4 research outputs found
The sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level
Hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome.
We hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently
of baseline fibrinogen concentration. We included 266 patients with first-ever ischemic stroke
in whom plasma fibrinogen level was measured on days 1, 7, and 14. The sustained fibrinogen's
increase was defined as the persistent elevation of fibrinogen's concentration on days 7 and 14 by at least
20 % compared to the level on day 1. The functional outcome on day 30 was assessed using modified
Rankin Scale (mRS). Favorable outcome was defined as mRS 0-1. The sustained increase of fibrinogen
was found in 17 % of patients. On multivariate logistic regression analysis adjusted for age, NIHSS
score, baseline fibrinogen >2.66 mmol/L, presence of infection, and hyperglycemia, the sustained fibrinogen's
level was associated with reduced chance of favorable outcome (OR: 0.17, 95 % CI: 0.06-0.48, P<0.01)
Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke
In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1 % men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 months. Hyperfibrinogenemia was found in 25.0 % of patients. On multivariate logistic regression analysis, after adjustment for age, stroke severity, atrial fibrillation, smoking, white blood cell count, fever, in-hospital pneumonia and hyperglycemia, hyperfibrinogenemia was associated with increased case fatality (HR 1.71, 95 % CI 1.29–2.26, P < 0.01). Hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients