Comparison of the Effectiveness of Mellisan Gel and Acyclovir 5% Cream in the Improvement of Recurrent Herpes Labialis

BACKGROUND AND OBJECTIVE: Recurrent herpes labialis is a common infection of the mouth area, caused by herpes simplex virus. This infection appears in the mucus or lip skin and is commonly known as oral herpes. The purpose of this study was to compare the effectiveness of Mellisan gel and acyclovir 5% cream in the improvement of recurrent herpes labialis. METHODS: This double-blind clinical trial was conducted on 60 patients (14 men and 46 women), with the average age of 23.8 years (minimum of 20 and maximum of 32 years) and a prior history of recurrent herpes labialis three times a year. The previously-coded medicines were randomly distributed among patients. The subjects were asked to apply the cream or gel locally on the infected region three times a day, according to the manufacturer's instructions. All patients were examined within one, two, four and seven days after using the cream or gel to determine the changes in pain intensity, size of the ulcer, inflammation and recovery time. IRCT: 13870819144281.  FINDINGS: Mellisan gel and acyclovir cream were not significantly different in reducing the size of the ulcer, inflammation or the associated side-effects. Mellisan gel was accompanied by a significant reduction in pain intensity in patients on the second and fourth days of the examination (p=0.0001 and p=0.02, respectively). Moreover, on the second day, there was a significant difference in recovery (p=0.001). CONCLUSION: The results of this study suggested that Mellisan gel is more effective than acyclovir cream in terms of pain reduction and recovery, whereas no significant difference was observed regarding the size of the ulcer or inflammation. Also, the administration of Mellisan gel and acyclovir cream was associated with no side-effects

An investigation on the stimulated salivary flow rate in menopause and post menopause women

Statement of Problem: Menopause can exert extensive somatic and psychological effects on women at this stage including: oral complaints such as dry mouth, glossodynia, viscous saliva, although these findings should be studied further."nPurpose: The aim of this study was to investigate the stimulated salivary flow rate of 158 menopause and post menopause women."nMaterial and Methods: In this cross- sectional and analytic- descriptive study, 158 women, at post menopause stage, were selected as case group. The controls consisted of 83 same aged men. None of the subjects had any systemic disease and did not use any drugs. Age range, in both groups, was 50-69 years old. Psychical condition of two groups, were compared by HADSCALE test. Oral symptoms were also compared and evaluated. In order to analyze the results, "t" and "Mann- Whitney" tests were used. Results: No significant difference was found between two groups regarding the quantity of stimulated saliva and psychological condition, but the incidence of oral symptoms in case group was significantly higher than the control group (P=0.002)."nConclusion: Based on this study, although oral symptoms have a significant relation with menopause, can not be attributed to the quantity of saliva or psychical condition. In order to find the underlying reasons, more investigations should be performed on quality changes of saliva or other factors

ٍEvaluating Baremoom Mouthwash Efficacy in Treatment of Chemotherapy-Induced Mucositis

Introduction: Chemotherapy-induced oral mucositis is regarded as a painful and discomforting chemotherapy complication , affecting patient’s quality of life and endurance to continue the treatment. Hence, treatment of mucositis is of great significance. The present study was conducted to evaluate the effect of Baremoom mouthwash in treatment of chemotherapy-induced mucositis . Methods: This interventional double-blinded randomized clinical trial study was performed on 40 adult patients under chemotherapy in blood and oncology department of Shahid Sadouqhi hospital. The total of 40 patients were randomly divided into two groups: an experimental baremoom group and a control placebo group each containing 20 subjects. Baremoom mouthwash (30% extract, Soren Tektoos, Mashhad) and placebo mouthwash ( Sterile water with allowable additives ,Soren Tektoos, Mashhad ) with same apparent properties were given to the patients (3 times a day) for 7 days after mucositis detection. The patients were evaluated in regard with mucositis grade (0-4 WHO) and wounds extension on 1th , 3th and 7th days after the study begining. In order to statistically analyze the collected data, Freidman, Mann–Whitney, and wilcoxon W tests were applied utilizing SPSS software (ver, 17). Results: On 3rd  and 7th  days, mean degree of wound extension and mucositis were demonstrated to be significantly different between the two groups. According to Friedman test, both experimental and control groups revealed a significant difference in regard with wound extension and mucositis grade within the three time periods. Conclusion: The study findings indicated that Baremoom mouthwash was more effective in chemotherapy- induced mucositis than placebo. Hence, this agent can be recommended as an appropriate medicine in order to eliminate mucositis symtoms and decrease oral ulcers