Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in ‘Creating Clinical Guidelines: Our Protocol’ by the British Society for Rheumatology

Long COVID and cardiovascular disease: a prospective cohort study

Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need

Il Polittico della Cervara di Gerard David

Ricostruzione del polittico eseguito da Gerard David nel 1506 per la chiesa di San Gerolamo della Cervara; analisi del contesto culturale, dell'ambito, dei tempo e delle modalit\ue0 della committenza, del quadro familiare, di cultura cittadina, di relazioni internazionali in cui essa avvenne; indagine iconografica e lettura dell'opera. Quaadro complessivo della produzione dell'artista; analisi tecniche sull'opera che hanno portato a risultati definitivi sulla sua articolazione e composizione oriiginari

The Political Consequences of Perceived Threat and Felt Insecurity

We draw on data from a national RDD telephone sample of 1549 adult Americans conducted between October 15, 2001 and March 2, 2002 to explore the impact of a need for security on support for national security policies in the aftermath of the 911 terrorist attacks. In past research, an external threat has been assumed to have uniform impact on an affected population, a claim that has met with growing research scrutiny. We advance research on threat through an examination of the political effects of individual differences in one’s ability to feel secure in the aftermath of terrorism, exploring the interaction between perceived threat and felt security. Most Americans reported a sense of security after the 911 attacks. But a sense of insecurity among a minority of Americans coupled with a perceived threat of future terrorism increased support for both domestic and international security policy-- the curtailment of domestic civil liberties, tougher visa checks, and support for the war in Afghanistan. Our findings underscore the diverse ways in which individuals react politically to a common external threat. We draw on attachment (Bowlby 1982/1969) and terror management theory (Pyzszcynski et al 2002) to understand the origins of individual differences in felt security