5 research outputs found
CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214
- Author
- A Bensussan
- Adrienne Werth
- AF Huang
- Alain H. Rook
- AM Havens
- Andrea B. Troxel
- B Agrawal
- Bernice M. Benoit
- BO Dulmage
- Brian S. Kim
- BS Kim
- Christopher Miller
- Daniel W. McVicar
- E Ballabio
- E Begue
- E Coustan-Smith
- E Guenova
- E Guenova
- E Penna
- E Poszepczynska-Guigne
- E Scala
- EA Olsen
- EJ Kim
- F Leccia
- G Yin
- Geraldine O’Connor
- GF Murphy
- H Moins-Teisserenc
- Hélène Sicard
- IV Litvinov
- J Tang
- JJ Campbell
- JS Chung
- JS Chung
- Junko Takeshita
- K Ferenczi
- L Kari
- Landon K. Oetjen
- LC Showe
- Lisa Zhu
- M Goswami
- M Nebozhyn
- M Sokolowska-Wojdylo
- M Wysocka
- Maria Wysocka
- MG Narducci
- N Yawalkar
- Neha Jariwala
- P Aliahmad
- PT Jindra
- R van Doorn
- S Jain
- S Morimura
- S Nagata
- SE Boonk
- SM Watt
- T Matsui
- Timothy M. Whelan
- WD Merritt
- Y Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/10/2016
- Field of study
Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), is associated with a significantly shorter life expectancy compared to skin-restricted mycosis fungoides. Early diagnosis of SS is, therefore, key to achieving enhanced therapeutic responses. However, the lack of a biomarker(s) highly specific for malignant CD4+ T cells in SS patients has been a serious obstacle in making an early diagnosis. We recently demonstrated the high expression of CD164 on CD4+ T cells from Sézary syndrome patients with a wide range of circulating tumor burdens. To further characterize CD164 as a potential biomarker for malignant CD4+ T cells, CD164+ and CD164-CD4+ T cells isolated from patients with high-circulating tumor burden, B2 stage, and medium/low tumor burden, B1-B0 stage, were assessed for the expression of genes reported to differentiate SS from normal controls, and associated with malignancy and poor prognosis. The expression of Sézary signature genes: T plastin, GATA-3, along with FCRL3, Tox, and miR-214, was significantly higher, whereas STAT-4 was lower, in CD164+ compared with CD164-CD4+ T cells. While Tox was highly expressed in both B2 and B1-B0 patients, the expression of Sézary signature genes, FCRL3, and miR-214 was associated predominantly with advanced B2 disease. High expression of CD164 mRNA and protein was also detected in skin from CTCL patients. CD164 was co-expressed with KIR3DL2 on circulating CD4+ T cells from high tumor burden SS patients, further providing strong support for CD164 as a disease relevant surface biomarker
From RNA to Loren Williams and Beyond: An RNA perspective of cations involvement in the evolution of life
- Publication venue
- Carleton Digital Commons
- Publication date
- 01/01/2013
- Field of study
The development of the ribosome facilitated the transition from an RNA world to our modern biological systems. Magnesium ions played a crucial role in the early stages of ribosomal development due to their ability to facilitate folded 3D RNA structures that led to novel RNA functions. These ions are still present in modern day systems and play a key role in modern biology
Health Equity in Housing: Evidence and Evidence Gaps
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- Affordability
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- Publication date
- 01/01/2019
- Field of study
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
- Ameijenda Federico
- Amer Hamzi
- Amos Meggan
- Anderson Hunter J.
- Andrew Carter
- Andringa Jesse C
- Angwin Abigail
- Aradhya Arvind J.
- Aramians Andrew
- Arango Camila Villamil
- Archibald Jack. W.
- Arias-Robles Brian A.
- Aryan Maryam
- Ash Kevin
- Astalos Justin
- Atchley-Rivers N. S.
- Augenstein Dakota N.
- Austin Bryce W.
- Avula Abhinav
- Aycock Matthew C.
- Baflah Abdulrahman A.
- Balaji Sahana
- Balajonda Brian
- Balcer Leo M
- Baldwin James O.
- Banda David J
- Bard Titus
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- Barnes Grant M.
- Barnhart Logan D. W.
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- Bastias Catalina S
- Bat-Ulzii Batchimeg
- Batra Jasleen
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- Beach Simone
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- Hayrynen Griffin A.
- Heintz Danielle A.
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- Highhouse Nigel
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- Hintsa Evan
- Hirschmann Anna E.
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- von Peccoz Charles B. Beck
- Von Reich Ferin J.
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- Wallace Steven P.
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- Wang Hongda
- Wang Jiawei
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- Watson James Adam
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- Weigand Anthony A
- Weiner Amanda M.
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- Wheeler Nicola H.
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- Wickenden Evan
- Wilcove Isaac
- Wilkinson Blake C.
- Willard John S.
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- Wilson Evan M.
- Wilson John
- Wilson Orion K.
- Wilson Timothy R.
- Witkoff Briahn
- Wolfe Aubrey M.
- Wolle Jackson R.
- Wood Travis M.
- Woodard Aiden L.
- Woodraska Donald L.
- Wootten Katelynn
- Wu Mengyu
- Xiao Catherine
- Yang Jianing
- Yang Zhanchao
- Yegovtsev Nikolay
- Young Isabel
- Young Trenton J.
- Youngblood Allison A.
- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
- Zhou Chongrui
- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7
Quellen- und Literaturverzeichnis
- Author
- Albisetti James
- Albisetti Peter Lundgreen
- Alings Reinhard
- Alter Peter
- Anderson Benedict
- Andresen Sabine
- Ankum
- Appelt Erna
- Asche Susanne
- Ascheid Antje
- Aschmann Birgit
- Assmann Aleida
- Assmann Jan
- Assmann Jan
- Assmann Jan
- Baer Hester
- Barth Boris
- Barth Dieter
- Barthes Roland
- Baumgartner Antialkoholbewegung
- Becher Ursula
- Becker Eva D
- Becker Frank
- Belach Helga
- Belgum Kirsten
- Berding Helmut
- Berg Christa
- Berg Christa
- Bergen Doris L
- Berghahn Volker R
- Berghoff Peter
- Beßlich Barbara
- Blamberger Günter
- Blom Karen
- Bock Gisela
- Bock Irmgard
- Borst Arno
- Borutta Manuel
- Bottomore Stephen
- Bovenschen Silvia
- Brakensiek Regine
- Brandt
- Brandt Bettina
- Braun Brigitte
- Braun Brigitte
- Braungart Wolfgang
- Brinker-Gabler Karola
- Brokoph-Mauch G.
- Bruch
- Brunn Gerhard
- Bruns Karin
- Bruns Karin
- Bruyn
- Bruyn
- Budde
- Budke Jutta Schulze
- Busch Rolf
- Buschmann Nikolaus
- Butler Judith
- Butzer Günter
- Börsch-Supan Helmut
- Bösch Frank
- Bösch Frank
- Bösch Manuel Borutta
- Bösch Norbert Frei
- Carl Horst
- Carter Erica
- Carter Erica
- Chartier Roger
- Chartier Roger
- Confino Alon
- Conze Vanessa
- Cornejo Paloma
- Crivellari
- Crivellari Marcus Sandl
- Curry Ramona
- Curtis Scott
- Custen George F
- Cöln
- Cöln
- Daniel Hoftheater
- Degener Theresia
- Demandt Luisenkult
- Deutsch Karl W
- Dietze Carola
- Drewes Patricia
- Duchhardt Heinz
- Düding Peter
- Dülffer Karl Holl
- Echternkamp Jörg
- Eckhardt Katharina Hoffmann
- Edensor Tim
- Eggert Hartmut
- Ehrich Karin
- Elias Norbert
- Elisabethschule
- Engeler Knut
- Estermann Georg Jäger
- Fehrenbach Heide
- Feuchter-Schawelka Anne
- Flacke Monika
- FranÅois Hagen Schulze
- Frevert Ehrenmänner
- Frevert Frauen
- Frevert Ute
- Frevert Ute
- Frevert Ute
- Frevert Ute
- Frevert Ute
- Frevert Wolfgang Braungart
- Frey Tugendspiele
- Frieden
- Friederich Gerd
- Fritz Eberhard
- Förster Birte
- Förster Birte
- Förster Birte
- Führ Christoph
- Führ Christoph
- Führer
- Führer Karl
- Gall Lothar
- Geisthövel Alexa
- Geisthövel Alexa
- Geisthövel Alexa
- Geisthövel Alexa
- Genette Paratexte
- Gernert Dörte
- Gernert Dörte
- Geulen Christoph
- Gille Heike
- Giloi Eva
- Giloi Eva
- Glasenapp
- Graf
- Graf Friedrich Wilhelm
- Graf Rüdiger
- Graf Susanne Pellatz
- Gramley Hedda
- Grazia
- Green Fatherlands
- Greven-Aschoff Barbara
- Groot
- Gunning Tom
- Gymnasiums zu Köln
- Günther-Arndt Hilke
- Habermas Rebekka
- Habitzel Günter Mühlberger
- Hagemann Karen
- Hammer Karl
- Hammer Karl
- Hanisch Manfred
- Hannover
- Hardach-Pinke Irene
- Hardtwig Wolfgang
- Harvey Elizabeth
- Hasche Christa
- Haupt Charlotte Tacke
- Haupt Dieter Langewiesche
- Hausen Karin
- Heinsohn Kirsten
- Heinsohn Kirsten
- Heinsohn Kristen
- Herminghouse Magda Mueller
- Herminghouse Magda Mueller
- Hettling Paul Nolte
- Heyl Bettina
- Hick Ulrike
- Hickethier Knut
- Hickethier Knut
- Hickethier Knut
- Hildaschule
- Hinz Renate
- Hobsbawm Eric
- Hobsbawm Eric
- Hof Renate
- Hoffmann Stefan-Ludwig
- Holtz Klaus
- Homans Adrienne Munich
- Honegger Claudia
- Horan Geraldine
- Huerkamp Bildungsbürgerinnen
- Huerkamp Cornelia
- Höhere Mädchenschule Bruchsal
- Höhere Mädchenschule Offenburg
- Hübinger Gangolf
- Hügel
- Hügel Hans-Otto
- Iser Wolfgang
- Jacobsen Klaus Nothnagel
- Jeismann Michael
- Jelavich Peter
- Jesu zu Cöln-Ehrenfeld
- Jonach Michaela
- Jooss Birgit
- Jäger Georg
- Jäger Georg
- Jäger Georg
- Jäger Jörg Schönert
- Jäger Medien
- Jäger Valeska Rudek
- Kahlenberg Friedrich P
- Kahlenberg Friedrich P
- Kalkofen Rupert
- Kantorowicz Ernst
- Kanzog Klaus
- Kaplan Marion
- Katenhusen Ines
- Kenkel Karen J
- Kennedy Katherine D
- Klein Christina
- Kleinau Elke
- Klemm Beate
- Klinger Cornelia
- Klinger Cornelia
- Knoch Daniel Morat
- Koch Gertrud
- Koch Gertrud
- Koch Lars
- Kohlrausch Martin
- Kolb Eberhard
- Koller Wolfgang
- Koonz Claudia
- Korte Helmut
- Korte Sylvia Paletschek
- Kosch Manfred Nagel
- Koselleck Michael Jeismann
- Kracauer Siegfried
- Kracauer Siegfried
- Kracauer Siegfried
- Kraul Margret
- Kreimeier Klaus
- Kroener Bernhard R
- Krumeich Gerd
- Krumeich Gerd
- Kubon Rupert
- Kuhlemann Frank-Michael
- Kuhlemann Frank-Michael
- Kundrus Birthe
- Kurth-Voigt Lieselotte E
- Kuss Horst
- Köllmann Erich
- Küpper Erika
- Langewiesche Dieter
- Langewiesche Dieter
- Langewiesche Dieter
- Langewiesche Nation
- Langland Elizabeth
- Lausch-Jäger Conny
- Lauterer
- Lenger Friedrich
- Lenger Friedrich
- Lenger Friedrich
- Lenk Sabine
- Lenssen
- Lepp Claudia
- Lepsius Susanne
- Liedtke Max
- Lockenour Jay
- Loiperdinger Martin
- Lundgreen Peter
- Lutzer Kerstin
- Lyceums zu Hannover Hannover
- LØvi-Strauss Claude
- Maase Kaspar
- Maase Kaspar
- Maase Kaspar
- Maase Kaspar
- Martino Alberto
- Matala de Mazza Ethel
- Matt
- Matthiesen Helge
- May Otto
- McClintock Anne
- Mergel Thomas
- Mergel Thomas
- Mergen Simone
- Mertens Eberhard
- Meyer Folkert
- Michel Annett
- Minkmar Nils
- Mirsch Beate
- Mirsch Beate
- Moeller Robert G
- Mohn Mythostheorien
- Mosse George L
- Mänz Nils Warnecke
- Möhring Maren
- Möhrmann Renate
- Mühl-Benninghaus Wolfgang
- Müller Corinna
- Müller Detlev K
- Müller Harro
- Müller Schulbuchzulassung
- Münkler Herfried
- Nipperdey Thomas
- Noll Günther
- Nolte Paul
- Nusser Trivialliteratur
- Paletschek Sylvia
- Paletschek Sylvia Schraut
- Paletschek Sylvia Schraut
- Parr Rolf
- Parr Rolf
- Parr Wulf Wülfing
- Petzold Dominik
- Pierson Ruth
- Pingel Falk
- Planert Ute
- Planert Ute
- Planert Ute
- Puschner
- Pyta Hindenburg
- Rajewsky Irina
- Rasche Uta
- Rausch Helke
- Reagin Nancy R
- Reagin Nancy R
- Rechten
- Reder Dirk Alexander
- Reichle Ingeborg
- Requate Jörg
- Riederer Günter
- Riviere Joan
- Rohkrämer Thomas
- Rohlfes Joachim
- Rother Marc Ferro
- Rother Rainer
- Rother Rainer
- Ruchatz Jens
- Ruhrberg Christine
- Röhl
- Röhl
- Saalfeld Dietrich
- Samuel Raphael
- Sarasin Philipp
- Sauer German Werth
- Sauer Michael
- Schallenberger Horst
- Scheck Raffael
- Scheck Raffael
- Scheidgen Irina
- Schellack Fritz
- Schenda Rudolf
- Schenk
- Scheuer Biographie
- Scheuer Biographie
- Scheuer Helmut
- Schildt Axel
- Schildt Axel
- Schildt Axel
- Schildt Axel
- Schildt Nachkriegszeit
- Schilling RenØ
- Schirmer Dietmar
- Schirmer Dietmar
- Schivelbusch Wolfgang
- Schlie Ulrich
- Schlüpmann Heide
- Schlüpmann Heide
- Schlüpmann Heide
- Schmid Pia
- Schmoll Friedemann
- Schneider Ute
- Schneider Ute
- Scholtz Harald
- Schonig Reformpädagogik
- Schorn-Schütte Luise
- Schroeder Ulrich
- Schulte Regina
- Schulz Andreas
- Schulze Versailles
- Schwengelbeck Matthias
- Schwerdt Landerziehungsheimbewegung
- Schöberl Joachim
- Schöck-Quinteros Christiane Streubel
- Schönemann Bernd
- Scott Joan W
- Scott Joan W
- Segeberg Harro
- Shevin-Coetzee Marilyn
- Siekmann Birgit
- Siemann Wolfram
- Simon Holger
- Simson
- Smith Anthony D
- Smith Anthony D
- Speitkamp Denkmalsturz
- Speth Rudolf
- Sprengel Peter
- Steinbacher Einleitung
- Stierle Karlheinz
- Storim Mirjam
- Streubel Christiane
- Suter Andreas
- Sykora Katharina
- Szymansky Tanya
- Süchting-Hänger Andrea
- Süchting-Hänger Andrea
- Tacke Charlotte
- Tacke Charlotte
- Tatlock Lynne
- Thamer Hans-Ulrich
- Thimme Annelise
- Trepp Anne-Charlott
- Tullner Matthias
- Turner Viktor
- Twentieth-Century Europe M.
- Tönnesen Cornelia
- Ulbricht Justus H
- Ulbricht Justus H
- Ulbricht Justus H
- Vinken Barbara
- Voelker Judith
- Vogel Jakob
- Wagner Leonie
- Walcoff Jennifer E
- Walkenhorst Peter
- Walzer Anke
- Wehler
- Weisbrod Bernd
- Wenk Silke
- Westenfelder Frank
- Wieber-Scariot Anja
- Wienfort Monika
- Wildt Michael
- Wilharm Irmgard
- Wilkending Gisela
- Wilkending Gisela
- Winkle Ralph
- Winkler Heinrich August
- Winterscheid Friedrich
- Wittmann Reinhard
- Wolfrum Edgar
- Wolfrum Edgar
- Wolfrum Edgar
- Wülfing Karin
- Wülfing Karin
- Wülfing Wulf
- Wülfing Wulf
- Wülfing Wulf
- Zaepernick Gertraud
- Zahlmann Stefan
- Zehm Ursula
- Zettelbauer Heidrun
- Zimmermann
- zu Köln
- Zymek Bernd
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study