On multidimensional inverse scattering under the Stark effect

We study one of multidimensional inverse scattering problems for quantum systems in a constant electric field, by utilization of the Enss-Weder time-dependent method. The main purpose of this paper is to propose some methods of sharpening key estimates in the analysis, which are much simpler than those in the previous works. Our methods give an appropriate class of short-range potentials which can be determined uniquely by scattering operators, that seems natural in terms of direct scattering problems

Augmented sensitivity of an IR-absorption gas sensor employing a metal hole array

We demonstrate the use of plasmonic extraordinary transmission at IR wavelengths for surface-enhanced infrared absorption (SEIRA) spectroscopy in gas sensing. Gas detection was performed through non-dispersive infrared (NDIR) absorption. The sensitivity of SF6 gas detection is increased around similar to 27 times with metal hole array (MHA) microstructures placed on the gas cell mirrors, as compared with non-structured mirrors; an absorption change of 2% per 100 ppm was obtained on a standard commercial pyroelectric detector. Down-sizing of IR-sensors to a sub-1 mm gas cell width, delivering similar to 40 nM (or 1 ppm) of SF6 sensitivity, can be foreseen with a simple source-detector setup. (C) 2013 Optical Society of Americ

Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in which non-cell-autonomous processes have been proposed as its cause. Non-neuronal cells that constitute the environment around motor neurons are known to mediate the pathogenesis of ALS. Perivascular macrophages (PVM) are immune cells that reside between the blood vessels of the central nervous system and the brain parenchyma; PVM are components of the neurovascular unit and regulate the integrity of the blood-spinal cord barrier (BSCB). However, it is not known whether regulation of BSCB function by PVM is involved in the pathogenesis of ALS. Here, we used SOD1G93A mice to investigate whether PVM is involved in the pathogenesis of ALS. Immunostaining revealed that the number of PVM was increased during the disease progression of ALS in the spinal cord. We also found that both anti-inflammatory Lyve1+ PVM and pro-inflammatory MHCII+ PVM subtypes were increased in SOD1G93A mice, and that subtype heterogeneity was shifted toward MHCII+ PVM compared to wild-type (WT) mice. Then we depleted PVM selectively and continuously in SOD1G93A mice by repeated injection of clodronate liposomes into the cerebrospinal fluid and assessed motor neuron number, neurological score, and survival. Results showed that PVM depletion prevented the loss of motoneurons, slowed disease progression, and prolonged survival. Further histological analysis showed that PVM depletion prevents BSCB collapse by ameliorating the reduction of extracellular matrix proteins necessary for the maintenance of barrier function. These results indicate that PVM are involved in the pathogenesis of ALS, as PVM degrades the extracellular matrix and reduces BSCB function, which may affect motor neuron loss and disease progression. Targeting PVM interventions may represent a novel ALS therapeutic strategy

Discovery of a Long-duration Superflare on a Young Solar-type Star EK Draconis with Nearly Similar Time Evolution for H alpha and White-light Emissions

Young solar-type stars are known to show frequent "superflares, " which may severely influence the habitable worlds on young planets via intense radiation and coronal mass ejections. Here we report an optical spectroscopic and photometric observation of a long-duration superflare on the young solar-type star EK Draconis (50-120 Myr age) with the Seimei telescope and Transiting Exoplanet Survey Satellite. The flare energy 2.6 x 10³⁴ erg and white-light flare duration 2.2 hr are much larger than those of the largest solar flares, and this is the largest superflare on a solar-type star ever detected by optical spectroscopy. The H alpha emission profile shows no significant line asymmetry, meaning no signature of a filament eruption, unlike the only previous detection of a superflare on this star. Also, it did not show significant line broadening, indicating that the nonthermal heating at the flare footpoints is not essential or that the footpoints are behind the limb. The time evolution and duration of the H alpha flare are surprisingly almost the same as those of the white-light flare, which is different from general M-dwarf (super-)flares and solar flares. This unexpected time evolution may suggest that different radiation mechanisms than general solar flares are predominant, such as: (1) radiation from (off-limb) flare loops and (2) re-radiation via radiative back-warming, in both of which the cooling timescales of flare loops could determine the timescales of H alpha and white light

Chemical Characterization of a Volatile Dubnium Compound, DbOCl3

The formation and the chemical characterization of single atoms of dubnium (Db, element 105), in the form of its volatile oxychloride, was investigated using the on-line gas phase chromatography technique, in the temperature range 350–600 °C. Under the exactly same chemical conditions, comparative studies with the lighter homologues of Group 5 in the Periodic Table clearly indicate the volatility sequence being NbOCl3 > TaOCl3 ≥ DbOCl3. From the obtained experimental results, thermochemical data for DbOCl3 were derived. The present study delivers reliable experimental information for theoretical calculations on chemical properties of transactinides

Probable detection of an eruptive filament from a superflare on a solar-type star

太陽型星のスーパーフレアから噴出する巨大フィラメントを初検出 --昔の、そして今の惑星環境や文明に与える脅威--. 京都大学プレスリリース. 2021-12-10.Solar flares are often accompanied by filament/prominence eruptions (~10⁴ K and ~10¹⁰⁻¹¹ cm⁻³), sometimes leading to coronal mass ejections that directly affect the Earth’s environment. ‘Superflares’ are found on some active solar-type (G-type main-sequence) stars, but the filament eruption–coronal mass ejection association has not been established. Here we show that our optical spectroscopic observation of the young solar-type star EK Draconis reveals evidence for a stellar filament eruption associated with a superflare. This superflare emitted a radiated energy of 2.0 × 10³³ erg, and a blueshifted hydrogen absorption component with a high velocity of −510 km s⁻¹ was observed shortly afterwards. The temporal changes in the spectra strongly resemble those of solar filament eruptions. Comparing this eruption with solar filament eruptions in terms of the length scale and velocity strongly suggests that a stellar coronal mass ejection occurred. The erupted filament mass of 1.1 × 10¹⁸ g is ten times larger than those of the largest solar coronal mass ejections. The massive filament eruption and an associated coronal mass ejection provide the opportunity to evaluate how they affect the environment of young exoplanets/the young Earth6 and stellar mass/angular momentum evolution

AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells

A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with EGFR-mutated lung cancer. However, some patients show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib stimulated AXL by inhibiting a negative feedback loop. Activated AXL was associated with EGFR and HER3 in maintaining cell survival and inducing the emergence of cells tolerant to osimertinib. AXL inhibition reduced the viability of EGFR-mutated lung cancer cells overexpressing AXL that were exposed to osimertinib. The addition of an AXL inhibitor during either the initial or tolerant phases reduced tumor size and delayed tumor re-growth compared to osimertinib alone. AXL was highly expressed in clinical specimens of EGFR-mutated lung cancers and its high expression was associated with a low response rate to EGFR-TKI. These results indicated pivotal roles for AXL and its inhibition in the intrinsic resistance to osimertinib and the emergence of osimertinib-tolerant cells