Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

The transmission of values in European Malta

SIGLEAvailable from British Library Document Supply Centre- DSC:D172925 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

The Generational Seesaw Mechanism in [SU(6)]3×^{3}\timesZ3_{3}}

In the context of the left-right symmetric gauge group [SU(6)]$^3\times$ Z$_3$ which unifies nongravitational forces with flavors, we analyze the generational seesaw mechanism. At tree level we get m$_{\nu_\tau}\sim$m$_{\nu_\mu}\sim$M$^2_L$/M$_H$, m$_{\nu_e}=0$, where M$_L\sim10^2$ GeVs and M$_H\ge 100$ TeVs is the mass scale at which the horizontal interactions get spontaneously broken. The right handed neutrinos get a Majorana mass M$_R\gg$M$_H$ of the order of the scale where SU(2)$_R$ is broken. An exotic neutral lepton with a mass of the order of M$^2_H$/M$_R$ is predicted. First order radiative corrections will produce m$_{\nu_e}\neq0$ which is at least two orders of magnitude smaller than the other two neutrino masses

SEARCH FOR HEAVY NEUTRINO DECAYS IN THE BEBC BEAM DUMP EXPERIMENT

New limits on lepton mixing parameters are derived from a search for decays of heavy neutrinos in a proton beam dump experiment. The limits |Uøi|2, |Uei|2 < 10-6-10-7 are obtained for neutrino mass eigenstates vi of mass between 0.5 and 1.75 GeV, which can be produced through mixing in charmed D meson decays. This is the first such limit on |Uøi|2 for neutrino masses greater than 0.5 GeV. For the mass eigenstate v3 in particular, we obtain the limits |Uø3|2 < 10-7-10-8, |Ue3|2 < 10-9-10-10 for the mass range 150-190 MeV, assuming the v3 to be produced directly in charmed F meson decays. © 1985