4 research outputs found

    Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated <i>Sphaerimonospora mesophila</i>

    No full text
    Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus <i>Sphaerimonospora</i>. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. <i>In silico</i> analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20–40 μM without showing cytotoxicity
    corecore