Comparison of Odor Intensity between Nylon and Polyester

The purpose of this study was to compare fabrics made from nylon and polyester fibers in odor intensity following wear against the underarm. Fabrics were sewn into the underarm region of a t-shirt and odor intensity was assessed using a trained sensory panel. Results showed that nylon and polyester fabrics did not tend to differ significantly from one another. This finding was unexpected given nylon is more hydrophilic than polyester and previous research has found an inverse relationship between moisture regain and odor intensity when comparing polyester with fabrics made from natural fibers. The lack of a difference may be due to nylon fabrics being heavier than polyester

Nigella sativa's protective effect in acetaminophen induced liver toxicity in mice

Acetaminophen has contributed to acute liver failure disease in more than half of the USA and Britain but as an analgesic and antipyretic it is very effective. For many decades in Europe, Middle East and Africa, Nigella sativa has been used for various medical purposes, it is part of the botanical family Ranunculaceae of   Gently sloping plants, and is called black cumin seed., Nigella sativa conjugated sterols could be used as precursors to many hydrosoluble steroids for hemisynthesis. The aim of the Study   is to examine the promising hepatoprotective effects of Nigella sativa against Acetaminopheninduce hepatotoxicity in mice in this experiment Forty adult male albino mice, incorporated in the experiment   and Acetaminophenwas used to induce hepatotoxicity in a dose of 1 gm /kg by the oral route. A number of biochemical and histopathological tests have been used to evaluate liver damage and Nigella sativa protective effects. The result showed a significant protective effect of Nigella sativa against acetaminophenhepatotoxic effect as Nigella sativa in this study tended to normalize the serum levels of liver enzymes, and the protective effects observed clearly by the histopathological evaluation confirming that it effectively protected mouse livers against severe damage caused by acetaminophen. Conclusion in our study it shows that Nigella sativa   have a very significant protective effects against acetaminophen induced liver toxicity which is recommended to be fully investigation on human especially to people on risk of acetaminophen liver toxicity  

A DUPLICATE ACTIVE STORAGE INDEXES FOR MULTIPLE CLIENT ENVIRONMENTS

As opposed to the present authenticated structures, for example skip list and Merkle tree, we design a singular authenticated structure known as Homomorphic Authenticated Tree, we present additional information about PoS and dynamic PoS. Whenever a verifier wants to determine the integrity of the file, it at random selects some block indexes from the file, and transmits these to the cloud server. To the very best of our understanding, no existing dynamic PoSs supports this method. We developed a novel tool known as HAT which is an excellent authenticated structure. We suggested the excellent needs in multi-user cloud storage systems and introduced the type of deduplicatable dynamic PoS. Existing dynamic PoSs can't be extended towards the multi-user atmosphere. Because of the problem of structure diversity and tag generation, existing system can't be extended to dynamic PoS. An operating multi-user cloud storage system needs the secure client-side mix-user deduplication technique, which enables a person to skip the uploading process and acquire the possession from the files immediately, when other proprietors of the identical files have submitted these to the cloud server. to lessen the communication cost both in the evidence of storage phase and also the deduplication phase concentrating on the same computation cost. We prove the safety in our construction, and also the theoretical analysis and experimental results reveal that our construction is efficient used. Within this paper, we introduce the idea of deduplicatable dynamic evidence of storage and propose a competent construction known as DeyPoS, to attain dynamic PoS and secure mix-user deduplication, concurrently

Experimental Investigation of Metal-Based Calixarenes as Dispersed Catalyst Precursors for Heavy Oil Hydrocracking

Slurry-phase hydrocracking utilizing metal-containing oil-soluble compounds as precursors of dispersed catalysts is an effective approach for heavy oil upgrading. We propose applying metal-based p-tert-butylcalix[6]arene (TBC[6]s) organic species as dispersed catalyst precursors to enhance catalytic hydrogenation reactions involved in the upgrading of vacuum gas oil (VGO). Co- and Ni-based TBC[6]s were synthesized and characterized by SEM-EDX, ICP, XRD, and FT-IR. The thermogravimetric and calorimetric behaviors of the synthesized complexes, which are key properties of dispersed hydrocracking catalysts, were also explored. The experimental evaluation of the synthesized catalyst precursors show that the synthesized metal-based TBC[6] catalyst precursors improved the catalytic hydrogenation reactions. A co-catalytic system was also investigated by adding a commercial, first-stage hydrocracking supported catalyst in addition to the dispersed catalysts. The naphtha yields increased from 10.7 wt.% for the supported catalyst to 11.7 wt.% and 12 wt.% after adding it along with Ni-TBC[6] and Co-TBC[6], respectively. Mixing the metal-based precursors resulted in elevated yields of liquid products due to the in situ generation of highly active Co–Ni bimetallic dispersed catalysts.This research was funded by Deanship of Research Oversight and Coordination (DROC) at King Fahd University of Petroleum and Minerals (KFUPM), grant number DF181018

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Comparison of Odor Intensity between Nylon and Polyester

The purpose of this study was to compare fabrics made from nylon and polyester fibers in odor intensity following wear against the underarm. Fabrics were sewn into the underarm region of a t-shirt and odor intensity was assessed using a trained sensory panel. Results showed that nylon and polyester fabrics did not tend to differ significantly from one another. This finding was unexpected given nylon is more hydrophilic than polyester and previous research has found an inverse relationship between moisture regain and odor intensity when comparing polyester with fabrics made from natural fibers. The lack of a difference may be due to nylon fabrics being heavier than polyester.</p

Exploring the Factors associated changes in the personal habits of frontline healthcare workers during COVID-19 pandemic

Introduction: The World Health Organization (WHO) announced on 11 March 2020, that the SARS-CoV2 outbreak that started in December 2019 became a pandemic. Reported illnesses have ranged from very mild to severe (from progressive respiratory failure to death). Clinical symptoms caused by the virus include loss of taste and smell, fever, malaise, dry cough, shortness of breath, and respiratory distress. Material &amp; Methods: This prospective cross-sectional observational seroprevalence study is conducted at Tertiary care teaching Hospital. Various groups of participants in the study - Seroprevalence of SARS -CoV-2 IgG in health care professionals at tertiary care teaching medical institutions in RR district, Telangana. A serum bank covering all regions was constituted by collecting residual sera from various diagnostic laboratories in region. Large laboratories were engaged, with high daily throughput covering primary care and all kinds of ambulatory specialist care outside hospital. Result: In our study, total of 53.04% were symptomatic and 46.95% were asymptomatic. Exposed staff were 30% and unexposed staff were 70%. In addition, Travel history were 19.13% and Family history 14.34%. BCG vaccinated were 85.21%. On the other hand, Symptomatic staff mean of over all Antibody titer 11.56+16.36, Antibody titer in vaccinated group 25.30+18.01 and Antibody titer in not vaccinated group 2.95+6.43.Conclusion: The job satisfaction of frontline medical staff by developing specific policies for medical staff in similar public health emergencies. The form of participation, prioritizing the self-fulfillment needs of medical staff with high education levels and strengthening the emergency response and practical operation training of junior staff