Active Learning Approach in Simulated Health Guidance Utilizing ICT : Class Development and Improvement to Cultivate Practical Learning Instruction Abilities

　養護教諭の職務の重要な柱である保健指導の実践的指導力を育成するために，養成段階においても能動的学修を推進する必要がある。そこで教職科目「教育方法論」において，ICT を活用した能動的学修として模擬保健指導に取り組んだ。授業では，子どもの実態や健康課題に基づいて指導案を作成し保健指導の設計・実施・評価を一連の流れとしたグループ活動を展開した。平成25 年度から平成27 年度の3 年間の授業開発・改善の結果，「非常に到達目標を達成できた」とする学生は，平成25 年度の18.2%から平成27 年度は26.7%に増加した。「授業目標や内容が非常に理解できた」のは31.8%から60%，「教材が授業内容の理解や自宅学習に非常に役立った」のは40.9%から60%，2時間以上予習や課題にかける学生も18.2%から40%に増加した．保健指導の実践的指導力を育成し効果的な授業を可能とするためには，模擬保健指導をICT を活用した能動的学修にすることは有効といえる

Core-shell enhanced single particle model for lithium iron phosphate batteries: model formulation and analysis of numerical solutions

In this paper, a core-shell enhanced single particle model for iron-phosphate battery cells is formulated, implemented, and verified. Starting from the description of the positive and negative electrodes charge and mass transport dynamics, the positive electrode intercalation and deintercalation phenomena and associated phase transitions are described with the core-shell modeling paradigm. Assuming two phases are formed in the positive electrode, one rich and one poor in lithium, a core-shrinking problem is formulated and the phase transition is modeled through a shell phase that covers the core one. A careful discretization of the coupled partial differential equations is proposed and used to convert the model into a system of ordinary differential equations. To ensure robust and accurate numerical solutions of the governing equations, a sensitivity analysis of numerical solutions is performed and the best setting, in terms of solver tolerances, solid phase concentration discretization points, and input current sampling time, is determined in a newly developed probabilistic framework. Finally, unknown model parameters are identified at different C-rate scenarios and the model is verified against experimental data

Aggression, Social Stress, and the Immune System in Humans and Animal Models

Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression to antisocial and violence-related behaviors. Increasing evidence suggests that the immune system is involved in responses to social stress in adulthood. For example, human studies show that individuals with high aggression traits display heightened inflammatory cytokine levels and dysregulated immune responses such as slower wound healing. Similar findings have been observed in patients with depression, and comorbidity of depression and aggression was correlated with stronger immune dysregulation. Therefore, dysregulation of the immune system may be one of the mediators of social stress that produces aggression and/or depression. Similar to humans, aggressive animals also show increased levels of several proinflammatory cytokines, however, unlike humans these animals are more protected from infectious organisms and have faster wound healing than animals with low aggression. On the other hand, subordinate animals that receive repeated social defeat stress have been shown to develop escalated and dysregulated immune responses such as glucocorticoid insensitivity in monocytes. In this review we synthesize the current evidence in humans, non-human primates, and rodents to show a role for the immune system in responses to social stress leading to psychiatric problems such as aggression or depression. We argue that while depression and aggression represent two fundamentally different behavioral and physiological responses to social stress, it is possible that some overlapped, as well as distinct, pattern of immune signaling may underlie both of them. We also argue the necessity of studying animal models of maladaptive aggression induced by social stress (i.e., social isolation) for understanding neuro-immune mechanism of aggression, which may be relevant to human aggression

Core-shell enhanced single particle model for LiFePO4_4 batteries

In this paper, a novel electrochemical model for LiFePO$_4$ battery cells that accounts for the positive particle lithium intercalation and deintercalation dynamics is proposed. Starting from the enhanced single particle model, mass transport and balance equations along with suitable boundary conditions are introduced to model the phase transformation phenomena during lithiation and delithiation in the positive electrode material. The lithium-poor and lithium-rich phases are modeled using the core-shell principle, where a core composition is encapsulated with a shell composition. The coupled partial differential equations describing the phase transformation are discretized using the finite difference method, from which a system of ordinary differential equations written in state-space representation is obtained. Finally, model parameter identification is performed using experimental data from a 49Ah LFP pouch cell

高齢者看護学実習における学生の高齢患者の理解の実態

The purpose of this study was to clarify how the students understand the older patients based on Orem’s nursing theory in Geriatric Nursing Training. The participants were１７nursing students in third grade. The interview was carried out using semi-structured interview with students for how they felt older patients. As a result, two categories were extracted ; ［ they need limited care for deficient parts］and［they have toughness cultivated through their long life］. The students understood the older patients as having self-caring abilities and thought that limited care should be provided only for deficient parts of patients. Also, they understood older patients as having strength cultivated through their long life. It is necessary for teachers to assess the Self-care agency more severely for students to get hold of mature elements characteristic of older patients

Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance

Small extracellular vesicles (sEVs) are important mediators of cell–cell communication with respect to diverse physiological processes. To further understand their physiological roles, understanding blood sEV homoeostasis in a quantitative manner is desired. In this study, we propose novel kinetic approaches to estimate the secretion and clearance of mouse plasma–derived sEVs (MP-sEVs) based on the hypothesis that blood sEV concentrations are determined by a balance between the secretion and clearance of sEVs. Using our specific and sensitive sEV labelling technology, we succeeded in analysing MP-sEV clearance from the blood after intravenous administration into mice. This revealed the rapid disappearance of MP-sEVs with a half-life of approximately 7 min. Moreover, the plasma sEV secretion rate, which is presently impossible to directly evaluate, was calculated as 18 μg/min in mice based on pharmacokinetic (PK) analysis. Next, macrophage-depleted mice were prepared as a model of disrupted sEV homoeostasis with retarded sEV clearance. MP-sEV concentrations were increased in macrophage-depleted mice, which probably reflected a shift in the balance of secretion and clearance. Moreover, the increased MP-sEV concentration in macrophage-depleted mice was successfully simulated using calculated clearance rate constant, secretion rate constant and volume of distribution, suggesting the validity of our PK approaches. These results demonstrate that blood sEV concentration homoeostasis can be explained by the dynamics of rapid secretion/clearance

再発転移後の肺がん患者が持つ見通し

This study aimed at clarifying prospects that lung cancer patients undergoing treatment after recurrence and metastasis have. The study method is based on the qualitative descriptive study design. A semi-structured interview was performed for １３ lung cancer patients undergoing treatment after recurrence and metastasis. As a result, the following five categories were extracted［; Since it is recurrence and metastasis, the death is coming to me］［, I am undergoing treatment so I’m alright now but I’ll die someday］［, Let a matter take its own course］［, My life will be going as before］and［I will be living as long as I receive treatment］. Characteristics of the above are that all of the patients are ready to accept death and they had more than two prospects. They were characteristic of patients after recurrence and metastasis that symptoms that remind them of repeated treatment and death appear and there is uncertainty for their future. The above results have suggested the need to capture the state of each prospect while confirming the prospects of lung cancer patients under treatment after recurrence and metastasis