The Rules of Forensic Medicine Examination in Diagnosis of Electrical injury in Childhood

Background: History taking is a duty that must get out in different situation as child's parents or in adults by themselves, to able provide the best helps in minimum time. Certainly, the information come out from history have significant effects on management plans. Case Presentation: A 16 months baby that transfers to ER department with complete cardiorespiratory arrest and after response to resuscitation the medical management was done for him. As history taking, he found unconsciousness near dress pan with wet dressing in bathroom. In physical exam the little impact traumatism on his/her head and face was detected. In blood and urine samples, there were not significant findings for toxicological screening. The physician requested for forensic specialist consultation for ruling out any child abuse doubt. The future examination was done by forensic team and they found the hyperkeratotic nodules on palmar surface of first phalange of right index finger due to electrocution. Conclusion: The history taking and following physical exam have greatest significant moment and the detailed and exact physical examination include whole parts of body, especially in children who couldn't present and complain about their problems completely

Demographic Characteristics of Pediatric Burn in Shahid Motahhari Hospital from 2007-2011

Background: Severe burn is one of the major causes of morbidity and mortality in children and adolescents and is third most common cause of death among this age group. The aim of this study was to evaluate demographic characteristics of pediatric burn over a period of 5 years and the relationship between cause mortality in patients with burns. Method: In this cross sectional study, documents of children under 15 years, in Shahid Motahari hospital between 2007 and 2011 was evaluated. Variables such as age, sex, stay duration in hospital, burn cause, severity, accident cause burns and outcome of patients finally entered in SPSS v.16 and were analyzed. Results: In this study, 416 patients (34/8%) were female and 780 (65/2%) were male. Factors for burns in children include boiling water in 674 cases (56/4%), flame in 190 patients (15/9%), burns with flammable materials in 131 cases (11%), burns with a hot meal for 113 people (9/4%) and other hot bodies in 30 patients (2/5) and steam burns in 3 (0/3%). Increasing in burned body surface was significantly associated with mortality (P value= < 0.001). Burn severity in children who died was more than other children (P value= < 0.001). Also burn etiology was significantly different in patients who died and patients were discharged (P Value= 0.003). Conclusion: Based of the results of this study, burn in boys was more than girls and was common inpatients under 2 years of age. Thermal burns were the most common type of burns in children (95/4%) and hot water were also the most important cause in thermal burns in children (56/4%).Burn extent in the majority of children (75%), was less than 30% of the body surface and burns between 50 to 100% occurred in 6/3% of cases. Average stay duration in the hospital was 12/8 days and mortality rate was 7/2%. Area and depth of the burn injury were the most important determinants of mortality

Characteristics of absconders from a general health service, Rasoul Akram Hospital in 2013

Introduction Absconding is an important health and security concern because of its adverse effect on patients, care providers, and the community. Studies are limited. Aim This study aimed to describe the characteristics of absconding events in Tehran. Material and methods In this analytical cross-sectional study, 334 absconders from 34 192 patients who were admitted to the Rasoul Akram Hospital in 2013 and escaped from the hospital were recruited. These patients were evaluated based on variables that included age, sex, marital status, hospitalization duration, smoking, alcohol use, addiction, psychiatric disorders or underlying disease, type of insurance, cause of hospitalization, time of scape, and cost of treatment. Results and discussion The study group consisted of 260 (77.8) males and 74 (22.2) females, with a mean age of 37.4 (SD = 17.1). Mean duration of hospitalization was 99 h (SD = 14.8). A total of 70 (21) patients were smokers, 14 (4.2) consumed alcohol, and 65 (19.5) were drug addicts. Psychiatric disorders were observed in 18 (5.4) patients, and underlying diseases were detected in 87 (26). Higher rates of escape were observed in single men (N = 162; 62.30) as well as married women (N = 52; 70.27). The most common time of escape was 12:00 PM. The highest number of escapes was observed in the month of July. Conclusions The present study identified single males, younger patients, psychiatric disease, underlying illness, and addiction as common features of escapees. Particular attention in observing, improvement in observation methods, and staff focusing on engagement could be helpful in decreasing the number of absconding events. © 2015 Warmi�sko-Mazurska Izba Lekarska w Olsztynie. Published by Elsevier Sp. z o.o. All rights reserved

The Relationship between Environmental, Cultural and Chronological Factors with the Frequency, Cause and Type of Burn Injuries Admitted to the Trauma and Burn Center Motahari Hospital, during the Years 2007to 2011

Background:One of the most important health associated problem are events, which burns considered the most common of them. To prevent burn and reduce the complication and mortality rate, accurate information of epidemiology of burn is essential for planning properly.This study was conducted to determine the relationship between environmental and cultural factors and the type, cause and extent of burn injuries admitted to the trauma and burn center of Motahari hospital during 1386 to 1390.Methods: In this routine data base study, we recruited all burned patients whichreferred to trauma andburncenter of ShahidMotahari hospital between 2007 and 2011. Mainvariables includingeconomic conditions, season ofoccurrenceof the accident,the accident tocurriedonspecial occasions, yearof accident, accidentstatuson holidays, type of injury, cause of injury, injuryseverity, burnarea, anddemographic variables such asage and gender were entered in checklist from patient’s documents.Collected data were entered into softwareSPSS version 11 and were analyzed.Results:5511 patients were admitted to Motahari hospital during the April of 1386 to the end of 1390, from which 1448 (26.3%) cases were female and 4063 (73.7%) male. The mean age of subjects was 28.47 (SD=1.88).There was significant difference between different gender and etiology, so that men were burned more by oil, gasoline and diesel fuel rather than women.There was significant difference about the number of burned cases by the flame at different seasons of the year. Average number of people burned by gas cylinders,electricity,caraccident,bitumen was significantly different in different seasons.Conclusion:There were significant differences about burn injuries due to the gas cylinders,bitumen,electricity and car accidents in different seasons and months.To inform burn centers, principalship of these data increases their ability to manage populated and harmful days. According to the higher rate of explosive burn injury in the last month of the year producing harmless explosive materials can be so effective to support patients lives

Characteristics of traumatic brain injury among accident and falling down cases

Motor vehicle and falling down are responsible for the most number of traumatic injuries. This study aimed to compare the characteristics of traumatic brain injury among accident and falling down cases. In this analytical cross- sectional study, data were collected from the records of cadavers who died due to accident or falling down and referred to Kahrizak dissection hall, Tehran forensic medicine organization during 2013. A total of 237 subjects (183 (77.2) accident and 54 (22.8) falling down) with a mean age of 35.62 (SD=15.75) were evaluated. A number of 213 (89.9) were male. From accident group, scalp injury was seen in 146 (79.8), scalp abrasion in 122 (66.7), scalp laceration in 104 (56.8), sub skull bruising in 176 (96.3), skull fracture in 119 (65), hemorrhage in 166 (90.7), Subdural hemorrhage (SDH) in 155 (84.7), Subarachnoid hemorrhage (SAH) in 161 (88), Epidural hemorrhage (EDH) in 41 (22.4), contusion in 140 (76.5), and skull base fracture in 140 (76.5) of cases. In falling down group scalp injury was seen in 42 (77.8) cadavers, scalp abrasion in 38 (70.4), scalp laceration in 30 (55.6), sub skull bruising in 49 (90.7), skull fracture in 39 (72.2), Hemorrhage in 49 (90.7), SDH in 43 (79.6), SAH in 47 (87), EDH in 10 (18.5), contusion in 33 (61.1), and skull base fracture in 39 (72.2) of cases. There was no significant difference between these two groups (P Value> 0.05). Accident and falling down had no difference in terms of any injury or hemorrhage. © 2015 Tehran University of Medical Sciences. All rights reserved

Electrical Burn Patients According to Electrical Voltage in Shahid Motahari Burn Center

Background: Electrical injuries are rarely happened but it makes more harmful lesions comparing to other thermal injuries. The aim of this study was to report electrical burned patients according to electrical voltage in Shahid Motahari Burn Center.Methods: This Routine data base study was performed on patients with electrical burns which were admitted to Shahid Motahari Burn Center from April 2010 to March 2012. Demographic and clinical data had gathered from medical records. Association between voltage and morbidity or mortality was evaluated used SPSS v. 16.Results: Mean total body surface area of 287 patients (283 (98.60%) male and 4 (1.4%) female) with mean age of 30±0.7 years was 13.56±0.76% (range 1-100). There were 203 patients (70.7%) with low and 84 patients (29.31%) with high voltage injury. There was significant association between voltage and place of injury (p=0.001).Conclusion: High voltage injuries constitute large number of electrical injuries which more of these injuries occurred outdoor and in workplace and need more hospitalization. High voltage injuries are related with more amputation, so people and authorities should pay more attention to such injuries

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

\ua9 2024 The Authors. Published by American Chemical Society.The deposition of thin films plays a crucial role in surface engineering, tailoring structural modifications, and functionalization across diverse applications. Layer-by-layer self-assembly, a prominent thin-film deposition method, has witnessed substantial growth since its mid-20th-century inception, driven by the discovery of eligible materials and innovative assembly technologies. Of these materials, micro- and nanoscopic substrates have received far less interest than their macroscopic counterparts; however, this is changing. The catalogue of eligible materials, including nanoparticles, quantum dots, polymers, proteins, cells and liposomes, along with some well-established layer-by-layer technologies, have combined to unlock impactful applications in biomedicine, as well as other areas like food fortification, and water remediation. To access these fields, several well-established technologies have been used, including tangential flow filtration, fluidized bed, atomization, electrophoretic assembly, and dielectrophoresis. Despite the invention of these technologies, the field of particle layer-by-layer still requires further technological development to achieve a high-yield, automatable, and industrially ready process, a requirement for the diverse, reactionary field of biomedicine and high-throughput pharmaceutical industry. This review provides a background on layer-by-layer, focusing on how its constituent building blocks and bonding mechanisms enable unmatched versatility. The discussion then extends to established and recent technologies employed for coating micro- and nanoscopic matter, evaluating their drawbacks and advantages, and highlighting promising areas in microfluidic approaches, where one distinctly auspicious technology emerges, acoustofluidics. The review also explores the potential and demonstrated application of acoustofluidics in layer-by-layer technology, as well as analyzing existing acoustofluidic technologies beyond LbL coating in areas such as cell trapping, cell sorting, and multidimensional particle manipulation. Finally, the review concludes with future perspectives on layer-by-layer nanoparticle coating and the potential impact of integrating acoustofluidic methods

CRYSTALP2: sequence-based protein crystallization propensity prediction

<p>Abstract</p> <p>Background</p> <p>Current protocols yield crystals for <30% of known proteins, indicating that automatically identifying crystallizable proteins may improve high-throughput structural genomics efforts. We introduce CRYSTALP2, a kernel-based method that predicts the propensity of a given protein sequence to produce diffraction-quality crystals. This method utilizes the composition and collocation of amino acids, isoelectric point, and hydrophobicity, as estimated from the primary sequence, to generate predictions. CRYSTALP2 extends its predecessor, CRYSTALP, by enabling predictions for sequences of unrestricted size and provides improved prediction quality.</p> <p>Results</p> <p>A significant majority of the collocations used by CRYSTALP2 include residues with high conformational entropy, or low entropy and high potential to mediate crystal contacts; notably, such residues are utilized by surface entropy reduction methods. We show that the collocations provide complementary information to the hydrophobicity and isoelectric point. Tests on four datasets show that CRYSTALP2 outperforms several existing sequence-based predictors (CRYSTALP, OB-score, and SECRET). CRYSTALP2's accuracy, MCC, and AROC range between 69.3 and 77.5%, 0.39 and 0.55, and 0.72 and 0.79, respectively. Our predictions are similar in quality and are complementary to the predictions of the most recent ParCrys and XtalPred methods. Our results also suggest that, as work in protein crystallization continues (thereby enlarging the population of proteins with known crystallization propensities), the prediction quality of the CRYSTALP2 method should increase. The prediction model and the datasets used in this contribution can be downloaded from <url>http://biomine.ece.ualberta.ca/CRYSTALP2/CRYSTALP2.html</url>.</p> <p>Conclusion</p> <p>CRYSTALP2 provides relatively accurate crystallization propensity predictions for a given protein chain that either outperform or complement the existing approaches. The proposed method can be used to support current efforts towards improving the success rate in obtaining diffraction-quality crystals.</p

Investigating the relationship between low serum cholesterol and suicide in attempters with depression

Background & Objective: It has been postulated that depressed individuals with low total cholesterol levels may be more likely to die prematurely from suicide. This study aimed to examine the association between low serum cholesterol and suicide in depressed attempters. Materials & Methods: In this cross-sectional study, 180 suicide attempters, who met the inclusion criteria and were willing to participate in the study, were recruited in 2017. The data was collected using a demographic questionnaire and the Beck Depression Inventory-Second Edition (BDI-II). The blood cholesterol level was measured via an auto-analyzer. Results: The mean age was 26.39±10.75 years. The average cholesterol level in the moderate, severe, and serious depression groups was 151.30±35.23, 145.89±36.32, and 145.15±33.33, respectively. The mean age was higher in the group with a higher depression level, though the difference was not significant (P=0.06). The percentage of suicide attempts in single individuals was significantly higher (P=0.02). The mean cholesterol level in the group with the highest level of depression was the lowest, but the difference was insignificant (r=-.01, P=0.85). Only in females, the level of blood cholesterol showed a nearly significant difference between groups with different severities of depression (P=0.05). Cholesterol had a significant correlation with suicide frequency (P=0.008, r=0.28). Conclusion: Our results revealed no significant association between low serum cholesterol and suicide in attempters with depression; but low total serum cholesterol may be associated with depression and suicide in depressed subjects. Yet, more studies are required for verification of this causality. © 2020, Journal of Advances in Medical and Biomedical Research. All rights reserved

Prevalence of isolated hepatitis B core antibody among injection drug users in Central Province of Iran

Numeración errónea en el original