N′-(Adamantan-2-yl­idene)thio­phene-2-carbohydrazide

In the title mol­ecule, C15H18N2OS, a small twist is noted, with the dihedral angle between the central carbohydrazone residue (r.m.s. deviation = 0.029 Å) and the thio­phene ring being 12.47 (10)°. The syn arrangement of the amide H and carbonyl O atoms allows for the formation of centrosymmetric dimers via N—H⋯O hydrogen bonds. These are linked in the three-dimensional structure by C—H⋯π inter­actions. The thio­phene ring is disordered over two co-planar orientations, the major component having a site-occupancy factor of 0.833 (2)

Sedimentological review of upper triassic (Mulussa F formation) in Euphrates-Graben Syria

© Medwell Journals, 2016.Mulussa F formation is one of the important geological formations constituting the Mulussa group in Syria. The objective of this research is to review of sediments Mulussa F formation. Its deposits contain almost 50% of hydrocarbon potential through Euphrates Graben. Boreholes data permitted confining the formation between two Lithostratigraphic markers and enabled its division into three Lithostratigraphic members MUF3, MUF2, MUF1 (from bottom to top). Each member consists of a set of units, subunits and lithologic intervals. Petrology studying provides a precise petrological description of various formation members and their Digenetic. Results show that the members of the structure are composed of continental detrital sediments made up of clay stones (Kaolinite/Illite) and Shale/Dolomitic clay stone, covered by intervals of quartz sandstones, clay sandstones and silt sandstones. The carbonate sediments are absent from the formation unless it's base which consists of Dolomitic clay stone and its top which are close to carbonate composition. This sediment of those members spread out as repeated or harmonic alternations whose faces gradients reflect transgression and regression sequences. Due to the historical value of Mulussa F formation, it is vital to investigate its sediments status. The study of these sediments leads to represent narrow barriers near river mouth with meandering channels and limited coastal deposits

Ultrasound confirmation of guidewire position may eliminate accidental arterial dilatation during central venous cannulation

<p>Abstract</p> <p>Background</p> <p>Ultrasound guidance during central line insertion has significantly reduced complications associated with this procedure and has led to it being incorporated as standard of care in many institutions. However, inadvertent arterial penetration and dilation remains a problem despite ultrasound guidance and can result in significant morbidity and even mortality. Dynamic ultrasound confirmation of guidewire position within the vein prior to dilation may help to prevent and even eliminate this feared complication.</p> <p>Methods</p> <p>A prospectively collected database of central line insertions for one author utilizing this novel technique was retrospectively reviewed for all incidents of arterial dilation over a period from September 2008 to January 2010.</p> <p>Results</p> <p>During the study period 53 central lines were inserted with no incidents of arterial dilation.</p> <p>Conclusions</p> <p>Ultrasound confirmation of guidewire position has the potential to reduce or eliminate the morbidity and mortality of arterial dilation during central line placement.</p

CALL in Post-Method Era

oai:ojs.indonesian-efl-journal.org:article/33This paper touches on the influx of technology in language learning and teaching with a focus on the post-method era. Scrutinizing this phenomenon within the framework of Computer-Assisted Language Learning (CALL) shows how technology has stimulated a transformation of language pedagogy from the traditional teacher-centered and text-bound classrooms to student-centered and interactive paradigms. While the former paradigm is based on methodology, the latter is guided by principled eclecticism in which teachers make use of a set of macro-strategies so as to make decisions while teaching, instead of reliance on methods that dictate ‘how to teach’. The teaching principles capitalize on teachers’ sensitivity to local contexts rather than general methods. Though CALL has been mooted as panacea for ELT flaws in the method and post-method eras, it is not a one-size-fits-all model. Due to changeable and diversified technological innovations, it is impractical to adopt an electronic device or application for all contexts. Accordingly, the post-method pedagogy puts the onus on language teachers to make informed choices that best fit the particularity of their teaching situations.

3-(Adamantan-1-yl)-4-ethyl-1-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C26H37N5OS, the piperazine ring adopts a chair conformation. The triazole ring forms dihedral angles of 67.85 (9) and 59.41 (9)� with the piperazine and benzene rings, respectively, resulting in an approximate Vshaped conformation for the molecule. An intramolecular C— H...O hydrogen bond generates an S(6) ring motif. The crystal structure features C—H...n interactions, producing a two-dimensional supramolecular architecture

EXTRA: Towards the exploitation of eXascale technology for reconfigurable architectures

© 2016 IEEE. To handle the stringent performance requirements of future exascale-class applications, High Performance Computing (HPC) systems need ultra-efficient heterogeneous compute nodes. To reduce power and increase performance, such compute nodes will require hardware accelerators with a high degree of specialization. Ideally, dynamic reconfiguration will be an intrinsic feature, so that specific HPC application features can be optimally accelerated, even if they regularly change over time. In the EXTRA project, we create a new and flexible exploration platform for developing reconfigurable architectures, design tools and HPC applications with run-time reconfiguration built-in as a core fundamental feature instead of an add-on. EXTRA covers the entire stack from architecture up to the application, focusing on the fundamental building blocks for run-time reconfigurable exascale HPC systems: new chip architectures with very low reconfiguration overhead, new tools that truly take reconfiguration as a central design concept, and applications that are tuned to maximally benefit from the proposed run-time reconfiguration techniques. Ultimately, this open platform will improve Europe's competitive advantage and leadership in the field

Echinacoside ameliorates hepatic fibrosis and tumor invasion in rats with thioacetamide-induced hepatocellular carcinoma

Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing need to identify new drugs that can combat resistance. One potential option is echinacoside, a natural caffeic acid glycoside with antioxidant, anti-inflammatory, antidepressant, and antidiabetic properties. Therefore, we aimed to investigate the ability of echinacoside to exhibit antitumor activity against HCC in rats through ameliorating hepatic fibrosis and tumor invasion. Rats were given thioacetamide to induce HCC, and some were given 30 mg/kg of echinacoside twice a week for 16 weeks. The liver impairment was assessed by measuring serum α-fetoprotein (AFP) and examining liver sections stained with Masson trichrome or anti-transforming growth factor (TGF)-β1 antibodies. The hepatic expression of mRNA and protein levels of TGF-β1, β-catenin, SMAD4, matrix metalloproteinase-9 (MMP9), phosphoinositide 3-kinases (PI3K), mammalian target of rapamycin (mTOR), connective tissue growth factor 2 (CCN2), E-Cadherin, platelets derived growth factor (PDGF)-B and fascin were also analyzed. Echinacoside improved the survival rate of rats by decreasing serum AFP and the number of hepatic nodules. Examination of micro-images indicated that echinacoside can reduce fibrosis. It also significantly decreased the expression of TGF-β1, β-catenin, SMAD4, MMP9, PI3K, mTOR, CCN2, PDGF-B, and fascin while enhancing the expression of E-Cadherin. In conclusion, echinacoside exhibits a protective effect against HCC by increasing survival rates and decreasing tumor growth. It also acts as an inhibitor of the hepatic tissue fibrosis pathway by reducing the expression of TGF-β1, β-catenin, SMAD4, PI3K, CCN2, PDGF-B and mTOR. Additionally, it prevents tumor invasion by suppressing MMP9 and fascin, and increasing the expression of E-Cadherin

Seasonal time-series modeling and forecasting of monthly mean temperature for decision making in the Kurdistan Region of Iraq

A generalized structural time-series modeling framework was used to analyze the monthly records of mean temperature, one of the most important environmental parameters, using classical stochastic processes. In this article we are using the SARIMA Box–Jenkins model and obtain a medium-term (10 years) forecast of the mean temperature in Erbil. A prediction of the monthly mean temperature during the past 287 months ((Formula presented.)24 years) using the SARIMA(0,1,2)(0,1,1)12 model predicts that the average temperature in the governorate of Erbil, Iraq, will be stable for the next 10 years. The evaluation of prediction accuracy shows that our model performs equally well when applying it to different periods of time for which data is available. The method used here could easily be applied by the decision makers responsible for providing water and electricity in the Kurdistan Region