in which he claimed that the disease could be successfully treated with orally, carefully measured doses of mercury compounds. During his stay in the mines holles, he wrote that the "miner's disease" (silicosis) was caused by inhaling metal fumes and that it was not a punishment for the sin used by mountain spirits. The first stated that, if given in small doses, "what makes a person sick also cures him" - expectation of the modern practice of homeopathy. It was written that Paracelsus cured many plague-stricken people in the city of Stertzing in the summer of 1534 by giving an oral tablet made of bread and secretion from the pustule. Paracelsus is often referred to as the father of toxicology. In that sense, his sentence is especially significant: "All things are poisonous and nothing is without poison; it's just the dose that makes a thing not poison." This remains the basic principle of toxicology to these days. Although he is often called a quack doctor, he is rightly among the 100 most influential scientists in all of human history

Influence of the Sodium Salt of 3α,7α-Dihydroxy-12-Oxo-5β-Cholanate on Antimicrobial Activity of Ampicillin In Vitro

Background: Multiple resistances to antibiotics are an emergent problem worldwide. Scientists intensively search for new substances with the antimicrobial potential or the mode to restore the activity of old-generation antibiotics. Ampicillin is the antibiotic with the expanded range of antimicrobial activity, but its use has decreased due to the poor absorption and highly developed resistance. In vivo studies showed that ampicillin has better absorption and bioavailability if combined with bile acid salts. The aim of this study was to examine antimicrobial effects of ampicillin alone and its combination with semisynthetic monoketocholic acid salt (MKH) in vitro.Materials, Methods & Results: In this study, commercial preparation of ampicillin and sodium salt of 3α,7α-dihydroxy-12oxo-5β-cholanate were used. Their effects were evaluated on Escherichia coli (E. coli), Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium), obtained from urine specimens of dogs with clinically manifested cystitis. The first two investigated strains were ampicillin-sensitive, while E. faecium was resistant to ampicillin. Modified macrodilution method according to Clinical and Laboratory Standards Institute Guidelines (M7-A8) was performed. Bacterial suspension equivalent to 0.5 McFarland was prepared in saline, compared to the standard (Biomerieux) ad oculi. The density was checked spectrophotometrically at a wavelength of 625 nm and adjusted if necessary to the desired absorbance from 0.08 to 0.1. The resultant suspension was diluted 1:100 and inoculated in test tubes. Number of bacteria was counted on Petri plates using dilutions from 10-3 to 10-7 in order to obtain valid and countable plates. One hundred microliters of appropriate dilutions were aseptically plated in triplicate onto nutrient agar. Plates were incubated on 37°C for 72 h, under aerobic conditions. The number of colony forming units (CFU) was determined by direct counting. As a valid for enumeration, we took plates with 30 to 300 CFU. Percentage of killed bacteria for ampicillin was from 69.33-95.19% for E. coli, 87.1296.92% for E. faecalis and 7.20-33.30% for E. faecium. Ampicillin applied in the combination with MKH killed 99.99% to 100% of E. coli, 94.59% to 99.91% of E. faecalis and 31.73% to 64.76% of E. faecium. Mean percentage of killed bacteria for ampicillin was 81.93% for E. coli, 91.64% for E. faecalis, and 18.13% for E. faecium, while in combination with MKH percentage was 99.96% for E. coli, 98.23% for E. faecalis and 47.54% for E. faecium.Discussion: Results are presented as pharmacological minimal inhibitory concentration (MIC) values. Ampicillin was applied at the concentration higher than the therapeutic one, which could explain high MIC values for E. coli and E. faecalis. The combination of ampicillin with MKH showed the best improvement of antimicrobial effect on E. faecium (Δ = 29.41%), isolate that was resistant to ampicillin when applied alone. In all the investigated isolates, the combinations with MKH were more effective than ampicillin administered alone. It seems that MKH demonstrates a synergistic antimicrobial activity with ampicillin in vitro, which considerably decreases MIC values for all investigated isolates. These results implicate that MKH could restore the previous activity of ampicillin against some bacteria, which could be a significant benefit for clinical practice

Economic analysis of field crop production on a family farm

An economic analysis of field crop (wheat, corn, triticale and sunflower) production on a family farm, representing a case-study average farm, during one production year involved calculation of production costs, gross margin, economic efficiency and rate of profitability. Calculations showed that the highest amount of gross margin was achieved with corn, followed by sunflower, triticale and wheat. The calculated values of the coefficient of efficiency were in the respective order: 3.59 for corn, 2.16 for sunflower, 1.89 for triticale and 1.79 for wheat. The share of variable costs was also indicated, with special emphasis on high costs of mineral fertilizers and machinery.Publishe

Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model

Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (p < 0.05). The same was true for low-density lipoprotein cholesterol and the LDL/HDL ratio (p < 0.05). Adiponectin was remarkably higher in animals treated with simvastatin compared to all other groups (p < 0.05). Leptin was significantly lower in groups treated with carob and simvastatin compared to the hypercholesterolemic group treated with saline (p < 0.05). Carob/simvastatin co-administration reduced hepatocyte damage and improved liver morphology. A study confirmed the anti-dyslipidemic, anti-obesity, and hepatoprotective potential of carob pulp alone or in combination with simvastatin in the treatment of high-fat diet-fed rats

The role of a pharmacist in pharmacovigilance system

Introduction: Although they represent an important mediator between patients and National Pharmacovigilance Centre, pharmacists still don't participate enough in system of reporting adverse drug reactions (ADR). By reporting ADR both quality of therapy and quality of patient's life are improving, and pharmaceutical industry is also encouraged to invent and produce new formulations which will be better beared and whose use will significantly improve risk-benefi t ratio. Aim: The aim of this work is that by collecting information about ADRs, based on direct contact of a pharmacist and patients, explain and improve the role of a pharmacist in pharmacovigilance system. Subjects and Methods: Information about adverse reactions were being collected in three private pharmacies in Inđija and in one private pharmacy in Sombor. In period from 20.12.2017.-10.01.2018. pharmacists collected data about adverse reactions of medicines. In period from 11.01.-01.02.2018. patients were additionally informed about unexpected and adverse drug reactions. The standard form for reporting an adverse reaction, which was taken from the site of Medicines and Medical Devices Agency of Serbia (ALIMS), was fi lled for each reported case and sent to National Pharmacovigilance Center (NPC). Suspect drugs were classified in categories according to Anatomical-Therapeutic-Chemical classification (ATC). Results: In first period, there were 19 reported reactions. After additional information given to patients, there were 33 reported adverse reactions. The most numerous adverse drug reactions were reported for the group of cardiovascular drugs (32.7%), the group of anti-infective drugs with systemic effects (15.4%) and for group of drugs which affect nervous system (13.5%). After analyzing reported reactions, according to NPC all of reactions were expected (52), but 3 of them fulfilled criteria of seriousness. Conclusions: Thanks to additional information and direct communication between a pharmacist and patients, reporting unexpected and adverse drug reactions is significantly improving

The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats

Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in male Wistar rats. The in vivo model was used to explore whether silymarin could prevent damage of liver and heart tissue induced by doxorubicin administered every other day at dose of 1.66 mg/kg intraperitoneally for twelve days. In the study the change of body weight, ECG changes, biochemical parameters of oxidative stress, serum activity of alanine and aspartate transaminase, lactate dehydrogenase, creatine kinase and histological preparations of heart and liver samples of treated animals were examined. According to physiological, pharmacological, microscopic and biochemical results, we confirmed that at the examined dose, silymarin exhibits a protective influence on the heart and liver tissue against toxicity induced by doxorubicin